Anabolic drugs - a group of drugs whose main mechanism of action is aimed at increasing the energy supply of cells, accelerating their growth and differentiation, weight gain and accelerating metabolic processes. One of the representatives of this group of drugs is Riboxin.
Pharmacological characteristics of the drug
The drug "Riboxin" is an anabolic drug, the main effect of which is aimed at increasing the resistance of tissues to hypoxia. Being a precursor to adenosine triphosphoric acid, Riboxin is involved in the breakdown of glucose inside the cell and, accordingly, the formation of adenosine triphosphoric acid, which is the main cellular energy substrate. In view of this effect, Riboxin has an antihypoxic effect in conditions of reduced ATP content.
The anabolic effect of “Riboxin” is manifested by an increase in metabolic processes involving pyruvic acid and activation of xanthine dehydrogenase. Due to these effects, Riboxin has a positive effect on the flow of metabolic effects within the cell, contributing to their energy supply for normal functioning.
When exposed to the myocardium, Riboxin optimizes the functioning of myocardiocytes, contributing to a more complete relaxation of them (increasing the phosphorylation of actin-myosin bonds), and also activates regenerative processes in the myocardium.
From the point of view of pharmacokinetic processes, Riboxin perfectly enters the systemic circulation in the lumen of the gastrointestinal tract. With the parenteral route of administration (intravenously), “Riboxin” is rapidly distributed throughout the tissues with the passage of subsequent stages of metabolism in the liver cells, where it is completely cleaved. Excretion of metabolites and non-metabolized molecules of the drug occurs mainly with urine, and an insignificant part is excreted with feces and bile.
Indications for use
The drug "Riboxin" is indicated for the treatment of coronary heart disease, including for the treatment of post-infarction conditions. The drug has a good therapeutic effect in the treatment of rhythm and conduction disturbances, overdose of cardiac glycosides, treatment of morphological defects of the heart muscle arising from increased physical activity or after infectious and inflammatory diseases.
"Riboxin" is indicated in the treatment of diseases of the hepatobiliary system, for the prevention of diseases of the blood system when receiving high doses of ionizing radiation. In ophthalmic practice, the use of "Riboxin" is advisable for open-angle glaucoma.
"Riboxin": instructions for use, analogues
When using the tablet form of the drug, you should adhere to such recommendations. For adults, the daily dose of the drug can be from 0.6 to 2.4 grams. As a rule, the dosage is selected individually, and the daily dose is divided into several doses throughout the day. The tablet form should be prescribed with the minimum dosage, and only if the minimum dose is normally tolerated by the patient, it is increased after 2-3 days. The duration of therapy should be from 1 to 3 months.
With parenteral administration, a 2% solution of Riboxin is diluted with 250 ml of physiological solution of sodium chloride or glucose. The infusion is carried out slowly, at a speed of 40-60 drops per minute.
Among analogues with a similar dosage and method of application, it is necessary to note "Inosine" and "Ribosin", which will be discussed below.
Contraindications
Contraindications to the appointment are hypersensitivity to one or more components of the drug, gout and increased uric acid in the blood plasma. With extreme caution, it is necessary to prescribe "Riboxin" and the analogue of "Riboxin" "Inosine" in patients with renal excretory function insufficiency.
Side effects
Usually the drug is well tolerated. Among people who have been hypersensitive to the drug, allergies from the skin can be observed. From the side of the cardiovascular system, a sensation of palpitations, an increase in blood pressure, and general weakness may occur.
If the patient taking Riboxin has the above side effects, you should consult your doctor and stop taking the drug.
Special instructions for admission
Due to the fact that Riboxin and its metabolites are excreted mainly by the kidneys, the drug is not recommended in the presence of renal failure. The use of this drug can only be justified if the expected benefit of the drug exceeds the potential risk of its use. A similar rule should be followed when prescribing the drug to pregnant and lactating women.
Given the effect of "Riboxin" on the level of uric acid in the blood plasma, during therapy it is recommended to constantly monitor it in order to prevent the occurrence of hyperuricemia.
Poisoning and overdose of the drug
In the case of high doses of the drug, general measures are taken to reduce the flow of the drug into the bloodstream. In case of symptoms of poisoning - symptomatic therapy. When allergic reactions occur, desensitizing therapy is effective.
Riboxin: analogues
Today on the pharmaceutical market there is more than one analogue of Riboxin with an anabolic type of action. At the same time, there are both analogues with the content of another active substance, and complete synonyms of the drug, incorporating a similar active component.
Inosine may be a complete synonym and analogue of Riboxin for intramuscular administration. At its core, the drug is a complete substitute for Riboxin with all its indications and contraindications. Another synonym for the medication in question is Ribonosin. This drug also contains in its composition an active substance similar to the Riboxin preparation. An analogue for children in syrup is a drug such as Mildronate. It also has the ability to provide energetic homeostasis for almost all body cells.
If we consider a group of non-steroidal anabolic drugs, we can distinguish such Riboxin analogues in tablets as Methyluracil and potassium orotate. These drugs, although they belong to various pharmacological groups, however, can have an anabolic effect. Basically, this effect will be due to the stimulation of metabolic processes in all cells and tissues of the body.
Comparing with the drug "Riboxin" analogues of a new generation, we note that they have greater effectiveness and therapeutic effects. A worthy representative of this group is Cytoflavin. In addition to the cytoprotective and antioxidant effects, this Riboxin analogue has a pronounced stimulating effect on brain neurons.
Conclusion
Anabolic drugs are a wide group of drugs of various chemical structures. Depending on the purpose for which they are planned to be used, you can choose "Riboxin", analogues of the drug or pay more attention to the steroid group. Note that the independent use of these drugs is not recommended. Only a competent specialist will be able to help in choosing a medicine.