"Miropriston" for the stimulation of labor: doctors reviews, instructions for use and indications

"Miropriston" is an antigestagen that is produced in the form of tablets. They have a cylindrical shape, a light yellow tint. The structure of the drug includes: mifepristone, sodium starch glycolate, calcium and stearic acid salt, talc, cellulose.

According to the instructions to Miropriston (to stimulate labor), tablets block the action of progesterone at the level of receptors, which do not have progestational activity.

Beneficial features

They improve the contractility of the muscle layer of the uterine wall, which consists of three layers of smooth muscle fibers. In addition, the drug increases the sensitivity of the myometrium to prostaglandins.

According to the instructions and reviews to Miropriston for the stimulation of labor, the drug helps to peel off the decidual membrane and remove the fetal egg. The half-life is approximately eighteen hours.

When the drug is prescribed

The medication is intended to stop uterine pregnancy (up to 42 days without menstruation). Miropriston is used simultaneously with misoprostol, and it is also intended for the preparation and stimulation of labor.

Limitations

Contraindications:

1. Uterine fibroids - a benign tumor that occurs in the muscle layer of the uterus.
2. Hemostasis disorders (a biological system that maintains a liquid state of the blood in the body is normal).
3. Acute or chronic diseases of the liver and kidneys.
4. Adrenal insufficiency.
5. Porphyria is a hereditary disorder of pigment metabolism with an increased content of porphyrins in the blood and tissues and with their increased excretion in urine and feces.
6. Conducting prolonged glucocorticosteroid treatment.
7. Smoking from the age of 35 years.
8. Increased Sensitivity.

Restrictions on medical abortion:

1. More than 42 days of amenorrhea (absence of menstruation for 6 months in a woman who previously had a normal menstrual cycle).
2. "Interesting position" not confirmed by clinical studies.
3. Ectopic pregnancy.

What other contraindications does the drug have

Prohibitions on the preparation and induction of labor are:

1. Vaginal discharge of unknown origin during pregnancy.
2. Eclampsia is a disease that occurs during pregnancy, as well as childbirth and in the postpartum period, in which blood pressure reaches such a level that there is a threat to the life of the mother.
3. Complex pregnancy, which requires frequent monitoring and therapy in a hospital setting.
4. A complication of a normal pregnancy, which may or may not be manifested by edema, increased pressure, loss of protein in the urine, convulsions.
5. Abnormal position of the fetus (a clinical situation in which the axis of the fetus forms a right or an acute angle with the longitudinal axis of the uterus, there is no present part).
6. Severe forms of hemolytic damage to the fetus.

According to the annotation, the drug "Miropriston" should be used with extreme caution in the following situations:

1. Heart disease.
2. Arterial hypertension (a disease characterized by high blood pressure).
3. Bronchial asthma (damage to the respiratory system, which is characterized by asthma attacks of varying duration and frequency).
4. Obstructive pulmonary disease (a disease characterized by a partially irreversible restriction of air flow in the respiratory system).

Instruction manual

Miropriston tablets are used only in medical institutions that are equipped with special equipment, under the supervision of a doctor. In the presence of a specialist, a woman takes 3 tablets once (a total of 600 milligrams of mifepristone), washed down with boiled water.

It is necessary to use the drug 1-1.5 hours after breakfast. After 36–48 hours, the patient should appear in the hospital to use misoprostol at a concentration of 0.4 milligrams.

After 10-14 days, an examination is carried out. If necessary, determine the level of hormones to confirm that the pregnancy was terminated.

According to the instructions and reviews of Miropriston for the stimulation of labor, it is known that if after two weeks the effect is not observed, a mandatory vacuum aspiration and subsequent histological examination are prescribed.

Birth preparation:

1. In the presence of the doctor, the expectant mother takes a Miropriston tablet once. After a day, the procedure is repeated.
2. After another three days, the birth canal is assessed; if necessary, Oxytocin or prostaglandins are used.

Adverse reactions

Miropriston can provoke the following negative actions:

1. Migraine.
2. Hyperthermia is the accumulation of excess heat in the body with an increase in temperature, which is triggered by factors that cause poor heat transfer.
3. Nausea.
4. Vomiting.
5. Nettle rash.

Termination of pregnancy may be accompanied by pain in the lower abdomen and vaginal bleeding. In addition, an exacerbation of inflammation of the uterus and appendages is likely. Reviews on Miropriston tablets for stimulation of labor are usually positive.

"Miropriston" is used not only to prevent unwanted pregnancy, but also to stimulate labor. Not always with a positive course, labor also occurs and passes according to plan - sometimes you have to resort to drugs.

How long does Miropriston act to stimulate labor? The medicine must be consumed strictly as prescribed by the doctor and only in medical institutions that specialize in female reproduction.

Labor activity is noted in the next 2-3 days after taking the drug. On average, labor begins 60 hours after the second pill.

According to reviews of Miropriston for stimulation of labor, a pregnant woman after taking the drug should be under medical supervision and report any changes in her condition. Already in the first hours after consuming the first pill, pain in the lower back is noted, it is possible to note the passage of the mucous plug.

All these unpleasant sensations, as a rule, gradually increase, clearly intensifying after the second pill. If 2 days after taking the second pill, not even a hint of stimulation is noted, another, stronger medication is prescribed.

Substitutes

Generics of "Miropriston" are:

1. Agesta.
2. Gynestril.
3. "Zhenale."
4. "Mifegin."
5. Mifepristone
6. Pencrofton.

Shelf life is 60 months. They are used only in a hospital setting.

Opinions

Most of the reviews of doctors about Miropriston for stimulation of labor are positive. Women tell about the increased efficacy of the drug both in the case of pharmaceutical abortion in the early stages, and during the stimulation of childbirth.

But there are also individual responses in which representatives of the beautiful half share their negative experience with the use of this drug. As a rule, we are talking about breaking the "interesting situation."

According to the reviews of Miropristone for labor stimulation, it is known that women indicate either pronounced negative effects of the drug or a complete lack of action, which entailed the need for vacuum aspiration.