The drug has an effect that is manifested by the acceleration of metabolic processes in the sensorineous organs and in the myocardium. Before starting therapy, you need to find out what the drug "Trimetazidine-Biocom MV" is. Instructions for use, the composition of the medication is useful information, which is worth reading.
Form of release of the drug, its components
The drug belongs to modified release agents, is available in the form of tablets in a shell, and is made on the basis of trimetazidine dihydrochloride. The blister contains 10 tablets, in a pack they can be from 1 to 6. One tablet contains 35 mg of the main component. The composition is supplemented with magnesium stearate, povidone, aerosil, hypromellose and calcium hydrogen phosphate dihydrate.
Titanium dioxide, macrogol belong to the components of the shell of the tablets "Trimetazidine-Biocom MV". The instructions for use report that in addition to these substances, the shell consists of hypromellose and red iron oxide.
pharmachologic effect
An antihypoxic drug allows you to return normal metabolism to cells in which negative changes have occurred due to the development of a pathological condition (ischemia, hypoxia). Tablets eliminate the reduction in the amount of ATP inside the cells, contribute to the improvement of the state of ionic membrane channels, transmembrane movement of sodium and potassium ions. It is possible to maintain cell homeostasis during the treatment period using the medication “Trimetazidine-Biocom MV”. Instructions for use informs that the drug reduces the rate at which the oxidative process of fatty acids occurs, due to which glucose is more actively oxidized, and the myocardium is protected from ischemia. The effect of the drug is based on switching the oxidative process from fatty acids to glucose.
The drug, supporting the normal course of metabolic processes, has a positive effect on the neurosensory organs and heart, and reduces the severity of disturbances in the ion transmembrane flow during the development of ischemia. By acting on the heart tissue, the drug helps to reduce indicators such as migration, infiltration of polynuclear neutrophils. Regarding the action of the drug "Trimetazidine-Biocom MV", the instructions for use include data that reflect the positive effect on the myocardium damaged due to ischemia. The drug has absolutely no effect on hemodynamics.
Pharmacokinetics
Absorption occurs almost completely and quickly. Communication with plasma proteins is negligible (16%), the bioavailability indicator is 90%. From the moment of taking the pill to the moment when the level of the active substance in the body becomes maximum, it takes about two hours. It is known that the drug easily passes through histohematological barriers. The elimination half-life takes about five hours. The medicine is removed from the body by the kidneys, most of it does not change its shape.
Indications
The "Trimetazidine-Biocom MV" (tablets) instruction allows you to use it for the implementation of long-term treatment of coronary artery disease. Its purpose is shown in the following cases:
- the need for preventive measures when angina attacks occur;
- dizziness, the presence of which is associated with vascular lesions;
- cochleo-vestibular disorders of ischemic nature (hearing impairment);
- chorioretinal vascular pathologies accompanied by ischemia.
Prevention of angina pectoris can be performed using a single drug or by implementing complex therapy.
Contraindications
Regarding cases when the administration of the drug "Trimetazidine-Biocom MV" is undesirable, the instructions for use, the reviews contain data showing the impossibility of treatment with the drug in such conditions:
- excessive sensitivity to the main component and other ingredients of the product;
- breastfeeding;
- the period of bearing a child.
Since the safety of using the drug in childhood (less than 18 years) and the effectiveness of treatment with its use have not been established, this drug is not prescribed for such patients.
The medicine is contraindicated in cases of severe impaired liver function and kidney failure, in which an indicator such as creatinine clearance is significantly reduced (15 ml / min or less). Not only indications and contraindications determine the possibility of treatment with the drug "Trimetazidine-Biocom MV". Cost also has a certain value when choosing a medication for the implementation of therapy. We will talk about her a little later.
Drug treatment
The size of a single dose is determined by the doctor (usually not less than 40 mg, but not more than 60). A day requires 2-3 doses. The duration of therapy is set separately for different cases.
Side effects
Before proceeding with therapy, one must familiarize oneself with possible undesirable reactions of the body as a result of taking Trimetazidine-Biocom MV tablets. Instructions for the use of the drug on which the treatment is based refers to side effects an allergy, manifested both by itching and a skin rash, other reactions that are not the norm for the body. During treatment, in very rare cases, some patients experience nausea, vomiting, and gastralgia.
Cases of severe overdose have not been recorded, and the possibility of their occurrence is unlikely. As a result of exceeding the recommended dose, facial hyperemia, hypotension can be observed.
special instructions
The treatment does not interfere with the ability to drive a car and does not interfere with activities that require quick physical and psychomotor reactions.
Tablets are not suitable for eliminating angina attacks and can be used only for prophylactic purposes by patients who suffer from such attacks.
Against the background of treatment in patients with coronary heart disease, there is a decrease in the daily need for nitrates.
The cost of the drug, analogues, reviews
Instructions for use should be studied before starting treatment with Trimetazidine. The price is also important information and is taken into account when choosing a drug for the treatment (prevention) of heart problems (CHD). The approximate cost of the drug is 100-165 rubles. for 30 tablets and 189-208 rubles. for 60 tablets.
As an analogue, you can use Preductal, Antisten or Trimet. Perhaps treatment with drugs "Medarum", "Rimekor." The doctor can replace the medication by prescribing Precard, Angiosil, and Trmitard MV. There is the possibility of treatment with "Triducard", "Predizin", "Trimectal" or "Metagard". Judging by the reviews, the most popular analogue is Preductal, this drug is effective, but costs more than Trimetazidine. Instructions for use, the price shows that it is beneficial to be treated with the drug, reviews confirm the effectiveness of such therapy.
In the reviews about the medication, it is reported that the drug eliminates heart pain well, it performs its task perfectly. As a result of taking the medicine, according to patients and doctors, there are positive changes, for example, the body of people who have undergone therapy, better perceives physical activity. Many people claim that after several days of treatment, they have shortness of breath, tachycardia passes, and blood pressure indicators return to normal. Usually, improvements are noted on the fourth day of treatment, which is based on the use of Trimetazidine-Biocom MV. Instructions for use, the price shows that the medication is not only affordable, but also effective, in addition, it has a minimum number of possible unwanted reactions that usually do not develop. The appearance of side effects is observed in rare cases.
So, we have provided comprehensive information about the drug "Trimetazidine-Biocom MV". Analogs, price, instructions, reviews about the medicine are now known to you. The drug should be prescribed by a specialist and used in the dosage prescribed by him. The need for a replacement drug is also determined by the doctor based on many factors. Compliance with all recommendations allows you to make treatment the most effective without harming your health.