Throughout his whole life, a person often encounters pain. They can haunt the body for a very long time. This can be either a temporary headache or a constant pain in connection with certain diseases. There are times when conventional analgesics do not help, and then the drug Nimesulide comes to the rescue, which is a powerful antipyretic and analgesic.
Composition and form of release
This drug is synthetic. The active substance is nimesulide. The drug has 4 forms of release. First of all, these are tablets, which include 100 mg of the active substance. Tablets are in blisters of 10 pieces, in a cardboard package there may be 1, 2 or 3 blisters. Nimesulide is also available in powder form from which a suspension can be made. One sachet contains 100 mg of the active substance. In a cardboard package can be 30, 15 or 9 sachets. In addition, this drug has the form of a ready-made suspension, a volume of 5 ml, which contains 0.05 mg of nimesulide. Another form of release of the drug "Nimesulide" is a gel, which has a volume of 30 g.
pharmachologic effect
The drug "Nimesulide" is an analgesic, anti-inflammatory, antiplatelet and antipyretic.
Indications for use
Do not forget that this medicine does not affect the progression of the disease, it is intended for symptomatic treatment and reduces or relieves pain only for the duration of its use. The medicine "Nimesulide" is used for toothaches and headaches, as well as for certain diseases of muscles and joints. Such diseases are osteoarthritis, rheumatoid arthritis, arthralgia, myalgia, tendonitis, bursitis, algomenorrhea and pain in the postoperative period. Also, various infectious and gynecological diseases are an indication for use. This drug is also used for fever.
Contraindications
A fairly large number of contraindications have both powder and Nimesulide tablets. Instructions for use determine exactly these:
- active bleeding of the gastrointestinal tract;
- erosion or ulcers on the mucous membrane of the stomach or on the duodenum;
- cerebrovascular bleeding;
- hemophilia or other causes of blood clotting;
- Any inflammatory bowel disease with exacerbation, such as ulcerative colitis or Crohn's disease.
In addition, contraindications are:
- active liver disease or liver failure;
- heart failure;
- bronchial asthma;
- recurrent polyposis;
- progressive kidney disease or renal failure;
- hypersensitivity to any components of the drug;
- alcoholism and drug addiction.
It is also forbidden for children under the age of 12, women who are expecting a baby or breastfeeding, to take Nimesulide tablets. Instructions for use show that this drug should be used with caution in patients who have cerebrovascular disease, dyslipidemia, heart failure, and diabetes mellitus. Patients with bad habits and elderly people should also take the medicine with caution.
Drug use
Nimesulide in the form of tablets, suspensions or powders is taken orally. Nimesulide gel is applied to the skin with pain. The use of the drug is possible only in patients over 12 years old. Tablets and suspension are used 2 times a day (100 mg of active ingredient). The maximum dose of the drug is 400 mg. When using the preparation in the form of a gel, it is necessary to apply it on the affected area of the body (not more than 3 cm) and rub it with light massaging movements. The gel can not be applied under a bandage.
When preparing a suspension of Nimesulide, the powder must be dissolved in 100-150 ml of water. Patients who have renal failure should reduce the daily dose, it should be 100 mg of nimesulide. Elderly people do not need a dose reduction. It is necessary to comply with some rules when using the drug "Nimesulide." Not everyone knows what this is, therefore, in order not to cause adverse reactions, it is necessary to drink this medicine with a large volume of water, and also use the maximum dose per day for a very short time. With a minimal dose of the drug, the course of treatment can be continued for about 2 weeks. If long-term treatment is required, it is necessary to be constantly monitored by a doctor.
Adverse reactions
When taking this drug, a side effect may be observed. It can manifest itself as an allergic or other similar reactions. Side effects can cause both gel and powder, and Nimesulide tablets. The instruction determines the possibility of such skin reactions:
- the appearance of itching and rash on the skin;
- increased sweating;
- dermatitis;
- erythema;
- swelling of the face;
- urticaria.
