Recently, doctors often prescribe Algezir Ultra to patients. The instruction for this tool is quite informative and describes the features of its use for various categories of patients, but at the same time it provides far from complete information regarding how this tool affects the body.
Pharmacology
The composition of the drug is NSAIDs, which is a derivative of naphthylpropionic acid. In the process of taking this drug is anti-inflammatory, antipyretic, as well as analgesic effect, as often indicated by reviews of Algesir Ultra. Instructions for the tool also indicate these nuances.
The mechanism of action of the drug is directly related to the inhibition of the specialized enzyme COX, which allows to inhibit the synthesis of prostaglandids from arachidonic acid as efficiently as possible. Also, this tool provides suppression of platelet aggregation.
Particular attention should be paid to the fact that in the process of taking the drug, pain is reduced, including joint pain both in motion and at rest. In the process of taking, the swelling of the joints, morning stiffness decreases, the range of movements increases, which is noted by almost every person who left a review about the Algezir Ultra. The instruction also contains such information, while it also notes that an anti-inflammatory effect can be achieved by the end of the first week of active treatment.
Pharmacokinetics
Subsequently, taking this drug inside naproxen begins to be absorbed quite quickly from the digestive tract. The indicator of C max in plasma begins to be observed for 1-4 hours after administration. It is worth noting that the simultaneous use of this medication with food can somewhat slow down the rate of absorption, but it does not reduce the overall degree of absorption. Naproxen has a fairly good absorption in the case of rectal administration, but in this case there is a much slower absorption, when compared with ingestion.
In therapeutic concentrations, this element binds to plasma proteins almost 100%. The concentration of naproxen in plasma increases proportionally during the use of doses up to 500 mg, while at higher doses there is an increase in clearance, which is due to the full saturation of plasma proteins.
Naproxen diffuses into the synovial fluid.
T 1/2 is approximately 13 hours. About 95% of the total amount of this dose is ultimately excreted in the urine in an unchanged state, 6-O-desmethylnaproxen and its various conjugates. Everything else in the near future after administration is excreted in the feces.
Dosage
It is worth noting that it is recommended that the individual dosage is set in accordance with the severity of the disease in the patient. For Algezir Ultra, the instruction says that adults are recommended to take it in doses of 0.5-1 g per day in two doses, while the daily dose for normal maintenance treatment should be about 500 mg.
The maximum possible daily dose is 1.75 g.
Dosage for children
If treatment is carried out in patients aged 1 to 5 years, then in this case they should use 2.5-5 mg per kg per day for 1-3 doses daily, while the maximum possible course of treatment in this case can be 14 days. In the treatment of juvenile arthritis in children over 5 years of age, the daily dose is fixed at 10 mg per kg.
Drug Interactions Algezir Ultra
The instructions for use also say that if it is used simultaneously with antacids, which include aluminum and magnesium, as well as sodium bicarbonate, then this negatively affects the absorption of naproxen, which is quite important in the treatment process.
If the tool is used together with indirect anticoagulants, then there may be slight amplification of the action of these drugs, which was noted in the process of conducting specialized clinical studies.
Also, in the process of conducting research, the effect of the simultaneous use of the drug with amoxicillin was studied, as a result of which, in certain situations, nephrotic syndrome began to develop . If Algezir Ultra was used with acetylsalicylic acid, in some cases the total concentration of naproxen in the blood plasma decreased.
Additional interaction features
Among other things, it is worth noting a few more situations that are indicated by the instructions for use for the Algezir Ultra preparation (tablets):
- with simultaneous use, the possibility of certain changes in the pharmacokinetic parameters of diazepam is provided;
- if this drug is used simultaneously with caffeine, the effect of naproxen may be enhanced;
- when combined with lithium carbonate , it is possible to increase the concentration of lithium in the blood plasma;
- combination with methotrexate increases the degree of toxicity of this substance;
- when Algezir Ultra is used simultaneously with probenecid, the total concentration of naproxen in the blood plasma decreases;
- simultaneous use with salicylamide can enhance the effect of this substance.
There is evidence indicating that if this drug is used simultaneously with morphine, then ultimately it can lead to the development of myoclonus. Also, with simultaneous use with prednisone, a significant increase in the concentration of this substance in blood plasma is observed. Among other things, simultaneous use with furosemide, which provides for a decrease in the diuretic effect of this substance, is also separately noted. This is noted about such a tool as the drug "Algezir Ultra", reviews. The instruction also indicates this feature of the medication.
