"Rhythmorm" - a drug with antiarrhythmic action. When using the medication, sodium channels are blocked. The drug has a direct membrane stabilizing effect, has an effect on myocardiocytes. Before starting treatment, the properties of the Ritmonorm drug are studied, instructions for use, reviews, analogues. Consider this information in more detail.
Components of the drug, release form
The drug is made in the form of tablets in a shell. The active substance used in the composition is propafenone hydrochloride. Each tablet has 150 mg of active ingredient. The tablets also contain adjuvants such as titanium dioxide, microcrystalline cellulose, starch derived from corn, magnesium stearate, hydroxypropyl methyl cellulose 2910 and croscarmellose sodium. Other additional components include macrogol 6000 and macrogol 400, purified water.
Drug action
The maximum possible speed at which depolarization of the action potential can occur (phase 0) decreases, in the same way, the drug affects the amplitude in the fibers (applies to both the fibers of the ventricles contractile and Purkinje), inhibits the automatic implementation. Purkinje fibers are carried out more slowly, while the time spent on the atria and sinoatrial node is prolonged. "Rhythmorm", analogues of the drug do not affect the corrected time necessary to normalize the function that the sinus node has during the period of electrical stimulation, or this effect is minimal. The electrophysiological effects are better manifested in the myocardium with ischemia, the effects of m-choline and beta-adrenergic blocking are weak.
The drug "Rhythmorm", analogues of the drug have in their composition substances that provide an inotropic negative effect, which is usually present when the ejection fraction of the left ventricle decreases.
The activity of the drug is characterized as a local anesthetic, there is a similarity with the activity of Procain. Rhythmorm begins to act 60 minutes after internal use. The maximum effectiveness of the drug is detected on average 2.5 hours after it enters the body, the duration of the effect remains on average for 10 hours.
With internal administration, absorption in the digestive tract occurs almost completely. Metabolism is carried out in the liver. The drug is partially excreted in about 5 hours, is removed from the body by the kidneys in the form of metabolites and by the liver, and is present in the composition of bile.
Indications
"Rhythmorm", analogues of the drug are prescribed for the treatment of the same diseases. Tablets are used in the following cases:
- ventricular arrhythmia;
- supraventricular tachyarrhythmia is paroxysmal.
Contraindications
Contraindications are as follows:
- hypersensitivity to the components of the drug;
- severe bradycardia;
- a syndrome in which weak sinus node is noted;
- heart failure of a chronic nature;
- myasthenia gravis;
- marked decrease in blood pressure;
- bronchospasm;
- the period of bearing a child, feeding him with breast milk;
- obstructive diseases in which the lungs are affected, proceeding severely and chronically;
- children's age (less than 18 years);
- severe problems with intraventricular, atrioventricular and sinoatrial conduction;
- severe violations in the work of the kidneys and liver;
- cardiogenic shock with the exception of arrhythmic shock;
- hyper- or hypokalemia.
"Rhythmorm", analogues of the drug is prohibited to use for the first three months if a person has suffered myocardial infarction or has a reduced left ventricular ejection fraction. The exception is patients who have been diagnosed with ventricular arrhythmia, a condition that threatens not only health but also life.
In some conditions, caution is needed, during the treatment period, careful medical supervision is necessary.
Drug use
Tablets are drunk after eating, swallowing whole. The duration of the course of treatment is determined by the doctor, taking into account many factors. The same applies to the dose of Rhythmorm. Analogues the price of such drugs (lower) does not make bad and ineffective means. These drugs also perform the task well, but their effect may be slightly different.
At the initial stage, it is recommended to be treated in a hospital. Adult patients weighing more than 70 kg are prescribed therapy based on three doses of the drug. Typically, the dose intended for use at a time is 150 mg.
In cases where the QT interval or the QRS complex is increased by 20% or more compared with those that were established before the start of therapy, the dose is reduced. There is another option - a temporary cessation of treatment.
An increase in the dose of the drug can be made, observing an interval of three days. At the same time, it can be increased to a maximum of 300 mg twice a day (sometimes thrice).
Patients in old age with a body weight not exceeding 70 kg are prescribed reduced doses of the Rhythmorm drug (tablets). Reviews, description, analogues of the drug allow you to evaluate the capabilities of the medication and, if necessary, replace it.
When patients with liver problems are treated with the drug, a dose reduced by 20-30% (since cumulation may occur) is used, and a dose reduced by 50% with kidney problems.
Side effects
The patient can be detected negative changes in the cardiovascular and nervous systems, gastrointestinal tract. Possible violations in the reproductive system and a change in laboratory parameters. Among other side effects are skin rashes (hemorrhagic), arthralgia. Bronchospasm, general weakness may occur.
special instructions
If necessary, you can stop taking Rhythmonorm. Analogs and substitutes for the drug must be selected by a doctor. Cancellation of "Rhythmorm" is possible after receiving expert advice.
Treatment requires regular monitoring of electrolyte balance and ECG. From time to time, other indicators should be monitored.
In the treatment of patients who have an implanted pacemaker, attention should be paid to changing the threshold of pacing, defibrillation. Their increase leads to the obligatory correction of the parameters with which the pacemaker works.
The drug should be taken with caution to those who drive vehicles or engage in activities that require quick reactions and attention.
For those who plan to be treated with Rhythmonorm, the instructions, the price in pharmacies, analogues can be interesting. Below are the cost of the drug, its substitutes, reviews of people who were treated by Rhythmorm and shared their opinion.
Analogs, the cost of the drug, reviews
The price of the drug is approximately 545-700 rubles. for packing tablets (50 pcs.). Among the well-known analogues are Profenan, Propastad, Prolekofen. Often, doctors prescribe a substitute for "Propafenone OF 300" or replace the drug "Propafenone OF 150". If you need to choose an analog, you can give preference to "Propaphenone" or "Propanorm".
Before treatment with Rhythmonorm medication, analogues, price, instructions for use are not the only things that need to be studied. Useful to read reviews. As the reviews show, the drug can help someone, but not at all bring any result to someone. There are people who take the medicine when their health worsens, there are those who are treated by him on the advice of a doctor. If the expected result is missing, there is a need for an additional examination in order to adjust the established treatment regimen.