Few people know, but psychoses, neurosises and depressive states are amenable to medical treatment. The main thing is to turn to an experienced specialist in time and strictly follow all his recommendations.
As a rule, in such conditions, patients are prescribed antipsychotic drugs or the so-called antipsychotics. They significantly reduce the symptoms of psychotic disorders, returning the patient a clean mind and clear thinking.
Most often, with the above diseases, a medication such as Truxal is prescribed. Instructions, reviews, adverse reactions and contraindications for this drug will be described below.
Form, description, packaging and composition
The Truxal medication (reviews of doctors about it will be described at the end of the article) is available in the form of dark brown round and biconvex tablets coated with a film coating.
The drug in question contains such an active ingredient as chlorprothixene hydrochloride. It also includes additional components in the form of corn starch, copovidone, lactose monohydrate, glycerol, microcrystalline cellulose, talc, croscarmellose sodium and magnesium stearate.
As for the film membrane, it consists of hypromellose, macrogol 400, red iron oxide, black iron oxide and titanium dioxide.
What packaging do Truxal tablets go on sale in? Customer reviews report that on the shelves of pharmacies this medication can be found in cardboard packs that contain plastic containers.
Drug action
What is Truxal Medication? Reviews of experts report that this is a very effective drug. It is an antipsychotic drug (i.e. antipsychotic) and is a derivative of thioxanthene.
This medication is able to have a moderate antidepressant, pronounced sedative, as well as antipsychotic effect.
The last property of the drug is due to its ability to block dopamine receptors. With this action of the medication, its analgesic and antiemetic effects are also associated.
According to the attached instructions, Truxal, reviews of which are ambiguous, is able to block not only alpha-1-adrenergic receptors and serotonin 5-HT2 receptors, but histamine H1 receptors. This causes its antihistamine, hypotensive and adrenergic blocking effect.
Drug kinetics
Is the Truxal medication absorbed? Customer reviews will not give an answer to the question. For it you will have to turn to the instructions or an experienced specialist. According to them, after taking the medication inside, chlorprotixen is fairly quickly absorbed from the digestive tract.
In the blood, the highest concentration of the active substance is observed after 120 minutes. The bioavailability of the drug is 12%.
It should be noted that chlorprotixene quite easily penetrates the placental barrier, and also in small quantities it is excreted along with milk.
The half-life of this agent is 16 hours. The resulting metabolites do not have antipsychotic activity. They are excreted along with feces and urine.
Indications
In what conditions are Truxal tablets indicated? The reviews of doctors say that the effectiveness of this medication is most pronounced with the following deviations:
- withdrawal syndrome in addiction and chronic alcoholism;
- psychoses, including manic states, schizophrenia, psychomotor agitation, agitation and anxiety;
- impaired behavior in children;
- hyperactivity, agitation, irritability, confusion in the elderly;
- insomnia;
- depressive states, psychosomatic disorders and neurosis;
- pain syndrome (in combination with analgesics).
Contraindications
According to the instructions, taking Truxal antipsychotic is contraindicated in:
- pheochromocytoma;
- coma ;
- CNS depression of various origins (including alcohol, opioid analgesics and barbiturates);
- diseases of the blood;
- breastfeeding;
- vascular collapse;
- pregnancy
- hypersensitivity to the ingredients of the drug.
Pills "Truxal": instructions for use
Reviews of experts say that this medication should be used only as directed by an experienced doctor. Otherwise, its uncontrolled intake can contribute to the development of many undesirable reactions.
The dosage of this drug depends on the type of disease.
For psychoses, as well as schizophrenia and manic conditions, at the very beginning of therapy, the medication is prescribed in a dosage of 50-100 mg per day. In the future, the amount of the drug is increased to 300 mg per day (sometimes up to 1200 mg). The specified dose is divided into 3 doses.
In the treatment of withdrawal symptoms with drug addiction and chronic alcoholism, the daily dose of the drug should be 500 mg in three divided doses. The course of therapy is one week.
In the presence of irritability, agitation, hyperactivity or confusion, the elderly are prescribed medication in the amount of 15-90 mg per day (in three doses).
Children are given a dose of 0.5-2 mg per kg of weight to correct violations in behavior.
In depression, which are combined with stress and anxiety, Truxal tablets can be used both as monotherapy and as an additional treatment for antidepressants.
For psychosomatic disorders and neurosis, accompanied by depressive disorders and anxiety, the drug is recommended to be used in a dose of up to 90 mg per day (in three doses).
Due to the fact that this drug is not addictive or drug addiction, it can be used for a long time.
With insomnia, tablets are prescribed 20-30 mg in the evening and one hour before bedtime.
The drug "Truxal": reviews, side effects
Like any antipsychotics, the medication in question quite often causes side effects :
- drowsiness, extrapyramidal symptoms, dizziness, accommodation disturbances;
- tachycardia, orthostatic hypotension ;
- dry mouth, cholestatic jaundice, constipation;
- dysmenorrhea, weakening potency, galactorrhea;
- weight gain, increased sweating, increased appetite;
- hemolytic anemia, transient benign leukopenia;
- skin rashes.
Reviews about this tool are more positive. Quite often, mothers of children with behavioral disorders speak about him. They claim that this drug is ineffective.
As for doctors, their responses are infrequent. From those that are available, we can safely conclude that this drug in each case shows a different result.