In the article, we consider the instructions and reviews for the drug "Doxycycline".
It is an antibacterial medication that belongs to the group of tetracyclines. It is widely used in the treatment of pathological disorders in the respiratory, urinary tract, intestines and stomach, and other diseases. When using the drug, the instructions contained in the instructions for use should be strictly observed. This will minimize the risk of complications.
Reviews about "Doxycycline" are abundant.
Structure
The main active substance in the composition of the agent is doxycycline, a chemical compound that is a derivative of tetracycline. The preparation is in the form of a monohydrate or hydrochloride. Each dose of the drug may include 100 or 200 mg of the active ingredient. As auxiliary substances are used: sodium EDTA, calcium salts, yellow dyes, lactose.
Cost
The cost may vary depending on the company, its manufacturing, pricing policy of the pharmacy network that distributes it, the region of sale. On average, a package of 10 tablets with a dosage of 100 mg will cost 15 rubles, of 20 tablets with a similar dosage - 25 rubles.
Pharmacological forms
The manufacturer produces the drug in two pharmacological forms:
- Capsules Intended for oral use. Each package can contain 10 or 20 capsules, which are yellow in color and contain 100 mg of doxycycline.
- Powder. Designed for the preparation of an injection solution. It happens in two dosages - 100, 200 mg. Each package contains 5 or 10 ampoules with lyophilisate.
Each package contains instructions for use with Doxycycline. We will consider reviews about the drug later.
Pharmacological effects
Doxycycline is part of a group of antibacterial drugs that have a systemic effect on the body. According to the mechanism of exposure, the drug refers to bacteriostatic drugs. Against the background of its use, the synthesis of the cellular elements of bacteria consisting of protein is inhibited.
Pharmacological effects
- Bacteriostatic effect on bacteria.
- Effect on chlamydia, mycoplasmas, salmonella, causative agents of gonorrhea, streptococcus, rickettsia, clostridia, E. coli, staphylococcus.
The drug has a wide range of effects, which makes it possible to use it to treat many pathologies provoked by sensitive microorganisms.
Indications for use
The drug is indicated for use in patients with:
- Tetanus.
- Gas gangrene.
- Leptospirosis.
- Intestinal amoebiasis.
- Malaria.
- Cholera.
- Ornithosis.
- Tularemia.
- Brucellosis. Therapy of brucellosis involves the combination of "Doxycycline" with other antibiotics.
- Q fever.
- Endocarditis.
- Blue disease.
- Dental diseases such as fluxes and periodontitis, accompanied by infection, suppuration, toothache.
- Typhus.
- Eye damage infectious etymology.
- Acne According to reviews, "Doxycycline" in the treatment of acne is indispensable. It can be used for the antibacterial treatment of acne and acne in patients of any age category.
- Gynecological diseases of infectious etymology, including post-abortion complications provoked by bacteria.
- Syphilis.
- Gonorrhea.
- Pathologies of the rectum, having an infectious nature.
- Prostatitis.
- Urethritis.
- STDs, in particular chlamydia and ureaplasmosis.
- Pathologies of the kidneys and urinary system, provoked by infection. Very often, the drug is prescribed if the patient has pyelonephritis, cystitis.
- Otitis and some other diseases of the ENT organs.
- Chronic bronchitis.
- Chronic sinusitis.
- Sinusitis
- Infections of the respiratory system. "Doxycycline" is highly effective for bacterial colds, tonsillitis, bronchitis, tonsillitis, SARS and other pathologies of a bacterial nature.
- Pneumonia.
Clinical studies show that "Doxycycline" is effective when it is necessary to prevent travelers' diarrhea, leptospirosis, and malaria.
Before using the medicine, a study of the sensitivity of the pathogenic pathogen to the active component is mandatory. After that, the doctor selects the treatment regimen appropriate for the particular patient.
This is indicated in the instructions for use. Reviews about "Doxycycline" are mostly positive.
Contraindications
The medication is not recommended if the patient has the following diseases or physiological conditions:
- Pregnancy. During pregnancy, the use of "Doxycycline" is prohibited, since it can adversely affect the development of the fetus, in particular, inhibit the formation of bone tissue. However, if the benefit to the mother is significantly higher than the expected harm to the fetus, medication is allowed as directed by the doctor.
