The drug "Ceftriaxone" (release form - powder for solution preparation) belongs to the category of semi-synthetic third-generation antibiotics. The drug has a bactericidal effect, provoked by inhibition of synthesis in the cell wall of the pathogen. The medication is characterized by a fairly wide spectrum of action. So, the medicine is active in relation to gram-positive and gram-negative microorganisms. The drug is resistant to beta-lactamases.
Indications
The drug "Ceftriaxone" (injections) is prescribed for sepsis, meningitis, wound infections. The drug is recommended for infections in the bones and joints, ENT organs, urinary tract and kidneys, soft tissues and on the skin. It is also indicated as infection prevention after operations. Indications include gonorrhea, infections of the genital organs, respiratory tract, pelvic organs, and abdominal cavity.
Mode of application. Dosage
The Ceftriaxone injection is given intramuscularly or the drug is injected into a vein. Patients from twelve years old are recommended one to two grams per day. In cases of severe course of the pathology, a dosage increase of up to four grams is allowed. For children whose weight is more than fifty kilograms, dosages are prescribed, as in adults. Patients under twelve years of age, including infants, are recommended twenty or eighty milligrams per kilogram of weight. Per day for newborns, the dosage should not be more than 50 mg / kg of weight. The duration of the use of Ceftriaxone (injections) depends on the nature of the disease. After completing the main treatment and confirming the absence of the pathogen in the body and normalizing the temperature, it is recommended that the drug be administered for another two or three days. The powder is dissolved in a ratio of one gram per three and a half milliliters of
water for injection. The drug "Ceftriaxone" (injections) is injected into the buttock, not more than a gram in one place. The use of a one percent solution of “Lidocaine” means when injecting reduces pain.
Adverse reactions
Against the background of the use of the drug, the development of dyspeptic phenomena is likely . In particular, patients develop diarrhea, vomiting, constipation, nausea, and an upset taste. In addition, the medicine can cause pseudomembranous enterocolitis, dysbiosis, anemia, thrombocytopenia, leukocytosis. In some cases, impaired renal activity, oliguria, anuria, erythema (multiform), serum sickness, fever, bronchospasm, urticaria can develop. In rare cases, anaphylactic shock is noted . Adverse reactions include nosebleeds, superinfection, candidiasis.
Contraindications
The drug is not prescribed during gestation, with hypersensitivity to cephalosporins, penicillins. No medication is prescribed during lactation. Ceftriaxone (injections) is contraindicated in premature and newborn children with hyperbilirubinemia, persons suffering from enteritis and colitis, provoked by antibiotic therapy, as well as in case of impaired renal and hepatic activity.