"Antisten" (international nonproprietary name - trimetazidine) - has an antihypoxic effect. Eliminates hypoxia by restoring normal energy metabolism in cells, equalizing the amount of oxygen supplied and released. It affects the neurons and cardiomyocytes of the brain, providing them with the necessary substances.
It blocks the increased secretion of fatty acids, which are the main causes of impaired cellular metabolism. It relaxes the heart muscle, thereby stabilizing myocardial contractions. Strengthens cell membranes, preventing the accumulation of potassium, calcium and sodium ions in them.
Pharmacokinetics
The active substance (trimetazidine) is rapidly and almost completely absorbed in the digestive system. The digestibility of "Antisten" is almost 90%. Achieving maximum blood levels is carried out within 2 hours. Easily overcomes the barriers between blood and tissues. Binding to plasma proteins reaches 16%. It is excreted through the kidneys (almost 60% - in the initial state). The time for complete elimination is approximately 14 hours. In persons over 65 years of age taking the drug, the elimination period is extended and reaches 24 hours.
Release form and composition
The drug "Antisten MV" 35 mg No. 60 (analogues can be found in the same dosage) is available in the form of biconvex, rounded tablets. Which are packaged in special polymer containers. Each Antisten tablet consists of 2 layers: the inner or nucleolus has a white or yellowish tint, there is a red shell on the outside. One tablet of Antisten contains 20 mg of the main substance, trimetazidine dihydrochloride.
The composition also includes auxiliary components, which are magnesium stearate, hypromellose, triacetin, yellow and red iron oxide, microcrystalline cellulose.
Instruction "Antisten"
Consume orally in a daily dosage of 40-60 mg, divided into 2-3 doses. Depending on the type and severity of the disease, in each case a special course of treatment is prescribed.
Application
"Antisten" is used for:
- Long-term therapy of cardiac ischemia: prevention of possible angina attacks (as an independent drug or one of the components in combination treatment).
- Therapy for damage to the vestibular system and organ of hearing (including dizziness, tinnitus, hearing damage).
- Vascular impairment of vision.
Side effects
A large number of patients using this drug have a high tolerance.
Rarely, but there are some undesirable effects:
- from the gastrointestinal tract - dyspeptic disorders, pain in the abdomen, nausea, vomiting, diarrhea;
- damage to the nervous system, manifested by cranialgia, discoordination of movements, symptoms of extrapyramidal insufficiency, which cease when the Antisten is abandoned;
- on the part of the cardiovascular - lowering pressure, a feeling of palpitations, the occurrence of arrhythmias;
- platelet count decreases in blood, agranulocytosis occurs;
- dermatological consequences may occur in the form of an allergic rash and itching of the skin.
In rare cases, toxic hepatitis occurs.
The use of "Antisten" is prohibited:
- in pregnant women;
- during breastfeeding;
- in children and adolescents;
- with impaired renal function;
- with increased sensitivity or individual intolerance to some components of the drug.
Use in pregnant women and during breastfeeding
Tests conducted on animals showed that Antisten cannot have a teratogenic effect on the fetus. However, due to insufficient information on safe treatment with Antisten during pregnancy, the likelihood of various deviations in the development of the fetus cannot be completely ruled out. That is why in pregnant women, when prescribing treatment, this medicine is not used.
It is also not determined whether Antisten passes into breast milk. If the appointment of "Antisten" is necessary, then breast-feeding should be stopped.
Not approved for use in children.
Interaction with other drugs
No effects of the interaction of "Antisten" were found with its simultaneous administration with other drugs.
At the moment, there is no indication of an overdose of the drug "Antisten" instructions for use. Analogues of the drug are widely used.
special instructions
"Antisten" 35 mg (including analogues) is prescribed to prevent a possible attack of angina pectoris, but it can not be used for relief. The appointment of "Antisten" for the initial stage in the treatment of heart attack or unstable angina is not recommended.
The simultaneous use of alcoholic beverages and treatment with Antisten is not allowed, since the active substances have the opposite nature of the effect (ethanol and trimetazidine). If one or several doses of the drug is missed, it is not allowed to use it in an increased dosage during the next use.
"Antisten" has no effect on the reaction rate and does not cause drowsiness, therefore, it can be used when driving vehicles.
The shelf life of Antisten is 36 months from the date of manufacture. Keep it in a dry, cool and out of reach of children. Protect from sunlight. Do not use after the expiration date, as this can significantly reduce the effectiveness or cause the appearance of unwanted symptoms.
How to replace the drug?
On sale are available to the drug "Antisten" analogues. Reviews about them are very positive. Perhaps the use of drugs similar to "Antisten" by the mechanism of action:
- hawthorn flowers;
- "Vasomaga";
- "Histochrome";
- Dinaton;
- "Dibikora";
- "Doppelgerts Cardiovital";
- "Esaphosphine Lyophilisate";
- Idrinol
- camphor preparations;
- "Cardionate";
- Kudesana;
- Mexicora;
- "Meldonia";
- Mildronate
- sodium adenosine triphosphate;
- neoton lyophilisate;
- Orokamaga;
- Riboxin;
- "Serotonin";
- Taufon;
- "Ubinone";
- Firazira or Phosphaden.
Antisten: Russian analogues
- "Angry retard." It is more affordable, but as strong as Antisten (cheap analogues can be bought at any pharmacy). It has a high incidence of side effects.
- Vero-trimetazidine is a cheaper drug.
- "Deprenorm MV" - when it is prescribed, there are more side effects, it is more expensive.
- "Medarum" - there are practically no side effects, but the drug is several times more expensive.
- "Rimekor" - has a longer action, a greater frequency of side effects, cheaper.
- "Carditrim" - causes more frequent side effects, an expensive analogue.
- "Triducard" and "Trimectal" are less effective, which is why they are not recommended for use as substitutes for the drug "Antisten".
Import analogs and substitutes
- "Metagard" - with the appointment more often side effects occur, it is an expensive analog
- "Predizin" - side effects occur more often.
- "Trimetazide" - has fewer side effects.
- Precard is a cheap but less effective counterpart.
- Trimetazidine-Teva is a more expensive drug.
Reviews
"Antisten" (analogues also) is quite often used in modern therapy, therefore, reviews about it are very diverse. The overwhelming majority of patients speak of Antisten as a very effective remedy.
The medicine has helped many, patients note that their general condition has improved, sleep has recovered, pressure has returned to normal. Life potential has increased. The drug removes dizziness and noise in the head. In case of vascular visual impairment, Antisten helps restore the function of the retina.
Only in a small number of cases, when using the drug "Antisten" (including analogues), during the treatment of coronary heart disease, low efficiency was noted. Probably, this could occur as a result of the progression of the disease or in the presence of chronic heart disease.
Of course, everyone should be aware that the use of one "Antisten" will not affect and will not relieve disturbances in the functioning of the cardiovascular or nervous systems. This drug acts only as an auxiliary and supportive tool. Sometimes even doctors have doubts about the need to use drugs of a similar nature, as often patients independently refuse them, removing them from the treatment regimen. However, when patients comply with all the appointments of the attending physicians, the result and further prognosis in most cases are quite favorable.
Thus, if you use "Antisten" (including analogues) as the main drug in the fight against cardiac ischemia, you can get an insignificant result. However, greater effectiveness of the drug is achieved if applied in combination therapy as a means to improve cellular metabolism. Patients study its effects, compare with similar drugs, find out the possibility of their replacement and try to determine which one is more effective and safer?
Before using the medication, you must consult a doctor. But for familiarization in each package there is an instruction for use for the Antisten preparation. Reviews, analogues we have been considered in detail.