Why is a drug like Terfenadine needed? Instructions for use, price, reviews, as well as the therapeutic purpose of this medication are listed below. In addition, this article provides information about the features of the mentioned drug, its analogues and contraindications.
Release form and constituent components of the product
In what form is the medicine "Terfenadine" made? Instructions for use states that this medicine can be purchased in the form of tablets that contain such an active ingredient as terfenadine. In addition, the agent in question is available in the form of a suspension for oral administration, syrup and crystalline powder intended for the preparation of a solution.
Features of the medication
What is Terfenadine? The instruction for use claims that it is an antihistamine. It is able to selectively block peripheral H1-histamine receptors, as well as prevent the expansion of capillaries and increase their permeability, smooth muscle spasms, including bronchoconstriction in people with asthma, the development of erythema, angioedema and itching.
The effect after applying this medicine appears after two hours and reaches its maximum after four. At the same time, it persists for more than half a day.
For allergic rhinitis, this drug eases and reduces the frequency of sneezing, and also reduces itching, rhinorrhea, and lacrimation.
Other properties of the drug
What is remarkable about a drug like Terfenadine? Instructions for use (the price of the medicine is indicated below) claims that this drug has a moderate anticholinergic effect, and also blocks the channels (potassium) of cardiomyocytes and weakens the severity of bronchospasm.
A significant increase in terfenadine in the blood may be accompanied by an increase in QT time and the development of serious heart complications.
Kinetic ability
How quickly is Terfenadine absorbed? Instructions for use states that this agent is absorbed from the digestive tract very quickly. It is determined in blood plasma after 30 minutes.
This medication binds to plasma proteins by 97%. It is actively metabolized in the liver with the formation of two metabolites.
The medicine "Terfenadine" is equally effective for all groups of patients, regardless of their age.
Indications
In what cases is the medicine "Terfenadine" prescribed? Instructions for use report that this remedy is highly effective for seasonal allergic rhinitis, allergic conjunctivitis, chronic idiopathic urticaria, atopic eczema, contact dermatitis, rash and itching caused by liver damage. Also, this medication is prescribed for angioedema, allergic reactions caused by drugs, insect bites and food, bronchial asthma and colds (only as part of combination therapy).
In addition, this drug is often used to prevent allergies, which manifests itself with the introduction of radiopaque agents.
Prohibitions for appointment
The medicine "Terfenadine" is contraindicated for use in case of hypersensitivity, hypokalemia, hypomagnesemia, prolongation of the QT interval on the ECG, severe violations in the liver and in children (for the tablet form - up to six years, and for suspension - up to three years).
The drug "Terfenadine": instructions for use
Analogues of this medication are listed below.
The mentioned remedy is prescribed inside adults and children from twelve years old, 60 mg twice a day or 120 mg once a day. The greatest amount of the drug taken in 24 hours is 480 mg.
For children 6-12 years old, this medicine is prescribed 30 mg twice a day, and for children 3-5 years old they are given a suspension in a dosage of 15 mg twice a day.
Side effects
During treatment with Terfenadine, patients may experience adverse reactions such as:
- weakness, palpitations, headache, lengthening of the QT interval, dizziness;
- ventricular tachyarrhythmia, sleep disturbance, extrasystole, drowsiness, ventricular fibrillation, nervousness;
- depression, cardiac arrest, fever, hypotension, impaired hematopoiesis, fainting;
- thrombocytopenia, convulsions, dry oral mucosa, paresthesia, increased appetite, visual impairment, dyspeptic symptoms;
- bronchospasm, nausea, dry mucous membranes of the nose and throat, vomiting, coughing, abdominal discomfort, sore throat;
- change in stool frequency, nosebleeds, cholestasis, frequent urination, jaundice, dysmenorrhea, hepatitis;
- tremor, rash, urticaria, eczema, photosensitivity, thinning hair, angioedema, alopecia;
- galactorrhea, anaphylaxis, sweating.
Analogs, price, reviews
Analogs of the medication in question are "Trexil" and "Bronal." The price of this medicine is about 190-215 rubles per 10 tablets.
Reviews on the drug "Terfenadine" are mostly positive. Patients claim that this remedy copes well with various allergic reactions. The disadvantages of this drug include the presence of side effects.