With the onset of winter colds, everyone risks catching an infection. To avoid such a nuisance, preventive measures should be taken regularly to strengthen your health and the immune system as a whole.
Unfortunately, not everyone knows what actions need to be taken to protect themselves and their family members from colds and flu. Therefore, when changing seasons, a lot of people get sick.
At the first symptoms of a cold, you should consult a therapist. The doctor must prescribe special antipyretic and analgesic drugs to the patient. They normalize the patient’s body temperature and eliminate all signs of the disease.
One of the most effective remedies for colds and flu is the grippo medication. Instructions, methods of use, the composition of this medication are presented below.
Release form, description, composition and packaging
What substances does the medicine "Grippo" contain? The instructions and description of the drug state that it contains caffeine, paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride.
In addition to the active substances, the medication in question contains additional components in the form of croscarmellose sodium, microcrystalline cellulose and magnesium stearate.
The drug "Grippo", the instructions for use of which will be discussed below, is available in the form of biconvex and capsule-shaped tablets of white color. They are packed in blisters or strips, which are placed in bundles of paper.
Pharmacology of the drug
What are Grippo tablets? Instructions for use indicate that this is a combined preparation, the effectiveness of which is due to the ingredients that make up its composition. Consider the properties of each of the components in more detail.
Paracetamol is called an analgesic-antipyretic. It has analgesic and antipyretic properties. The action of paracetamol is associated with its effect on the hypothalamic center of thermoregulation, as well as its ability to inhibit the synthesis of prostaglandins.
Caffeine is an alkaloid belonging to the group of methylxanthines. It is able to stimulate the vascular and respiratory centers, as well as improve the emotional and physical condition of a person. Due to these properties, in the treatment of infectious diseases, the manifestations of asthenia are significantly reduced. Caffeine also improves the analgesic effect of paracetamol.
Chlorpheniramine maleate is a so-called antihistamine. It reduces allergic reactions in infectious diseases. This component competitively blocks H1-histamine receptors, eliminates runny nose, pain in the eyes and itching in the nose.
Phenylephrine hydrochloride is a sympathomimetic. It reduces hyperemia and edema in the respiratory tract (in the upper sections) and sinuses. This helps to improve nasal breathing.
It should also be noted that the component in question is capable of stimulating alpha adrenergic receptors. Due to this, there is a decrease in the permeability of peripheral vessels and their narrowing, as a result of which the formation of mucous secretions is markedly reduced.
Indications
From what patients are prescribed such a drug as "Grippo"? Instructions for use (the indications of this remedy will be presented right now) indicate that this medication is intended for symptomatic treatment of influenza and other acute respiratory diseases that appear in the form of nasal congestion, headache, fever, pain in the muscles and eyes, sinusitis, sore throat, rhinitis and cough.
Contraindications
Are there any contraindications for the Gripgo tablets? Instructions for use of the drug reports that there are a huge number of prohibitions on this drug. Consider their list right now:
- hyperbilirubinemia;
- hepatic or renal failure (severe);
- severe cardiovascular disease;
- hyperthyroidism, pheochromocytoma, thyrotoxicosis;
- hypersensitivity to drug substances;
- exacerbation of peptic ulcer in the digestive tract;
- pyloroduodenal obstruction, gastric ulcer with stenosis;
- lung diseases
- hematopoiesis, unstable angina pectoris, pronounced atherosclerosis, anemia, acute myocardial infarction, severe leukopenia, bradycardia, severe cardiac conduction disorders, arrhythmias, heart failure (decompensated), organic circulatory system lesions, severe coronary heart disease, flowing form;
- glaucoma;
- severe arterial hypertension, increased arousal, insomnia;
- epilepsy;
- prostate adenoma with residual urine, acute urinary retention with prostatic hypertrophy, obstruction of the bladder;
- acute pancreatitis;
- diabetes;
- glucose-6-phosphate dehydrogenase deficiency;
- lactation and pregnancy;
- alcohol abuse, treatment with beta-blockers or tricyclic antidepressants, treatment with MAO inhibitors and two weeks after completion of their intake;
- age up to 12 years;
- conditions characterized by sleep disturbance or increased arousal;
- increased QT interval congenital or prolonged medication, increasing the QT interval.
Gripgo medicine: instruction for use
Description, indications of this medication were presented above.
According to the instructions, the tablets in question must be taken by adults and adolescents from 12 years old. Their dosage is 1 piece four times a day.
The maximum dose of the drug is 4 tablets per day. The duration of treatment is 3-5 days.
