Arterial hypertension is a persistent increase in blood pressure. In this condition, the following indicators are observed: 140/90 mm RT. Art. and more.
Specialists claim that arterial hypertension is one of the most common diseases of the cardiovascular system. According to statistics, about 20-30% of the entire adult population is exposed to it. Moreover, with age, the prevalence of this disease increases markedly and often reaches 50-65%.
This condition can occur due to many reasons. Most often, hypertension develops due to psycho-emotional overstrain.
Specialists identify several risk factors for the spread of this disease. These include: age, a sedentary lifestyle, gender, excessive consumption of sodium chloride, a low-calcium diet, alcohol abuse, heredity, smoking, obesity, diabetes mellitus and others.
Lowering high blood pressure should be required. Otherwise, this can lead to disastrous consequences.
Most often, with hypertension, doctors prescribe a drug such as Vero-Amlodipine to their patients.
Instructions for use, reviews, analogues and properties of the drug will be presented below.
Composition, description, packaging, composition
The medicine "Vero-Amlodipine" is available in the form of flat-cylindrical white tablets. The main component of this tool is amlodipine. It is presented in the form of besylate.
Vero-Amlodipine tablets go on sale in contour cells (10 pieces each), which are contained in a cardboard box.
Pharmacological characteristics of the drug
What is a remedy like Vero-Amlodipine? Instructions for use indicate that this drug is able to have a pronounced antihypertensive and antianginal effect. It prevents the entry of Ca ions through membranes into the cells of the myocardium and blood vessels.
This medicine lowers blood pressure due to the ability to dilate blood vessels.
The antianginal effect of the drug is provided by its active substance. Experts say amlodipine is able to not only expand peripheral arterioles, but also help reduce OPSS. However, it does not cause reflex tachycardia.
Due to this effect, the heart muscle begins to consume less energy, as well as significantly reduce myocardial oxygen demand.
It should be noted that with the occurrence of spasms of the coronary arteries, the medication in question contributes to an increase in oxygen delivery to almost all areas of the myocardium.
Kinetic indicators
What kinetic properties are characteristic of Vero-Amlodipine tablets? Instructions for use informs that when taking the medicine inside it is slowly but almost completely absorbed from the digestive tract.
The peak concentration of this agent in the blood is reached within 8-9 hours. Binding to plasma proteins is about 97-98%.
The drug in question undergoes minimal metabolism, forming derivatives with negligible pharmacological activity. This happens when you first pass through the liver.
The average half-life of a drug is 35 hours. With arterial hypertension, this period can increase up to 48 hours, in the elderly - up to 65 hours, and with impaired liver function - up to 60 hours.
This medication is excreted mainly in the form of metabolites through the kidneys (about 58-62%) and through the intestines (about 20-27%).
Indications for taking the medicine
In what cases are Vero-Amlodipine tablets prescribed? Indications for use of this tool are as follows:
- vasospasm or vasoconstriction;
- arterial hypertension (in the form of monotherapy, as well as in conjunction with other drugs);
- stable angina pectoris;
- vasospastic angina pectoris;
- dilated cardiomyopathy (non-ischemic) with 3-4 stages of heart failure (chronic).
We can not say that the drug in question can be prescribed in the form of monotherapy. Also, it is often used in conjunction with antianginal drugs (prescribed for people who are immune to nitrate therapy or beta-blockers).
Contraindications to taking pills
In what cases can not be prescribed medication "Vero-Amlodipine"? The use of this medication is prohibited for arterial hypotension. Also, the drug in question is not prescribed for minor children and in the presence of hypersensitivity to amlodipine or other dihydropyridines.
Medication "Vero-Amlodipine": instructions for use
This medication is intended for oral use only. Its dosage is set by the attending physician, depending on the condition of the patient.
For people with angina pectoris or arterial hypertension, the minimum daily dose is 5 mg. In the future (if absolutely necessary), the indicated amount of the drug is allowed to be increased to 10 mg a day.
In the presence of dilated cardiomyopathy, it is advisable to start therapy with a dosage of 2.5 mg. Later (with normal tolerance to the drug), this dose can be increased to 10 mg.
According to the instructions, exceeding the indicated amount of the drug (10 mg per day) is highly not recommended. This is due to the fact that it is the maximum allowable.
The simultaneous use of the drug "Vero-Amlodipine" with beta-blockers, as well as ACE inhibitors and thiazide diuretics does not require dose adjustment.
Side effects
The medicine "Vero-Amlodipine", reviews of which are always positive, in rare cases can cause (if dosage is not observed):
- gingival hyperplasia, nausea and sharp abdominal pain;
- tachycardia, hyperemia, arrhythmia, palpitations, shortness of breath, peripheral edema, arterial hypotension;
- paresthesia, fatigue, drowsiness, headache, dizziness;
- rash, itching.
