Why is Pangrol 10000 prescribed? Instructions for use, analogues and indications of the mentioned medication will be presented later. You will also learn about the dosage in which the medication is prescribed for children, what is included in its composition, whether it has side effects and contraindications.
Form, description, composition of the medication
In what form is Pangrol 10000 produced? Instruction, reviews state that this drug is made in the form of opaque gelatin capsules. Their body is orange and the lid is green.
The contents of the capsules are small cylindrical tablets. They have an enteric coating, smooth surface and beige color.
What substances are included in the medication "Pangrol 10000"? The instruction says that the active ingredient in this medicine is pancreatin. Also, the medication includes additional components in the form of magnesium stearate, croscarmellose sodium, hydrogenated castor oil, colloidal anhydrous silicon dioxide and microcellulose.
Features
What is a medicine like Pangrol 10000? The instruction reports that this medication is a digestive and enzymatic agent. It makes up for the deficiency of enzymes that are necessary for the normal functioning of the pancreas. Also, this drug produces proteolytic, amylolytic and lipolytic effects.
Operating principle
What is the mechanism of action of the drug "Pangrol 10000"? The instructions indicate that the pancreatin contained in this medicine is a powder. It is obtained through the processing of animal pancreas (in particular, pigs).
The enzymes contained in it have a beneficial effect on the digestion process. In addition, they accelerate the breakdown of proteins, carbohydrates and fats, help the normal functioning of the pancreas.
Due to the fact that “Pangrol 10000” (instructions for use for children will be discussed later) promotes the digestion of food, it quickly removes all signs of indigestion (for example, if there is shortness of breath, a feeling of heaviness in the abdomen, pain, overflow of the stomach, flatulence, etc.) .
Capsules stimulate the small intestine, pancreas, and stomach to produce enzymes that are directly involved in digestion.
The bile extract, which is part of the medication, enhances the emulsification of fats, acting on the human body in a choleretic way. This substance increases lipase activity, which improves the absorption and digestion of fat-soluble vitamins K, A and E, as well as fats, which enter the stomach with food.
Pharmacokinetics
Is Pangrol 10000 absorbed? The manual states that the capsules are coated with an acid resistant coating. It helps protect the medication from gastric juice. As a result of this, the drug freely enters the small intestine. In it, the capsule shell dissolves quite quickly and releases its contents, that is, mini-tablets.
For the effective effect of the drug in the small intestine, it is necessary to maintain a slightly alkaline pH level (or neutral).
The medication in question is not absorbed in the digestive tract. It is excreted through the intestines.
Indications for use
Why can Pangrol 10000 be used? Instructions for use for children and adults say that this medication is prescribed if necessary for the replacement treatment of exocrine pancreatic disorders. In addition, the drug in question is used for enzyme deficiency caused by one of the following diseases:
- Schwachman-Diamond syndrome;
- cystic fibrosis;
- irritable bowel syndrome;
- narrowing of the pancreatic ducts;
- the presence of gallstones;
- malignant tumor;
- intestinal infections;
- pancreatitis (chronic or acute stages);
- digestive tract disorders.
What other purposes can Pangrol 10000 be assigned to? The instruction for children and adults states that this medication is used as preparation for an x-ray or ultrasound examination of the abdominal cavity. In addition, capsules are taken to restore the normal functioning of the stomach and pancreas after surgery, as well as as part of a comprehensive treatment after radiation therapy for symptoms such as indigestion, gas and diarrhea.
Contraindications
What are the conditions for not taking Pangrol 10000 capsules? Instructions for children, reviews of experts report the following prohibitions:
- acute pancreatitis;
- hypersensitivity;
- exacerbation of pancreatitis.
Method of application for young children
At what dose is Pangrol 10000 prescribed? The instructions for children say that the amount of this drug should be determined only by an experienced pediatrician. As a rule, the dosage of the drug is calculated according to the following scheme: 500-1000 units of lipase per kilogram of the baby’s weight.
The duration of therapy depends on the patient’s health status, type and severity of the disease. If the child cannot take the whole capsule, then its contents are mixed with water or food that there is no need to chew (for example, porridge or fruit puree). The resulting mixture should be consumed immediately. Keep it prohibited.
In the treatment of cystic fibrosis, the volume of the drug also depends on the body weight of the child. The initial dosage for babies up to four years is 1000 units of lipase per kg of weight, and for children over this age - 500 units.
When using the drug in pediatric practice, a strict diet is required to exclude the development of steatorrhea.
Dosage for adults
Capsules "Pangrol 10000" must be taken with food. They are not chewed, but swallowed whole, washed down with water.
The dose of the medicine is determined by the therapist or gastroenterologist (depending on the condition of the patient, the form and severity of the disease). As a rule, adults are prescribed two to four capsules per day. If necessary, the doctor can increase the daily dose of the drug.
Side effects
Unwanted reactions such as diarrhea, nausea, abdominal pain, vomiting, bloating and other digestive disorders can occur in children and adults while taking this drug.
Very rarely, patients are allergic to the drug "Pangrol." Usually it is expressed in the appearance of urticaria, itching or a rash on the skin.
If such effects are detected, it is required to stop taking the medication and consult a doctor.
Overdose cases
There are few reviews of an overdose of Pangrol. As a rule, with an increase in the number of enzymes during the treatment of cystic fibrosis, diseases such as hyperuricosuria and hyperuricemia occur.
Special Advice
Before taking Pangrol capsules, be sure to read the attached instructions. It says that during the treatment of cystic fibrosis, people who have received large doses of the drug may develop fibrosing colonopathy (that is, strictures of the cecum, ileum, or colon).
To avoid changes in the symptoms of the underlying disease, before taking this drug, you must undergo a medical study, which will eliminate the presence of intestinal lesions.
The medicine in question does not affect the patient’s ability to drive vehicles, nor does he reduce the speed of his reaction while working with dangerous mechanisms.
Analogs and cost of the drug
Today, there are a large number of drugs to improve the functioning of the pancreas and stomach. The following drugs are structural analogues of the Pangrol medication: Hermitage, Gastenorm Forte, Pankrelipaza, Creon, Enzistal-P, Mezim, Penzital, Mikrasim, Pancreatin Forte, Mezim Forte, Festal, PanziKam, Panzitrat, Panzinorm, Pancreatin-LekT, Pancreatin, Panzim Forte, Panzinorm Fort.
As for the price, you can buy 20 capsules of this drug for 250-300 rubles.
Reviews of consumers about the drug
Capsules "Pangrol 10000" are very popular among patients. Reviews about this drug are mostly positive. People who regularly take this remedy talk about its quick action and high effectiveness.
“Pangrol” significantly improves the digestion process, thereby eliminating heaviness, pain and a feeling of fullness of the stomach. Also, thanks to this medication, you can get rid of excessive gas formation, nausea, heartburn, and other unpleasant conditions that appear during the intake of fatty and high-calorie foods.
The only disadvantage of this drug is the difficulty in calculating the dosage, especially for young children. Due to the fact that digestive problems are purely individual in nature, only an experienced doctor can choose the right dosage. This fact greatly complicates the independent use of the drug.