Is a medicine like Wazonite 600 effective? You can find reviews about this drug a bit further. Also, the materials of this article provide information on how to take this medication, in which cases it is prescribed, and in which it is forbidden.
Composition and shape
In what form is the medicine "Vazonit" produced? Reviews report that this product can be purchased in the form of elongated white and biconvex tablets with a risk on both sides. They have a prolonged action, as well as film-coated and placed in blisters that are in cardboard packaging.
The composition of the medication under consideration includes pentoxifylline (the active substance) and such auxiliary elements as crospovidone, hypromellose 15000 cP, colloidal silicon dioxide, microcrystalline cellulose and magnesium stearate.
As for the tablet shell (film), it consists of macrogol 6000, talc, titanium dioxide, 5 cP hypromellose and polyacrylic acid in the form of a 30% dispersion.
Pharmacology
What is a drug like Wazonite 600? Reviews of doctors say that this tool is able to provide the following actions:
- protect the walls of blood vessels from adverse effects (that is, have an angioprotective effect);
- improve blood microcirculation in places of impaired blood circulation (due to improved rheological properties of blood, or the so-called fluidity);
- prevent thrombosis (that is, have an antiaggregatory effect);
- to relax the smooth muscles of the walls of blood vessels (that is, have a vasodilating effect);
- supply tissue with oxygen.
Mechanism of action
What is the effectiveness of Wazonit 600 based on? Reviews say that the active component of this medication is able to improve blood circulation in small vessels and in those places where it is impaired. This process occurs due to improved blood flow, as well as the expansion of small capillaries.
According to experts, blood fluidity increases due to the restoration of the normal form of platelets and red blood cells, as well as the suppression of the bonding process, followed by the formation of a blood clot.
How does the drug "Vazonit"? Reviews claim that after taking this medication in the blood, the level of fibrinogen protein significantly decreases. By the way, it is the last element that takes part in the formation of blood clots, and also enhances fibrinolysis, that is, resolves clumps that clump together. It should be noted that the expansion of capillaries improves blood circulation of all interested tissues.
Features of the medication
What is remarkable means "Vazonit" (tablets)? Reviews report that by supplying tissue with oxygen, this drug contributes to a significant improvement in cellular metabolism, as well as the restoration of normal functioning of all internal organs and systems.
As you know, with a decrease in patency of arteries in the periphery, which occurs, for example, in the process of developing atherosclerosis, an improvement in blood circulation in the affected limbs makes it easier for the patient to walk. Also, he spasms of the calf muscles decrease or completely disappear.
Kinetics
Is the drug “Vazonit” absorbed into the bloodstream? Instructions, reviews claim that after taking the pill inside, its active element is gradually and almost completely absorbed from the digestive tract. At the same time, it provides a long-term effect of the medication.
After absorption, pentoxifylline undergoes metabolism in the liver, resulting in the formation of pharmacologically active metabolic products. Their highest concentration in the systemic circulation is reached after 4 hours, and the therapeutic effect persists for half a day.
The drug in question is excreted in the urine in the form of metabolic products. Also, some of the medication may be excreted in breast milk and feces.
In severe renal impairment, pentoxifylline is excreted more slowly. This requires a reduction in the dose of the drug. With impaired liver function, the patient's bioavailability increases, which also requires a review of the standard therapy regimen.
Indications
What diseases does the “Vasonit” drug most effectively manifest itself in? Reviews of patients claim that this tool helped them well in the following conditions:
- impaired blood circulation of the brain associated with its insufficient supply of O 2 , as well as a change in vascular patency;
- arterial circulation disorders associated with atherosclerosis, inflammation of the walls of blood vessels, diabetes mellitus, Raynaud's disease, as well as against the background of gangrene and frostbite;
- as part of combination therapy for the effects of ischemic stroke, which are accompanied by impaired concentration of attention and intelligence;
- disorders of venous circulation against the background of thrombophlebitis, varicose veins and the formation of trophic ulcers;
- metabolic and dystrophic disorders of the brain;
- hearing and visual impairment associated with impaired circulation in these areas.
Bans on admission
In what cases is it forbidden to take Vazonit medicine? Reviews indicate the following contraindications:
- myocardial infarction in the acute period;
- impaired vision, which is associated with hemorrhages;
- cerebral hemorrhages (i.e. with hemorrhagic stroke);
- any significant bleeding;
- pregnancy and lactation;
- minor age;
- individual intolerance to the components of the drug.
Cautious appointment
With extreme caution, the pills in question are prescribed for atherosclerosis of the vessels of the heart and brain, low blood pressure, irregular heart rate, circulatory system, kidney and liver disorders, in the postoperative period, with gastrointestinal ulcer, increased bleeding, as well as in old age.