It cannot be said that with prolonged use of Vero-Amlodipine tablets, the patient may experience severe pain in the limbs.
Drug overdose
What will happen if the dose of Vero-Amlodipine is significantly exceeded? Instructions for use do not give any information about the symptoms of an overdose. Although experts say that in this case, pronounced adverse reactions are manifested.
Interaction with other drugs
Is it possible to take Vero-Amlodipine tablets with other drugs (what is this drug prescribed for, we described above)?
The antihypertensive effect of this drug is enhanced by its combination with calcium channel blockers. The same result can be expected when taking a medication intended for inhalation anesthesia, as well as orlistat. Moreover, such combinations can provoke a sharp increase in pressure and a hypertensive crisis.
A delay in sodium in the patient’s body and, as a result, a decrease in the antihypertensive effect is observed with amlodimpine with sympathomimetics and estrogens. To enhance these properties, you must simultaneously take "Quinidine" or "Amiodarone."
The occurrence of such signs of neurotoxicity as nausea, tinnitus, vomiting, ataxia, and diarrhea can be caused by the simultaneous administration of Vero-Amlodipine and lithium carbonate.
The combination of the drug in question with indomethacin or other NSAIDs often leads to a decrease in its antihypertensive effect.
Breastfeeding and pregnancy
Is it possible to take Vero-Amlodipine medication, which analogues are listed below, during pregnancy? According to experts, the safety of this medicine during the period of gestation has not been studied. The same goes for breastfeeding. Therefore, to prescribe this drug in such conditions should only be if the risk to the baby is much less than the benefit to the health of the mother.
Special recommendations for taking pills
What should the patient know before taking the drug in question? According to the instructions, this remedy is prescribed with extreme caution in case of stenosis of the aortic orifice and impaired functioning of the kidneys and liver.
Adjustment of the above dose to older people is not required.
Vero-Amlodipine can be used to treat patients with dilated cardiomyopathy (non-ischemic), accompanied by heart failure (chronic).
There are no clinical data on the use of this medicine in pediatric practice.
Duration of the drug, storage and sale conditions
It is desirable to contain this medication in a dry and dark place where there is no access for small children, and where the air temperature does not exceed 26 degrees.
This drug is dispensed in pharmacies without a medical prescription. Its implementation period is two years. After this period, taking pills is prohibited.
Cost and similar
About how much the drug "Vero-Amlodipine", you can find out only in the pharmacy. As a rule, its price depends on the number of tablets in the package and dosage. 10 mg of the drug cost about 57 rubles, and 5 mg - 30 rubles.
As for the analogues, the means under consideration have quite a lot of them. According to experts, antihypertensive properties are inherent in the following medicines: Agen, Akridipin, Adipin, Amlo, Amlodipine Sandoz, Amlodipin, Amlodipin-Teva, Amlodak, Amlovas, Amlodigamma ”,“ Amlodipine Alkaloid ”,“ Amlodil ”,“ Amlodipin Zentiva ”,“ Amlodipin-Agio ”,“ Amlodipine Cardio ”,“ Amlodipine besilat ”,“ Amlokard-Sanovel ”,“ Amlodipharm ”,“ Amlong ”,“ Amlorus ”, Amlotop, Amlonorm, Kalchek, Karmagip, Kardilopin, Korvadil, Norvadin, Cordy Kor, Norvask, Omelar Cardio, Normodipin, Stamlo, "Stamlo M", "C Tamlo M ”,“ Tenox ”.
What is the difference between Amlodipine and Vero-Amlodipine?
It is rather difficult to unequivocally answer the question posed. After all, both of the mentioned drugs contain the same active substance in the same doses.
According to expert reviews, these funds are distinguished only by the fact that they were issued by various pharmaceutical companies. Accordingly, the production technology of Amlodipine and Vero-Amlodipine is different.
It is not possible to talk about the greater effectiveness of this or that remedy, since they have the same effect and are designed to lower high blood pressure.
It should also be noted that these drugs may have different prices.
Consumer reviews and messages from doctors
With age, hypertension covers more and more people. Such a disease is characterized by severe headaches, dizziness, darkening in the eyes, weakness, excessive fatigue and so on. As a rule, all of these symptoms disappear within a few hours after taking the medication in question.
Doctors say that the drug "Vero-Amlodipine" is one of the most effective and fastest drugs. In a short period of time, it normalizes blood pressure, significantly improving the patient's condition.
Among the advantages of this drug, many note its convenient form and method of use. To lower high blood pressure, only one tablet per day is required. At the same time, experts warn that exceeding the doses recommended by them can lead to adverse reactions. Therefore, more than 10 mg of the drug per day should not be taken.
It should also be noted that very many patients are pleased with the low cost of the mentioned tool, its availability and the ability to replace with analogues of other manufacturers.