- Childhood. Doxycycline capsules should not be used if the patient is less than 12 years old, the lyophilisate is contraindicated in children under 8 years of age.
- Lack of functioning of the liver in severe form.
- Porphyria.
- Leukopenia in any form.
- Individual susceptibility to any components that are part of the drug, as well as to antibiotics of the tetracycline group.
Very often prescribed "Doxycycline" for acne. Feedback on this will be presented at the end of the article.
Instruction for use
The capsule preparation should be taken immediately after or during meals. A single dose should be swallowed whole. It is necessary to drink with liquid in large quantities - tea, milk, water. It is not recommended to take the drug before bedtime.
Capsules of the drug are allowed for use in patients from 12 years old. On the first day of therapy, 200 mg of the drug should be taken (100 mg twice a day). In the following days, the dosage is reduced to taking 100 mg once a day.
If the infectious disease is severe or chronic, 200 mg of the drug is recommended throughout the course of therapy. Allowed as a single dose of the entire dose, or divided into two.
The duration of the course of therapy is determined by the doctor, most often it is 10 days. You should not stop taking the drug immediately after the disappearance of unpleasant symptoms. It is important to take the drug a few days after normalization of body temperature and relief of acute symptoms.
For the purpose of acne therapy, 50 mg of the drug should be taken once a day. Duration of admission is up to 12 days. When using analogues, you should choose a tool, the dosage of the active component in which will also be 50 mg. According to reviews, analogues of Doxycycline are no less effective.
For the treatment of malaria and STDs, a double dose of the drug is indicated. The total daily dosage is 400 mg, i.e. 200 mg per dose. The duration of therapy is up to 10 days.
In the prevention of malaria, the daily dose for adult patients is 10 mg, for children from 12 years old - 2 mg of the substance per kilogram of mass. It is important to start taking the drug two days before the expected date of arrival in a potentially dangerous area and continue the entire period of stay, as well as within a month after returning.
Reviews on the use of "Doxycycline" is best studied in advance.
Prevention of cholera involves taking the drug in an amount of 300 mg.
In order to prevent diarrhea of โโtravelers, the drug is taken 200 mg on the first day, 100 mg on the next two days.
In order to prevent leptospirosis, it is recommended to take 200 mg of the drug once a week for the entire period of stay in a potentially dangerous area.
"Doxycycline" in the form of a lyophilisate is recommended for use if the patient is diagnosed with an infectious pathology with a severe course. Adult patients are advised to use 200 mg of the drug per day. The lyophilisate solution can be used both for intravenous injection and for intravenous infusion. The most commonly used treatment regimen is a double administration of 100 mg of the substance per day.
For children from 8 years of age, the dosage should be calculated in a special way: on the first day of therapy, 4 mg / kg should be used. The introduction is made once or twice a day. From the second day of treatment, it is indicated to administer once or twice from 2 to 4 mg / kg.
Intramuscular administration of the solution is prohibited.
Overdose
Overdose cases are extremely rare. An overdose of a substance in the form of pancreatitis and kidney damage is manifested. In addition, the negative effects of the drug may increase. Doctors' reviews of Doxycycline confirm this.
If symptoms of an overdose are found, the patient should stop using the drug, rinse the stomach, introduce calcium salts.
It is possible to prevent the development of negative symptoms against an overdose by strictly following the doctor's recommendations.
Side effects
Compared with other tetracycline antibiotics, side effects are quite rare. According to reviews of Doxycycline and instructions, they are most often expressed in the following manifestations:
- Liver failure.
- Drowsiness.
- The state of depression.
- Cramps.
- Muscle and joint pain.
- Change the color of tooth enamel. A similar negative effect is observed if Doxycycline is used in the second and third trimester of pregnancy in children under 12 years of age.
- Candidiasis.
- Headache.
- Visual impairment. If such a negative effect is detected, the drug should be stopped.
- Itchy skin.
- Skin rashes.