Tablets "Vazonit": instructions for use
Reviews of experts report that this drug is highly effective only if it was taken as recommended by a doctor or as directed. According to the latter, the medication in question should be consumed 600 mg twice a day after meals, washed down with water and not chewing.
For individual patients, the dosage of the drug, as well as the duration of its administration, are selected individually.
Now you know how to take the medication "Vazonit". How long to drink with thromboangiitis? The reviews say that the duration of therapy, as well as the dosage regimen for such a disease, is set by the doctor individually, depending on the clinic and the resulting therapeutic effect.
Adverse reactions
Does the drug "Wazonit" cause undesirable consequences? Reviews report that this medication contributes to the appearance of many side effects from the internal organs and systems. Consider the most common ones right now.
- severe dizziness, headache, fainting, cramps, drowsiness, meningitis, insomnia;
- increased heart rate, heart pain, heart rhythm disturbances, decreased blood pressure;
- loss of fields of peripheral vision, visual impairment;
- pain in the right hypochondrium, transient abnormalities in the liver, exacerbation of chronic diseases of the gallbladder and ducts;
- decreased appetite, nausea, dry mouth, constipation, stomach pain, vomiting, diarrhea;
- increased bleeding, nosebleeds, bleeding from the gums and internal organs, a decrease in the content of cellular elements in the blood, anemia;
- flushing of the upper half of the body, fragility of the nail plates, swelling.
We can not say that the drug in question often causes allergies, manifested in the form of Quincke's edema, urticaria, itching and skin rash. Anaphylactic shock is also possible.
Drug overdose
Is an overdose of the drug "Vazonit" possible? Reviews (analogues of this medication are indicated below) say that if the medication is taken incorrectly, overdose symptoms appear quite quickly. The patient has a sharp decrease in blood pressure, as well as nausea, palpitations, shortness of breath, weakness, a feeling of lack of air, redness of half of the body and chills. In rare cases, this condition results in convulsions and loss of consciousness. If the patient has ulcerative lesions of the digestive tract or trophic ulcers, bleeding is possible.
In case of an overdose with the drug in question, you should immediately call an ambulance. Before the doctor arrives, it is necessary to rinse the stomach, as well as drink enterosorbents.
Interaction
The medication in question interacts with many drugs. In particular, it enhances the action of the following drugs:
- suppressing blood coagulability (i.e. indirect and direct anticoagulants);
- lowering blood pressure;
- valproic acid (i.e., drugs with an anticonvulsant effect);
- antibiotic agents belonging to the group of cephalosporins;
- funds for the treatment of diabetes.
It should also be noted that while taking with “Theophylline”, an overdose of the latter often occurs.
When used concomitantly with Cimetidine, the risk of an overdose of Wasonite increases.
Special information
People with severe renal impairment while taking Wazonite should be under regular medical supervision.
In case of hemorrhage in the retina of the eye, treatment should be stopped immediately.
Therapy with the drug in question should be carried out under the constant control of blood pressure. In patients with unstable and low blood pressure, the dosage should be reduced.
In people with diabetes who take hypoglycemic drugs, taking Wasonit in large doses can trigger hypoglycemia.
In the case of the simultaneous use of this drug and anticoagulants, it is necessary to constantly monitor the indicators of blood coagulation.
For patients who have recently undergone surgery, a systematic monitoring of hematocrit and hemoglobin is necessary.
In older people, a dose reduction may be required.
Tobacco reduces the therapeutic efficacy of the drug in question.
During therapy, drinking alcohol is highly discouraged.
Due to the possible occurrence of severe dizziness, patients are advised to exercise special caution when driving vehicles.
Similar drugs
Analogues of drugs are medicines that belong to different groups, but are used to treat the same diseases. The analogue of the drug "Wazonit" is "Xantinol nicotinate, as well as" Thiocol "and" Complamin. These drugs improve peripheral blood circulation, including in the organs of vision and the brain. They also increase the delivery and uptake of O 2 by brain cells and reduce platelet aggregation.
As for the synonyms of the drug in question, they include Pentoxifylline, Flexital, Trental, Agapurin, Latren and others.
The drug "Vazonit": reviews taken
There are a huge number of reviews about the medication in question. Most of them are positive. According to those who took this medicine, Vazonit is ideal for the complex treatment of various diseases associated with impaired peripheral circulation. After taking these pills, the condition of the patients improves markedly. However, experts argue that all vascular diseases can be treated with great difficulty. They require long-term complex therapy under the constant supervision of a doctor.
The positive aspects of this medicine include its relatively low cost. Patients claim that such an effective drug can be purchased for only 250-350 rubles.
Also, there are negative reviews about the medication in question. As a rule, they are associated with side effects that occur while taking it. In addition, if the medicine is not taken correctly, the patient may experience serious overdose symptoms. Therefore, the drug "Vazonit" should be prescribed only by an experienced doctor, taking into account all contraindications and indications.