What is the medicine "Dipyridamole"? The instruction, price, properties and indications of this tool will be presented later. We will also tell you about whether it is possible to take the drug during pregnancy, whether it has analogues, adverse reactions and contraindications.
Composition, packaging and form
What does the instructions for use say about the drug? "Dipyridamole" is a drug that has several forms of release. Let's consider them in more detail:
- Dragees of 0.075 and 0.025 g. The active substance of this form is dipyridamole. The drug is sold in plastic packages of 100 pieces.
- "Dipyridamole" - tablets of 0.075, 0.005 and 0.025 g. Coated, they also contain such an active substance as dipyridamole. As for the auxiliary elements, they include calcium stearate, lactose monohydrate and starch. The medicine goes on sale in cell packs of 120 or 40 pieces, which are placed in packs of cardboard.
- Injection. This form includes a similar active substance. 0.5% solution is sold in 2 ml ampoules.
Pharmacodynamics
What properties does the medication in question have? What does the attached instructions for use say about this? "Dipyridamole" is a drug that has a vasodilating effect. He exerts such an effect mainly on the coronary vessels.
The accepted dosage of the drug inhibits platelet adhesion, increases blood flow velocity, improves microcirculation and has an angioprotective effect. In addition, the agent in question promotes collateral circulation in the vessels of the heart.
We can not say that this drug normalizes venous outflow. Therefore, its regular intake significantly reduces the risk of thrombosis, especially in the postoperative period.
Operating principle
What other properties does the medicine “Dipyridamole” have? The instruction says that this tool well reduces the tone of the vessels of the brain. In this regard, it is quite actively used in transient ischemic attacks. In addition, the drug in question significantly improves placental circulation. This property helps prevent fetal hypoxia.
What is the mechanism of action of the drug? What information does the instructions for use contain? "Dipyridamole" increases the activity of adenosine, and also reduces its uptake by tissues. The mentioned substance affects the muscles of the blood vessels, blocking the release of norepinephrine, which, in fact, causes their narrowing, increasing OPSS and blood pressure.
It should also be said that as a result of blocking phosphodiesterase, the release of platelet aggregation activators is reduced. This property prevents them from sticking together. Moreover, a decrease in platelet adhesion prevents the formation of blood clots in the vessels.
The drug "Dipyridamole", the price of which is indicated below, as a disaggregant is often used in conjunction with acetylsalicylic acid.
Pharmacokinetics
The agent in question is absorbed quite quickly. Its maximum concentration is achieved approximately 60 minutes after administration.
The accumulation of the active substance is carried out in myocardiocytes. The drug is metabolized in the liver. In case of violation of the work of this body, cumulation is possible.
Indications for use
The medicine "Dipyridamole" is prescribed for the following diseases:
- chronic coronary insufficiency;
- for the prevention of occlusion of shunts and stents;
- angina attacks;
- myocardial infarction (only not in the acute stage);
- venous as well as arterial thrombosis;
- ischemic stroke;
- prevention of thromboembolism, especially after heart surgery;
- placental insufficiency;
- encephalopathy discirculatory;
- atherosclerosis of the vessels of the legs;
- microcirculatory disorders of any origin;
- glomerulonephritis;
- DIC in a child with sepsis and toxicosis.
Contraindications
According to the instructions, the tool in question cannot be used in the presence of the following deviations:
- arterial hypotension ;
- unstable angina pectoris;
- acute myocardial infarction;
- hypersensitivity;
- severe forms of arrhythmias;
- decompensated heart failure;
- liver failure;
- hemorrhagic diathesis;
- gastric ulcer, especially with a tendency to bleeding.
It should also be said that this medication is prescribed with special care to children under 12 years of age and during lactation. In addition, you can not use the drug intravenously with collapse.
Instructions for use
"Dipyridamole" is an antithrombotic drug, which should be prescribed only by your doctor.
As a rule, tablets and dragees are taken orally 60 minutes before a meal with a glass of water. In order to reduce the irritating effect on the gastric mucosa, this medication can be washed down with warm milk.
Dosage and methods of use of the drug should be determined only by a doctor, depending on the age of the patient, indications and his health.
For the prevention of thrombosis, 75 mg of the drug is prescribed 6 times a day (maximum dose per day - 300-450 mg).
With coronary insufficiency , 25-50 mg of the drug is used three times a day. The maximum dose in this condition is about 150-200 mg.
In order to prevent thrombosis of shunts and a stent, the patient is given 50 mg of the drug (four times a day) together with acetylsalicylic acid. The medication is used before the operation, as well as within a week after it.
With obliterating vascular diseases of the lower extremities, it is recommended to take 75 mg of the drug three times a day.
The daily dosage of the drug for children depends on their weight (5-10 mg per kg).
According to the instructions, during treatment it is necessary to limit the use of tea and coffee, as they can weaken the effect of the drug.
Overdose
When using high doses of the drug, the patient may experience the following symptoms: decreased blood pressure, dizziness, increased bleeding, and palpitations. In this case, it is necessary to cancel the drug and consult a doctor.
Adverse reactions
According to patient reviews, in some cases, taking the drug in question can cause the following side effects:
- allergic reactions;
- cardiopalmus;
- decrease in blood pressure (especially with intravenous administration);
- thrombocytopenia;
- headaches;
- dyspeptic disorders;
- noise in the head;
- hyperemia of the face;
- tachycardia;
- increased bleeding or bleeding.
Drug interaction
The antiplatelet effect of this drug is enhanced while taking acetylsalicylic acid, tetracycline, penicillin, cephalosporin, indirect anticoagulants and nicotinic acid.
It should also be noted that indirect anticoagulants, thrombolytics and heparin can increase the likelihood of hemorrhagic complications.
It cannot be said that caffeine-containing drugs and xanthines reduce the vasodilating and antithrombotic effects of the drug in question, and antacids reduce its absorption and blood concentration.
As for the drug itself, it enhances the effect of antihypertensive drugs.
Can I use Dipyridamole medication during pregnancy?
Experts say that against the background of taking the drug in question, pregnant women do not have complications. On the contrary, the drug "Dipyridamole" during pregnancy is very often prescribed if there is a threat of miscarriage or fetoplacental insufficiency.
Prices and analogues
What can replace the medicine "Dipyridamole"? The analogs of this tool are listed below. These include the following drugs: "Parsedil", "Curantil", "Padicor", "Antistenocardin", "Trancocord", "Stenocardyl", "Persantine", "Dipyridamole-Fereyn". All of the listed drugs have the same active substance. However, they may have different side effects and contraindications. In this regard, it is recommended to use these funds only after consulting a doctor.
How much is the drug "Dipyridamole"? Its price ranges from 380-420 rubles (depends on the quantity and form of release of the drug).
Reviews
Most often, those patients to whom it was prescribed for the prevention and treatment of premature aging of the placenta, as well as placental insufficiency, leave their reviews about this drug.
It should be noted that pregnant women tolerate such a drug quite well. Only some women have adverse reactions in the form of lowering blood pressure and dizziness.