Cardiovascular diseases occupy a leading position among other diseases. Thousands of Russians suffer from them. This is what Biprol helps from. It prevents the development of the disease, relieves heart attacks and is affordable.
Release form and composition
Diseases of the heart and blood vessels - this is what Biprol helps with. The drug is produced in coated tablets. The active substance is bisoprolol fumarate in a dose of 5 and 10 mg.
Additional ingredients are: corn starch, microcrystalline cellulose, aerosil, crospovidone, ludipress and magnesium stearate. The shell contains polyethylene glycol, hypromellose, talc, titanium dioxide, tropeolin O.
In a cardboard box are 30 or 50 tablets.
Pharmacological properties
The drug belongs to selective beta1-blockers, does not have internal sympathomimetic activity and is not endowed with membrane-stabilizing qualities.
Bisoprolol fumarate reduces the manifestation of plasma renin, reduces the need for oxygen in the myocardium, as well as the heart rate both at rest and during physical exertion. It has hypotensive, antiarrhythmic and antianginal properties. In low concentrations, it resists the β1-adrenergic receptors of the heart apparatus, reduces the formation of cAMP from ATP and the flow of calcium ions inside the cells activated by catecholamines. Used in large doses, it exhibits beta2-blocking properties.
The total peripheral vascular resistance at the very beginning of tablet use, especially on the first day, rises, but after 1-3 days it comes to its original state, and with prolonged use it decreases.
The antihypertensive property determines a decrease in the minute amount of blood, autonomous activation of peripheral vessels, reduces the activity of the renin-angiotensin-aldosterone complex. It is characterized by reconstruction of susceptibility to lowering blood pressure and effects on the central nervous system. With an increase in blood pressure, the primary result is observed at 2-5 days, and the condition stabilizes after 30-60 days.
An antianginal property is manifested in a decrease in myocardial oxygen demand due to a decrease in heart rate and muscle contractility, an increase in diastole and progress in myocardial perfusion, as well as an increase in the finishing pressure of the diastolic character in the left ventricle and an increase in the elasticity of the muscles of both ventricles.
The antiarrhythmic characteristic is associated with the removal of arrhythmogenic causes, an increase in the number of cAMP, a decrease in the excitation of sinus and ectopic pacemakers, and inhibition of AV conduction.
The use of the drug in medium therapeutic doses does not have such a strong effect on organs with β2-adrenergic receptors. The drug in this amount does not affect the carbohydrate metabolism and does not stop the release of sodium ions from the body. High doses of the drug inhibit subtypes of β-adrenergic receptors.
The above description of the properties of bisoprolol fumarate shows in detail what Biprol helps with.
Pharmacokinetics
The medicine "Biprol" is dissolved in the gastrointestinal tract by 80-90%. Its absorption is not affected by food intake. The highest concentration of the active substance in the blood is observed after 1-3 hours. Connection with blood proteins occurs at 30%. In small quantities, the active substance penetrates the blood-brain and placental barrier, a small part is excreted in breast milk of the mother.
Metabolized in the liver. The elimination half-life is 10-12 hours. Half of the active substance leaves unchanged in the urine, and 2% in the bile.
What helps Biprol
The drug is prescribed for arterial hypertension. With hypertension, a steady increase in blood pressure is observed. “Biprol” also has indications for use in coronary heart disease, where it is most often used for prophylactic purposes in cases of angina pectoris.
Contraindications
It is necessary to take the drug "Biprol" strictly according to the doctor's prescription. Indications for its use are described above, and now about contraindications. These include shock of various genesis, including cardiogenic. You can not drink tablets with collapse and pulmonary edema. The ban is acute and chronic heart failure, as well as II-III stages of development of AV block. A contraindication is the diagnosis of sick sinus syndrome , cardiomegaly, bradycardia, arterial hypotension and Prinzmetal angina. The drug is not prescribed for asthma of the bronchopulmonary apparatus, chronic obstructive pulmonary disease and when taking MAO inhibitors. It should not be used by patients with peripheral circulation diseases, with pheochromocytoma, when metabolic acidosis occurs , and individuals under eighteen years of age. It is forbidden to patients with hypersensitivity to the active substance and other components of the drug.
Biprol is prescribed with caution to patients suffering from liver failure, as well as to people with chronic renal failure, patients with myasthenia gravis and thyrotoxicosis. Caution should be exercised by persons with diabetes mellitus, I degree of AV blockade and patients with depression. Only in special cases, it is prescribed for psoriasis and patients of retirement age.
Instructions for use
When using the medicine "Biprol", indications for use should be taken into account. Tablets are drunk on an empty stomach in the morning. They are not chewed and washed down with water.
The drug is consumed in 5 ml once a day. If the need arose, the dosage is increased to 10 mg, which they drink once a day. A maximum of 20 mg can be taken per day.
For individuals with impaired renal function, as well as for patients with liver disease, the maximum dose is 10 mg per day.
Special conditions
Constant medical monitoring of patients using Biprol should be carried out. What the medicine helps from has been described above, and now about how to observe the condition of the patient drinking these tablets. First of all, heart rate and pressure should be measured, these indicators are very important at the very beginning of therapy. An electrocardiogram is made to the patient, and a blood test for glucose level is taken in patients with diabetes mellitus. In the elderly, the condition of the renal system is monitored.