Possible reactions of the nervous system:
- nervousness;
- a feeling of fear;
- dizziness and headache;
- drowsiness and nightmares;
- encephalopathy.
Regarding the urinary system:
- dysuria;
- swelling;
- hematuria;
- renal failure;
- urinary retention;
- oliguria;
- hyperkalemia;
- Instructial jade.
Side effects regarding the digestive system may also occur:
- vomiting and nausea;
diarrhea or constipation;
- abdominal pain, gastritis;
- flatulence;
- stomatitis;
- stomach ulcer;
- gastric bleeding.
These are the undesirable reactions that Nimesulide can provoke (tablets). The instruction shows that regarding the hematopoietic system, there can also be a side effect:
- thrombocytopenia;
- anemia;
- pancytopenia;
- eosinophilia.
Regarding the respiratory system, reactions such as:
- shortness of breath;
- bronchospasm;
- asthma.
General weakness, tachycardia, hypertension, blurred vision, and hypothermia are also possible.
Overdose
In case of an overdose, side effects may increase. To bring the body in order after an overdose of Nimesulide, it is necessary to rinse the stomach and take activated charcoal. In this case, it is necessary to constantly monitor the function of the kidneys and liver.
Interaction with other drugs
Do not use Nimesulide tablets with inhibitors and corticosteroids; use in this case can lead to the development of gastric bleeding. Taking this drug with a diuretic is not recommended, since renal hemodynamics can be impaired. Nimesulide helps reduce the bioavailability of furosemide. It also has the ability to replace furosemide and salicylic acid in plasma proteins. It is forbidden to use this medicine with alcoholic beverages.
Special instructions
If improvement does not occur, you must stop using the drug "Nimesulide." What is it and why the medicine does not work, the doctor must explain and prescribe another remedy. It should be a very short time to take the maximum daily dose to avoid side effects. The use of the drug should be discontinued if, against the background of its administration, a temperature increase is observed or flu-like symptoms develop.
The development of side effects most often occurs in elderly people, therefore , it is necessary to monitor the patient's condition during treatment with the Nimesulide drug. Analogs of this drug should also be taken with caution in older patients.
Nimesulide has a negative effect on the fertility of women. Therefore, you should not take it during pregnancy planning. This drug has an effect on the central nervous system, so you should not drive a car. Activities that require increased concentration of attention should be avoided.
Drug storage
Nimesulide should be stored in a dark and dry place. The temperature should not exceed 24 degrees. Do not use the drug after the expiration date, which is 48 months.
"Nimesulide." Analogs
This drug contains the active substance nimesulide, also this substance is found in all substitutes for this drug. The need for an analogue can arise for various reasons, for example, some substitutes contain a lower dose of nimesulide, and some have many additional substances that give the drug a more pleasant taste and smell. Most often, pharmacies offer such drugs instead of Nimesulide: Nimesulide Maxfarma, Nise, Nimesil, Nimika, Nimulide, Mesulide, Nemuleks, Kokstral, Novolid, Prolide ”,“ Florida ”,“ Aulin ”,“ Aponil ”,“ Ameolin ”. Many of these drugs are available in the form of tablets and powder, as well as in the form of a gel for rubbing into the skin.
Reviews about the drug
In general, reviews about this drug are only positive. In addition, the price of it is quite affordable. Many patients believe that Nimesulide helps to cope with pain better. What it is, every adult knows who has had to deal with severe pain or fever. Many patients say that the drug practically does not cause side effects, some think quite differently, indicating that after taking the medicine it tends to sleep. The instruction warns about this and advises not to get behind the wheel of a car. Patients also highlight the fact that Nimesulide acts quickly and gently with respect to its analogues. But in any case, you should not take the medicine for a very long time, and if there is a need, you should consult a doctor and, if possible, replace it with a weaker drug, which includes nimesulide. What it is? The main active ingredient of many painkillers.