In the article, we will consider the instructions and reviews for the Cyclodol tool.
It is an anti-Parkinsonian medicine. It is able to have a pronounced H-anticholinergic effect of the central and peripheral type. With a central effect, motor disorders caused by estrapyramidal disorders are reduced or completely eliminated. The drug is able to reduce the tremor that accompanies parkinsonism, to a lesser extent affects bradykinesia and rigidity. It also has an antispasmodic effect associated with direct myotropic effects and anticholinergic activity. The instructions for Cyclodolum are very detailed.
Pharmacological forms
The manufacturer produces the medicine in tablet form. Tablets are packaged in blisters of 25 pieces. Each cardboard box holds 2 blisters.
Structure
According to the instructions for use with Cyclodol, the active component of the drug is trihexyphenidyl hydrochloride. Each tablet contains 2 mg of the main substance.
As auxiliary ingredients are used: magnesium stearate, MCC, lactose monohydrate.
Pharmacological effects
As the instructions indicate, "Cyclodol" refers to a group of anti-Parkinsonian medications.
The mechanism of action of the drug is based on the ability of trihexyphenidyl hydrochloride to act on peripheral m-cholinergic receptors and central H-cholinergic receptors, blocking them.
Pharmacokinetics and pharmacodynamics
In accordance with the instructions for the Cyclodol tablets, the drug is an anticholinergic medication with a central type of exposure. Such agents can disrupt the connection between acetylcholine and dopamine in the central nervous system. As a result, a weakening of cholinergic effects provoked by a lack of dopamine is observed.
Just like other anticholinergic drugs, Cyclodolum acts antispasmodically and reduces tremor. A mild effect on bradykinesia and rigidity is also observed.
Absorption of the active component after oral administration occurs rather quickly. Trihexyphenidyl is able to penetrate the blood-brain barrier. Half elimination takes up to 10 hours. Data on clearance, metabolism, protein binding of blood plasma, distribution are absent.
Indications for use
What else can be found in the instructions for Cyclodolum. The main indication for the use of the drug is parkinsonism (Little, Parkinson's disease), which has any etymology. Also indicated for use in antipsychotic extrapyramidal disorders.
The medication can be used for monotherapy or as an element of complex therapy. Moreover, its use is combined with the use of "Levodopa" (for the treatment of spastic paralysis resulting from damage to the extrapyramidal system).
In some cases, the medicine can improve movement and reduce tone with pyramidal paresis.
Contraindications
According to the instructions, "Cyclodol" should not be used if the patient has the following physiological or pathological conditions:
- The lactation period.
- Pregnancy.
- Obstructive changes in the digestive tract.
- Bowel obstruction, megacolon.
- Atonic constipation, intestinal atony.
- BPH.
- Tachyarrhythmia, atrial fibrillation.
- Glaucoma, in particular a closed-angle type.
- The individual susceptibility of the patient to the active or any auxiliary component that is part of the medication.
It is important to exercise caution when using Cyclodol in patients suffering from cardiovascular diseases, kidney and liver dysfunctions.
Negative impact
According to the instructions for use and reviews of "Cyclodolum", against the background of the use of the drug, some negative effects may develop, among which:
- Rave.
- Hallucinations.
- Tachycardia.
- Constipation
- Urinary retention.
- Increased intraocular pressure. This makes it necessary to regularly check the indicator when using the drug.
- Violation of visual acuity.
- Dizziness.
- Nervousness.
- Drowsiness.
- Dry mouth.
- Skin rash.
If Cyclodol is used for a very long time, the development of such a negative effect as purulent mumps is not ruled out.
If undesirable symptoms occur, you should consult your doctor, however, practice shows that the positive effect of the drug often significantly exceeds its negative effect, and therefore the drug is not canceled. As a rule, the specialist recommends adjusting the dose.
Using
The drug is intended for oral use. Tablets are recommended to be taken with food or before it.
The dosage of the medication should be selected individually, since even the minimum dose can provoke the development of an intoxicating effect and hallucinations. Due to this peculiarity of the drug, patients often experience a trip - a psychedelic state of altered consciousness, which differs from typical awareness and perception. Patients should be aware of this effect of Cyclodol in advance and consult a doctor if it occurs. The degree of tolerance to the drug differs significantly in different patients.
Most often, therapy begins with the use of a minimum daily dosage of 1 mg. The daily dose is divided into 4 doses. To achieve the optimal therapeutic effect, the dosage every 5 days can be increased by 1-2 mg. The maximum single dose in the treatment of adult patients is considered to be 10 mg, daily - 16 mg.