Lactation and pregnancy
It is recommended to use this drug with extreme caution for pregnant or lactating women, and in particular this applies to those who are currently in the first or third trimester. The whole point here is that after taking this drug, naproxen begins to penetrate the placental barrier, and subsequently is excreted in small quantities with breast milk.
Side effects
It is worth noting a few side effects that are indicated by the instructions for use for the drug “Algezir Ultra”. Descriptions in this case are provided for different groups of bodies:
- Digestive system. During the reception, vomiting, nausea, a feeling of discomfort in the epigastric region may be present. In rare cases, erosive and ulcerative lesions of the gastrointestinal tract, as well as various violations of the liver and bleeding, are manifested.
- Central nervous system. When using the drug, some patients experience drowsiness, headache, as well as a slowdown in the speed of psychomotor reactions. In extremely rare cases, when using this tool, various hearing impairments appear, as indicated by the instructions for use of the Algezir Ultra preparation. The abstract does not describe in detail this feature of use.
- Hematopoietic system. Extremely rarely, the use of the drug leads to the occurrence of granulocytopenia and thrombocytopenia, as well as hemolytic or aplastic anemia.
- Respiratory system. In rare cases, eosinophilic pneumonia may develop .
- Urinary system. In rare cases, various impaired renal function may occur.
- Allergic reactions. During a study, a certain group of patients experienced urticaria, skin rash and Quincke's edema, which is a fairly common allergic reaction to the various components that make up the drug, as mentioned in the Algezir Ultra instructions for use. Treatment in this case may not be suspended.
Among other things, special attention is also paid to the fact that in the case of rectal use there is a risk of mucous secretions with small amounts of blood or the appearance of painful bowel movements.
When is it used?
In the past few years, modern doctors quite often began to prescribe this medicine to their patients in the process of treating a wide variety of diseases, including those described in the instructions for use by Algesir Ultra. The price of this drug is affordable for almost everyone, and therefore it is often prescribed instead of the predominant majority of similar drugs.
In particular, it is worth noting several basic ailments, in the treatment of which it is used most actively:
- osteoarthritis;
- rheumatoid arthritis;
- ankylosing spondylitis;
- exacerbations of gout;
- joint syndrome;
- neuralgia;
- myalgia;
- pain in the spine;
- traumatic inflammation of the soft tissues or the musculoskeletal system.
Among other things, Algezir Ultra is quite common as an adjunct in the treatment of various infectious and inflammatory diseases of the ENT organs, primary dysmenorrhea, adnexitis, as well as toothaches and headaches.
Contraindications
There are several cases in which this remedy is not recommended for use, and this is indicated by the instructions for use (description) to the Algezir Ultra preparation. Doctors' reviews also quite often indicate that this drug is highly not recommended for use in the following situations:
- “Aspirin triad”;
- all kinds of erosive and ulcerative lesions in the gastrointestinal tract;
- pronounced impaired renal function;
- violation of the hematopoietic system;
- pronounced violations in the functions of the liver;
- Too high sensitivity to naproxen and other substances that make up this drug.
Among other things, the use of this tool is not recommended for children under the age of one year, as evidenced by the instruction Algezir Ultra. The price of this tool is 85-90 rubles. for 10 tablets.
special instructions
Extremely carefully, this tool should be used in the process of treating various diseases of the kidneys and liver, a gastrointestinal tract in the anamnesis, as well as with heart failure, arterial hypertension or the presence of dyspeptic symptoms. In particular, it is imperative that you consult with your doctor about whether you can use the drug after significant surgical interventions.
During treatment, it is always necessary to maintain systematic control over the work of the kidneys and liver, as well as the picture of peripheral blood. If it is necessary to determine the degree of concentration of 17-ketosteroids, naproxen will need to be canceled an additional 48 hours before the expected date of the study.
Special attention should be paid to the fact that taking this medication affects the ability to drive vehicles and control various mechanisms. In this regard, it is best to refrain from any potentially dangerous activities that are directly related to the need for concentration and increased speed of psychomotor reactions, while Algesir Ultra is used. Instructions for use with the drug separately emphasize this point.