"Mildronate" is a medication that improves metabolism and energy supply of tissues. The drug is produced in the form of gelatin capsules of a milky hue, which contain a white powder. Mildronate contains one active substance - meldonium dihydrate in a dosage of 250 or 500 milligrams. Additional components are:
- Salt of calcium and stearic acid.
- Silica.
- Potato starch.
- Titanium dioxide.
- Gelatin.
The drug has angioprotective, as well as antihypoxic and antianginal effects. There are analogues and substitutes for Mildronate. Which to choose?
Indications
The medication is prescribed for the following conditions and diseases:
- Physical and mental strain.
- Decreased performance.
- Cerebrovascular insufficiency (a pathological process in the vessels of the brain in which the microcirculation of the blood of this organ is impaired).
- Stroke (acute violation of the microcirculation of blood in the brain, which leads to permanent damage).
- Myocardial infarction (a heart lesion that occurs with the occurrence of ischemic necrosis of a portion of the heart muscles, which is caused by the insufficiency of its microcirculation).
- Angina pectoris (a disease characterized by sensation or discomfort behind the sternum).
- Dyshormonal cardiomyopathy (a heart lesion that is associated with hormonal changes, as a rule, is observed in women aged 45-55 years).
- Abstinence syndrome (an ailment that occurs when the use of a psychoactive substance is completely stopped).
Limitations
The drug has certain contraindications:
- Hypersensitivity.
- Pregnancy.
- Age to eighteen.
- Increased intracranial pressure.
- Breast-feeding.
- Violation of the intracranial venous outflow.
How to take capsules
Due to the ability of the drug "Mildronate" to have an exciting effect, it must be consumed in the morning, before five in the evening. For coronary heart disease, as well as for chronic heart diseases, the drug is recommended for use as part of a combination treatment once or twice a day for four to six weeks. Daily dosage is 0.5-1 grams.
For people who suffer from heart disease associated with hormonal changes, Mildronate is prescribed as a complex therapy for twelve days, at 500 milligrams per day. In case of stroke and cerebrovascular insufficiency, the medicine is used in the structure of combined treatment of 0.5-1 grams 1-2 times a day for six weeks.
In the treatment of chronic disorders of blood microcirculation, Mildronate is used three times a year as part of a comprehensive treatment of 0.5 milligrams for 4-6 weeks. With physical and mental stress and decreased performance, the medicine is used twice a day at 500 mg for two weeks. If necessary, therapy is repeated after 21 days.
Athletes before training should take the drug twice a day, 0.5-1 grams before exercise for three weeks in the preparatory period.
How to use the drug in ampoules
With lesions of the cardiovascular system, the medication is used as part of a combined treatment twice a day, from 5 to 10 milliliters of solution. The duration of therapy is six weeks.
If there is a violation of the microcirculation of blood in the brain during the acute time of the disease, the medicine is administered intravenously, for ten days, 5 milliliters per day. Next, the patient is transferred to the use of the drug in capsules. The duration of treatment is six weeks.
In case of excessive mental and physical stress, Mildronate is administered intravenously for fourteen days, 5 ml, once a day. If necessary, after two to three weeks of therapy can be repeated.
With dystrophic lesions of the retina and vascular diseases, the medication is administered parabulbarly (into the peri-ocular region), 0.5 milliliters of a ten percent solution for injections.
People who suffer from chronic alcoholism are prescribed 5 ml of the drug twice a day for ten days.
Mildronate Cheap substitutes and analogues
The generics of this medication are:
- Mildrocard.
- Methonate.
- "Meldonium".
- Riboxin.
- Metamax
- "Cardionate".
- "Trizipin".
- Mildroxin.
- Idrinol
- Melfort.
Before buying a substitute drug "Mildronate" it is recommended to consult a doctor. Next, the most popular analogues will be considered.
Riboxin
The drug is in the form of tablets and a solution for parenteral administration. "Riboxin" improves myocardial metabolism and reduces the severity of hypoxia.
The substitute "Mildronate" in injections is used in the complex treatment of various pathologies of the processes of the cardiovascular system:
- There is an improvement in all metabolic processes in the cells.
- Stabilization of the frequency and rhythm of heart contractions.
- Increased myocardial resistance to reduced oxygen supply to cells in violation of proper blood microcirculation.
- It improves the strength of contractions of the heart muscle, enhances the stroke volume of the blood and helps to more fully relax the muscles during diastole.