It is important to remember that discontinuation of therapy should occur gradually over several weeks. This is due to the likelihood of developing parkinsonian symptoms, muscle rigidity, a potentially fatal neuroleptic type of malignant syndrome, which is accompanied by hyperpyrexia, changes in mental status, and autonomic dysfunction.
Before starting therapy, specialists should notify patients of the likelihood of addiction. The risk of addiction to the drug increases in patients with mental illness.
The duration of drug therapy is determined by the doctor in each case individually.
Patients over 60 years of age are recommended to use a half-dose of the drug, since the likelihood of hypersensitivity and negative effects in these patients is increased.
If Cyclodolum is used together with Levodopa, the daily dose should not be more than 6 mg.
Overdose
In case of an overdose of Cyclodolum, the following symptoms appear in the patient:
- Cramps.
- Paranoid reactions.
- Ataxia.
- Confusion.
- Incoherence.
- Hallucinations.
- Aggressiveness.
- Excitement.
- Anxiety.
- Disorientation.
- Delirium.
- Disorders of a neuropsychic nature.
- Heart rhythm disturbance.
- Tachycardia.
- Decreased intestinal motility.
- Impaired urination.
- Muscle weakness.
- Dilated pupils.
- Temperature rise.
- Violation of the swallowing reflex.
- Dry mucous membranes and dermis.
- Hyperemia of the face.
In some cases, the patient's condition may worsen until the depression of the central type, coma, death.
According to the instructions for use with the Cyclodol tablets, an overdose can cause dangerous intoxication, so the patient needs immediate help:
- Hemoperfusion and hemodialysis. Such measures have an effect only in those cases when they are carried out in the first hours after an overdose.
- Use of sodium lactate or sodium bicarbonate. These substances can eliminate the complications that appear from the CCC.
- The use of physostigmine. The introduction should be carried out up to 40 minutes, the dosage used is up to 8 mg. This substance allows you to eliminate symptoms such as various blockades, ventricular extrasystoles, tachyarrhythmia, extrapyramidal disorders, coma, delirium.
Interaction with other medicines
The likelihood of developing negative effects increases with the parallel use of Cyclodol with phenothiazine derivatives and tricyclic antidepressants.
When used with sublingual nitrates, their effectiveness is weakened.
Use in the treatment of children
The use of Cyclodol in the treatment of children 5-17 years old is allowed, but only for the purpose of extrapyramidal-type dystonia therapy.
The dosage should be selected strictly individually, and the maximum dose per day should not exceed 40 mg.
The use in the treatment of newborn children is unacceptable.
Analogs
In the instructions for use, analogues of Cyclodol are not indicated.
If necessary, the medication can be replaced with one of the similar drugs, however, it should be remembered that Cyclodol and its analogues are potent drugs, have a number of specific contraindications, and can provoke the development of negative effects. Therefore, replacement should be done only after consulting a doctor.
The most popular counterparts are: "Yumex", "Eldepril", "Tropatsin", "Tremonorm", "Tasmar", "Stalevo", "Sinemet", "Selegilin", "Segan", "Requip Modutab", "Pronoran", “PC Merz”, “Permax”, “Parkon”, “Pantocalcin”, “Pantogam”, “Niar”, “Nakom”. Mirapeks, Midantan, Mendileks, Madopar, Credanil, Cognitive, Isicom, Zimox, Duelin, Akineton, Azilekt.
We will not consider the instructions for the analogues of Cyclodol in detail.
Cost
The average cost of Cyclodol in Russian pharmacies is 100 rubles per package, containing 50 tablets. It depends on the region and the pharmacy network.
Reviews
Reviews about "Cyclodol" are very mixed and the question of the appropriateness of using this drug is acute. On the one hand, when using the medication, vision, cognitive functions, the urinary system suffer greatly, addiction develops. In addition, Cyclodolum provokes a severe withdrawal syndrome.
However, there are examples where the dosage of the drug was chosen correctly, and patients have been taking the drug for decades without any serious consequences.
The response of the patient depends entirely on the professionalism of the attending physician, the severity of the disease and its nature, as well as on the individual susceptibility of the patient to the active component.
It is important to remember that the drug should be prescribed exclusively by a doctor and strictly according to indications.
We reviewed the Cyclodol preparation, instructions for use, reviews and analogues.