"Midokalm-Richter" is an effective modern muscle relaxant designed to relieve pain of various etiologies and localizations. The drug is available in tablet and injectable form for parenteral use called Midokalm-Richter (injections). Reviews of many patients allow us to conclude that the medicine is very effective in reducing muscle hypertonicity. The drug has an effect on the central nervous system, therefore it is not recommended to take it without a doctor’s prescription. Today, many readers are interested in the question of what is Midokalm-Richter (injections)? Instructions for its use, indications and contraindications for use are described below.
Biochemical composition of the drug
The composition of the medication includes a complex of biologically active and auxiliary substances:
- tolperisone hydrochloride (bioactive compound);
- lidocaine hydrochloride ;
- diethylene glycol monoethylether;
- injection water;
- methyl paraben.
Pharmacodynamics
The exact mechanism of action of the drug "Midokalm-Richter" (injections) on the human body has not yet been deciphered. Scientists suggest that due to the effect of the drug on afferent fibers, poly- and monosynaptic reflexes of the spinal cord are blocked. The bioactive components of Midokalm-Richter inhibit the release of the transmitter by blocking the entry of Ca 2+ ions into the synapses. Tolperisone hydrochloride exhibits a weak antispasmodic and adrenergic blocking effect. And this is not all indications for use for the Midokalm-Richter preparation. It activates peripheral blood circulation, improves the metabolism of substances in the pathological zone.
Pharmacokinetics
After oral use, the drug is well adsorbed by the mucous membrane of the small intestine. The maximum concentration in the patient’s blood is observed after half an hour, bioavailability for oral administration of the drug is about 20%. Tolperisone hydrochloride is metabolized in the tissues of the liver and kidneys. The release of metabolites occurs mainly through the kidneys.
"Midokalm-Richter": instructions for use
Given the pharmacodynamics of the drug, it is prescribed for very many pathologies associated with hypertonicity of muscle fibers. Most experts recommend starting treatment with injections, and then moving on to taking the tablet form of the drug. This treatment regimen guarantees a quick recovery of the patient. The medication is prescribed for the following pathologies:
- encephalopathy;
- ischemic stroke;
- thrombophlebitis of the lower extremities;
- diabetic angiopathies;
- myasthenia gravis central origin;
- encephalitis;
- obliterating endarteritis;
- psorioid arthritis;
- deforming osteoarthrosis;
- pain caused by osteochondrosis or radiculitis;
- muscle dystonia;
- lumbago;
- menstrual cramps;
- Little's disease in children;
- intervertebral hernia;
- rheumatoid polyarthritis;
- renal colic;
- hemorrhoids;
- vascular sclerosis;
- spondylitis;
- cholelithiasis;
- the threat of miscarriage due to myometrial hypertonicity;
- autoimmune pathologies (Raynaud's syndrome, systemic scleroderma , etc.);
- vascular sclerosis;
- acrocyanosis.
Contraindications
If you decide to use Midokalm-Richter (injections), the instructions for use indicate that this medicine should not be used in the following cases:
- the period of bearing a child and breastfeeding;
- severe myasthenia gravis;
- age category up to 18 years;
- hypersensitivity to the ingredients of the drug.
The main analogues of the drug
The modern pharmaceutical market is famous for a wide range of medicines. For almost every drug, you can choose an analog that is similar in mechanism of action. “Midokalm” was not an exception - a megapopular medication, there are many analogues of it:
- Sirdalud;
- "Tolperizon";
- Tolperil;
- Mefidol;
- "Lyorezal";
- Miolgin;
- "Baclofen."
Before replacing Midokalm-Richter (the instruction warns about this), you need to consult your doctor, as only he can make a qualified selection of this or that medication.
Surdalud
One of the most popular analogues of Midokalm. This is a potent remedy that can be taken once a day, it effectively relieves even the most severe pains. When taking the drug, it should be borne in mind that it can cause excessive fatigue and drowsiness.
Tolperizon
The presented preparation relates to muscle relaxants of central action. Often prescribed for the treatment of muscle hypertonicity, obliterating vascular disease. The specified tool is approximately two times cheaper than the original.
Miolgin
The analgesic and antipyretic effect of the drug is due to the presence of paracetamol in its composition. "Myolgin" is prescribed for neuralgia, sprains and muscle strain. This is a fairly effective drug for headaches. Most specialists do not recommend taking this medicine for patients under the age of 18 years, nursing mothers and pregnant women.
"Baclofen"
This remedy is prescribed in extreme cases, since it has a number of side effects. It is important to remember that when choosing a particular drug analogue, just reading the instructions for use is not enough. You need to choose a medication very carefully, strictly following the instructions of your doctor.
Side effects
Is there a side effect of a drug like Midocalm Richter? Instructions for use do not exclude the development of side effects. It:
- allergy;
- nausea;
- anorexia;
- fatigue;
- itchy skin;
- vomiting
- flatulence, diarrhea;
- loss of balance, tinnitus;
- intense thirst;
- arterial hypotension;
- the appearance of intoxication;
- Quincke's edema;
- severe pain in the limbs;
- dyspeptic and dyspeptic disorders;
- muscle weakness;
- headache;
- nose bleed;
- erimatous rashes;
- tachycardia;
- hyperemia of the skin;
- shortness of breath, shortness of breath;
- rarely anaphylactic shock;
- osteopenia
- excessive drowsiness;
- decreased physical activity;
- Depression
- increased blood creatinine;
- violation of the activity of liver transaminases (AST, ALT);
- visual disturbances.
Drug overdose
There is not so much data on an overdose of Midokalm-Richter. The drug is characterized by a broad therapeutic index. Preclinical studies have shown that with the introduction of the drug in doses significantly exceeding the recommended therapeutic, the following symptoms are observed:
- ataxia;
- shortness of breath (up to its stop);
- tonic convulsive seizures.
It is worth noting that there are no specific antidotes that neutralize the effect of tolperisone hydrochloride. In case of an overdose, immediate medical attention (gastric lavage) is indicated. The following is symptomatic and supportive therapy.
Interaction with other medicines
There are no studies on the compatibility of Midokalm with other medicines, therefore, before administration, the solution should not be mixed in the same syringe with other medicines.
The use of "Midokalm-Richter" is allowed with sedative, hypnotics, as well as ethanol-containing drugs. If necessary, it can be used in conjunction with other muscle relaxants, but in this case the daily dose of the bioactive substance will need to be reduced.
"Midokalm" enhances the effects of niflumic acid, as well as other NSAIDs, because of which the dose of the latter should be reduced when combined with the specified medication. The pharmacological action of Midokalm is enhanced by the following medications:
- clonidine;
- muscle relaxants of peripheral action;
- drugs used for general anesthesia;
- psychotropic medicines.
Midokalm Richter (injections) reviews
Many people are interested in the question of what “Midokalm” actually is. Instructions for use, the cost of the medicine, indications and contraindications - these, of course, are the main criteria for evaluating the drug. Nevertheless, it is worth reading the opinions of doctors and patients on this subject. Among doctors there is an opinion that "Midokalm-Richter" is one of the best modern muscle relaxants. The patient reviews in this case coincide with the opinion of experts, since the medicine is characterized by high efficiency, good tolerance and reliable relief of pain of various localization and etiology. In most cases (from 85 to 95%), reviews about the drug are positive. You can find rare negative reviews that indicate that treatment with the specified medication is not effective enough. The drug "Midokalm-Richter", the indications for the use of which were considered in this article, is dispensed strictly according to the prescription. In the event of any complications, the patient should consult a doctor.