- Ulcerative lesions in the intestines and stomach.
- Photosensitivity.
- Dyspepsia.
This is confirmed by the instructions for use and reviews of Doxycycline tablets.
If the patient has any of these indicated side effects while taking the drug, he should consult a doctor and report it.
Interaction with other drugs
The effectiveness of the drug decreases while taking it with antacids, sorbents, carbamazepine, barbiturates, phenytoin, iron preparations, magnesium and calcium preparations.
If it is necessary to take these drugs, the interval between their use and the use of Doxycycline should be at least two hours.
Under the influence of the drug, the effect of lithium and cyclosporins is enhanced.
The drug is able to inhibit the effects of oral contraceptives.
With parallel use, the effectiveness of cephalosporin and penicillin antibiotics decreases. When combined with anticoagulants, their effectiveness increases.
Experts do not recommend combining Doxycycline with ethanol, methotrexate, theophylline, vitamin A.
All possible drug interactions should be considered to make therapy as effective as possible.
So it is said in the instructions for use with Doxycycline. Reviews and analogues are of interest to many. Let's consider them further.
Analogs
If you need to replace the drug and it is agreed with the doctor, then it can be done using the following drugs: Doxycycline Solutab (is a more modern, soluble form of the usual Doxycycline), Doxa-M-Retinopharm, Vibramycin, Unidox Solutab, Doksibene.
All of these analogues of the drug have differences in pharmacological forms and manufacturers. Some sources, relying on clinical studies, argue that Doxycycline, which involves preliminary dissolution in water, is more effective. The soluble form of the antibiotic has less negative effect on the digestive system.
In addition, Doxycycline can be replaced with the following drugs belonging to the tetracycline group:
- "Tigecycline" ("Tigacil").
- "Tetracycline." It is a more toxic drug. At Doxycycline, the negative effects are less pronounced, that is, it is safer.
- Oleterin. The combined drug, which contains oleandomycin and tetracycline.
Terms of sale and storage
Doxycycline is able to maintain its therapeutic properties for three years from the date of manufacture. The use of a drug with an expired shelf life is strictly prohibited.
The medicine is an active antimicrobial drug, and therefore pharmacies release it only if there is a medical prescription in Latin. It is important to note that the recipe must contain the INN of the drug.
Storage should be carried out in rooms protected from light and moisture, the temperature in which should not rise above 25 degrees Celsius.
This is confirmed by the instruction for Doxycycline tablets. According to reviews, this tool is well tolerated in most cases.
Special instructions for use
In order to prevent the development of candidiasis, it is recommended to combine Doxycycline therapy with the use of antifungal medications such as Nystatin, Fluconazole, as well as probiotics.
Against the background of the use of the drug, undesirable reactions that interfere with the activities associated with driving a car or complex machinery do not develop.
If the patient has lactose intolerance, he should use Doxycycline with extreme caution.
If you develop any manifestations that indicate a violation of the gastrointestinal tract and damage to the intestines or stomach, the drug should be stopped immediately and consult a medical institution.
Reviews of "Doxycycline" in gynecology and other fields are presented below.
Reviews
The medication has been used to treat a variety of inflammatory processes for a long time. Among patients and specialists in various medical fields, he has proven himself well. Doctors of different profiles mark it as a drug that is highly effective, but recall that, like any other medication, it is able to provoke the spontaneous development of a variety of negative effects. It is with this ability that strict contraindications are associated (childhood, lactation, pregnancy). However, doctors report that, following the recommended treatment regimen, the risk of unwanted effects is significantly reduced.
An effective medicine is also considered in gynecology. It is often used in the treatment of sexually transmitted diseases.
The drug also helps against acne: the skin becomes clean. True, the reviews suggest that the course is quite long, therefore it often leads to side effects from the gastrointestinal tract.
As positive qualities of the drug, patients note its more than affordable cost and a rather high level of effectiveness. However, negative reviews about Doxycycline are quite common. They are most often associated with the ability to provoke side effects.
It is important to remember that taking the drug, in fact, like any other medication, should only be recommended by a doctor.
We reviewed the instructions and reviews about Doxycycline.