In addition, the medicine reduces the production of platelets, due to which the prevention of intravascular formation of blood clots occurs and the restoration of damaged tissues is activated.
After using the domestic substitute "Mildronate" - "Riboxin", the active substances are quickly and completely absorbed into the bloodstream. The drug is evenly distributed in the tissues, exchanged in the liver with the formation of glucuronic acid.
"Meldonium"
The drug is considered popular for improving physical performance and recovery of the body after surgical interventions and past strokes.
"Meldonium" is recommended for eliminating ischemic heart diseases, as well as a chronic form of heart failure and as an element of the combination therapy of various disorders of blood microcirculation in the brain.
Substitute "Mildronate" in tablets is prohibited for patients under eighteen years of age, pregnant and lactating women. In addition, it is contraindicated to use the drug for people who suffer from increased intracranial pressure.
Before starting therapy, you should consult with a medical specialist. In case of impaired functioning of the liver or kidneys, care must be taken, especially when taking "Meldonium" for a long time.
Metamax
The drug is made in the form of capsules and injections. "Metamax" stimulates the immune system, and also has a cardioprotective effect, reduces the severity of unpleasant symptoms during physical and mental stress, increases the intensity of metabolic processes and improves working capacity. In acute ischemic tissue disorder, these effects of the drug help reduce the size of the necrosis zone and shorten the rehabilitation time.
Substitute "Mildronate" for athletes has a tonic effect on the nervous system. With prolonged treatment, it is necessary to monitor the functioning of the kidneys and liver.
"Metamax" can provoke adverse reactions that affect the ability to concentrate attention and speed of reactions, therefore, during therapy should refrain from hazardous activities, including driving vehicles and working with complex mechanisms.
"Metonat"
The medicine is in the form of a solution and capsules. The medication improves metabolic processes in the myocardium. With insufficient blood supply, Metonat restores the cellular balance between oxygen consumption and its delivery, prevents the violation of ATP transport, and stimulates glycolysis without additional oxygen consumption.
The drug helps to improve performance, as well as reduce the severity of symptoms of physical and mental stress, activation of the body's defenses. Has a cardioprotective effect.
In acute myocardial ischemia, the drug reduces the area of necrosis, and also reduces the rehabilitation time. Substitute "Mildronate" in ampoules improves performance, eliminates signs of mental and physical stress.
With ischemic disorders of blood microcirculation in the brain, Metonat improves blood circulation in the source of ischemia, and helps redistribute cerebral blood flow in favor of the affected area.
The medicine has a tonic effect on the central nervous system, it eliminates unpleasant symptoms, including with withdrawal symptoms in patients with chronic alcoholism. The medication also has a beneficial effect on the immune system.
Mildroxin
The drug is made in capsules. The drug improves the metabolism and energy supply of tissues. "Mildroxin" is considered a synthetic substitute for gamma-butyrobetaine, and also inhibits gamma-butyrobetaine hydroxylase, reduces the synthesis of carnitine. The drug has a cardioprotective effect, stabilizes myocardial metabolism.
The drug regulates cellular immunity, as well as functional disorders of the central nervous system in chronic alcoholism. Mildroxin helps redistribute blood flow to ischemic areas, including in the brain and retina.
When taken orally, it is well absorbed. The maximum content is reached after two hours. The elimination half-life varies from three to six hours.
Reviews
In most cases, people respond positively about the drug and its substitutes. Patients tell that medicines have a unique spectrum of action. They are used to eliminate diseases of the cardiovascular system. In addition, patients confirm that "Mildronate" improves performance, eliminates unpleasant symptoms during physical and mental stress.
And patients in cardiology departments, and doctors, and athletes note the fact that the drug has a tonic effect. When using it, memory improves significantly, and mental processes are accelerated, increased agility of movements, endurance and the degree of resistance of the body to the influence of harmful factors.
Reviews by cardiologists confirm numerous studies that have confirmed that the use of Mildronate in capsules and in the form of a solution for injections helps to reduce the incidence of recurrent myocardial infarction.
Patients' reviews of the drug help to conclude that Mildronate and its analogues are simply needed by people whose activity is associated with increased stress on the body, as well as during recovery from long alcohol abuse, pain and burning in the heart, vegetative dystonia and other cardiovascular pathologies.
However, the drugs also have negative responses. It must be remembered that any medication should be prescribed by a doctor.