Side effects
Can the drug "Grippo" (tablets) cause undesirable reactions? Instructions for use report that this tool quite often causes various side effects. Consider them right now:
- angioedema, skin allergic reactions, anaphylactic shock;
- skin rashes, itching, erythema multiforme exudative, urticaria, Stevens-Johnson syndrome, toxic epidermal necrolysis ;
- visual disturbances, increased intraocular pressure, accommodation, dry eyes, mydriasis;
- anxiety, dizziness, dyskinesia, headache, irritability, psychomotor agitation, tinnitus, fear, epileptic seizures, disorientation, behavioral changes, irritability, cramps, insomnia, coma, confusion, tremors, drowsiness, depression, tingling and heaviness in the limbs;
- aseptic pyuria, difficulty urinating, nephrotoxicity (papillary and interstitial necrosis, renal colic), urinary retention;
- vomiting, loss of appetite, nausea, hepatonecrosis, heartburn, dry mouth, diarrhea, constipation, epigastric discomfort, flatulence, impaired liver function;
- increased liver enzymes;
- anemia, thrombocytosis, methemoglobinemia, sulfhemoglobinemia, neutrophilic leukocytosis, erythrocytopenia, hyperprothrombinemia;
- tachycardia, reflex bradycardia, arterial hypertension, heart pain, myocardial dystrophy, shortness of breath, palpitations, arrhythmia;
- hypoglycemic coma, hypoglycemia;
- bronchospasm for allergies to NSAIDs and acetylsalicylic acid;
- violation of the metabolism of copper and zinc;
- general weakness, increased sweating, hypoglycemia;
- pancytopenia, neutropenia, aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, the formation of cystine, oxalate and urate stones, the development of diabetes mellitus, pancreatic damage, crystalluria (with long-term use of the drug and in large doses).
Drug overdose
What are the symptoms of an overdose of Gripgo? Instructions for use (the price of the medicine is indicated below) reports that in this case the patient may experience: nausea, cramps, vomiting, abdominal pain that appears after 1-2 days, visual impairment, toxic effects on the kidneys and liver (can cause necrosis), coma, drowsiness, followed by agitation, headache, arterial hypertension, circulatory disorders, bradycardia, dizziness, atropine-like psychosis, rapid breathing, extrasystole, trembling.
Overdose treatment
To treat the above conditions, the patient is washed with a stomach, and also give N-acetylcysteine (an antidote to paracetamol) and enterosorbent. In addition, the patient controls the functions of blood circulation and respiration.
Drug interaction
Can the drug "Grippo" be combined with other medicines? Instructions for use indicate that the simultaneous use of this drug with sleeping pills, analgesics and MAO inhibitors can enhance its inhibitory effect on the nervous system.
The combination of "Grippo" with antidepressants, anticholinergic antispasmodics, angigistamines and antiparkinsonian drugs can cause an atropine-like effect, which is manifested by dry mouth, disturbed accommodation, urinary retention and constipation.
With simultaneous administration with Procarbazine, sympathomimetics, thyroid hormones and Furazolidone, the likelihood of adverse reactions increases.
When combined with nitrates, the effect of the latter is weakened.
It is forbidden to take "Grippo" with other drugs that contain paracetamol, as well as with other NSAIDs and alcohol.
Special recommendations for taking the medicine
What you need to know before using Grippo tablets? The use of impaired renal function (expressed) is prohibited. It should also be noted that you can not exceed the dose recommended by the doctor and use the medication for more than five days in a row. In the evening, tablets should be taken 3 hours before bedtime.
If the signs of the disease have not disappeared five days after the start of treatment, then it should be canceled and consult a doctor.
What other features does the grippo medicine have? Instructions for use states that phenylephrine gives a false positive result in doping control.
During the treatment period, strong coffee, tea and other tonic drinks should not be consumed.
Abrupt drug withdrawal can lead to depression of the nervous system with signs of depression and drowsiness.
With long-term use of tablets, the development of mental dependence is possible.
Analogs and price of medicine
The drug in question (No. 100) costs about 750 rubles. If necessary, it can be replaced with such drugs as Agikold, Antigrippin, Axagripp, Antiflu, Vokasept, Apap, Gripaout, Dolaren, Griposan, Dollar, " Cold-N ”,“ Kaffetin ”,“ Coldrex ”,“ Lorkold ”,“ Combigripp ”,“ Novalgin ”,“ Paralin Extra ”,“ Padevix ”,“ Rinza ”,“ Spazgo ”,“ Solpadein ”,“ Flucoldex ”, Unispaz, Heathflu, Gripeks. Instructions, composition, use, analogues of these funds can significantly differ from the drug we are considering. Therefore, only an experienced doctor should prescribe them.
Consumer Reviews
Now you know the properties of the drug "Grippo." Instructions for use of this medication have been described in detail above.
According to consumers, this medication is very effective in high temperature, drowsiness, sore throat, joints and eyes, as well as asthenia during treatment of SARS. However, when taking this medication, one should not forget about the many adverse reactions that this drug can cause, including if the doses recommended by the doctor are not observed. In addition, the "Grippo" pills have a huge number of different contraindications.