The work of external respiration in patients with a history of pulmonary diseases is examined.
Patients must learn to count their own heart rate, and if the rate is less than 50 beats per minute, then you should seek medical help.
During therapy, tear fluid production may decrease, which should be considered by contact lens owners. In people with diabetes, the medicine may hide tachycardia provoked by hypoglycemia. The drug does not increase the hypoglycemia that occurs when using insulin and does not inhibit the reimbursement of glucose concentration to the normal level in the blood.
Before surgery, the drug is canceled two days before general anesthesia. If the patient nevertheless took the pill before surgery, then the medicine for anesthesia should have a minimum negative inotropic property.
Cardioselective adrenergic blockers are prescribed for people with bronchospastic diseases with the inappropriateness of using other antihypertensive drugs. An overdose can provoke bronchospasm.
In elderly people with bradycardia and with a clear decrease in blood pressure, AV blockade, the concentration of the active substance should be reduced or therapy with Biprol should be completely stopped. It is also necessary to stop treatment if a patient develops a depression.
Do not stop therapy if there is a danger of the progression of severe arrhythmias and myocardial infarction. Refusal to use the drug is carried out gradually, reducing the norm for 14 days. The tablets are canceled in advance if a laboratory study of urine and blood is planned for the presence of normetanephrine, catecholamines, etc.
Side effects
It is necessary to use the drug "Biprol" only as prescribed by the doctor. The use of tablets in doses exceeding the recommended ones, as well as in diseases in which the use of this medicine is prohibited, leads to the appearance of side effects.
With prolonged therapy, there is increased fatigue, headache, weakness, sleep disturbance, depression, confusion, hallucinations, anxiety, tremors, asthenia and myasthenia gravis. In patients, a violation of the visual apparatus occurs, expressed in a decrease in lacrimal fluid, excessive dry eyes and their soreness. Conjunctivitis appears.
In the treatment of patients noted: sinus bradycardia, excessive heart rate and malfunctions in the conductivity of the myocardium, as well as AV block, arrhythmia, aggravation of the condition of a patient suffering from heart failure in a chronic form. Sometimes there is a weakening of myocardial contractility and lowering blood pressure, hypotension in the orthostatic form, pain in the sternum, withdrawal syndrome, which was accompanied by more severe bouts of angina pectoris and an increase in blood pressure.
Excessive dry mouth, diarrhea, nausea, abdominal pain, constipation, etc. were observed. In some cases, nasal congestion and shortness of breath were recorded. Sometimes patients were worried about allergies in the form of rash, itching and urticaria. Excessive sweating, hyperemia of the epidermis, exanthema, psoriasis were observed.
Overdose
We strongly recommend that you observe the prescribed dose when taking the medicine "Biprol" instructions for use. Reviews say that this drug is worthy of attention. It is effective and inexpensive, but if you use a dose in excess of the prescribed dose, overdose symptoms may occur. They are expressed in the form of arrhythmias, ventricular extrasystoles , obvious bradycardia. An overdose can cause AV blockade, a marked decrease in blood pressure, heart failure, cyanosis of the nail plate, bronchospasm, convulsions, dizziness, difficulty breathing.
In case of an overdose, gastric lavage is done and adsorbents are prescribed. Symptomatic treatment is performed. If there is an AV block, then do 1-2 mg of atropine, which can be replaced by epinephrine or by installing a temporary pacemaker. With low blood pressure, a person is placed in the Trendelenburg position and plasma-replacing solutions are administered intravenously . In heart failure, diuretics, glycosides, or glucagon are recommended. When convulsions are administered "Diazepam", bronchospasm is removed by inhalation.
Storage conditions and shelf life
It is advised not to use the medicine "Biprol" after the expiration date, the instructions for use. Analogs are affordable and can be found in any pharmacy.
The shelf life of the drug is three years from the date of manufacture. The drug should be stored in a cool, dark place inaccessible to children at a temperature not exceeding +25 ° C.
Biprol: analogues
If the drug for one reason or another does not fit the body, then instead of it you can find a medicine with similar properties. Replace "Biprol" (analogues are similar in active ingredient and effect) only after consulting your doctor with the following medicines: "Tirez", "Aritel", "Niperten", "Bidop", "Coronal", "Bisogamma", "Cordinorm "," Bisoprol "," Concor. " The difference between the means is only in price and producer.
Cost
The price of the drug is about 150 rubles for 30 tablets of 10 mg. 5 mg tablets cost about 80 rubles for 30 pieces.
Patient Reviews
In almost all situations, Biprol can replace analogues. Reviews about this drug are mostly positive. Some individuals chose to replace the original, as it has many side effects. Those who nevertheless decided to take Biprol well tolerated the medicine. They noted its high efficiency and good results. There are patients who have replaced the imported Concor.
Specialists about the drug respond well. They say that it relieves angina attacks well and rarely causes side effects. This is mainly a headache.
Biprol is one of the most popular and effective means. With the correct appointment and strict adherence to all the doctor's prescriptions, it gives a lasting and lasting effect.