When we are healthy, we don’t think at all about pills and medicines. It seems to us that this will last forever, but the disease usually sneaks up unnoticed and forces us to look for the most effective way to get rid of the symptoms. Doctors around the world are alarmed by how often modern people encounter diseases of the stomach and duodenum. Most often, they suffer from symptoms of an ulcer, which is known to be caused by a bacterium. Previously, the causes of this disease were called stress, malnutrition and other similar factors. Based on them, the doctors selected a treatment that most often turned out to be ineffective. Today, many drugs have been developed that can once and for all rid you of a peptic ulcer. Very popular among our compatriots is De-Nol. Instructions to it allow you to find out exactly how to use the drug and what side effects it can cause. From our article you will learn what determines the effectiveness of this drug. We will also consider, in addition to the instructions for "De-Nol", and analogues of the drug, which can be purchased in Russian pharmacies.
General description of the drug
Instructions for use with the drug "De-Nol" allows patients to determine the treatment regimen and its duration. However, like any other medicine, doctors do not recommend taking it without consulting your doctor. Moreover, improper and untimely treatment of an ulcer can lead to its exacerbation, accompanied by bleeding.
The manual and reviews of De Nola provide a complete description of it. Tablets are anti-ulcer drugs that have, among many others, an astringent effect. Patients and doctors especially appreciate the antibacterial and gastroprotective effects of the tablets. Thus, they not only neutralize the bacteria that cause ulcers, but also remove the effects of their activities in the body, which can poison any person for a long time.
Pharmacists claim that De-Nol (the instructions for it confirm the facts we have stated) forms on the walls of the stomach a very thin film that protects the mucous membrane. It is especially important in those places where erosion and other injuries have already formed in the course of the disease.
It is confirmed that after the course of treatment with De-Nol, according to the instructions (reviews often provide information on the high effectiveness of the drug), the body becomes resistant to the effects of bacteria that provoke the disease. In such patients, the risks of relapse are minimized. We can say that the drug makes it possible to completely recover and never again remember the ulcer and the symptoms that accompany it.
The instructions to "De Nol" indicate that it is mainly excreted from the body by the gastrointestinal tract. However, part of the constituent tablets is able to penetrate into the plasma, therefore, their withdrawal is carried out only with urine. It is noteworthy that the drug is considered one of the safest. It is prescribed to the vast majority of patients who are diagnosed with peptic ulcer.
Drug Release Form
Before taking the drug, you must carefully read its instructions for use and reviews. "De-Nol" in tablets is the only form of release of this medicine. All other options are fake and have nothing to do with the original. The manufacturer made sure that his tool was quite difficult to fake even externally.
The instructions for "De Nol" describes in detail the appearance of the tablets. They have a pleasant cream shade and are distinguished by a convex shape. A specific pattern is embossed on the tablets on both sides: letters and numbers are on the one, and a characteristic quadrangle with rounded edges is on the other. The product is odorless, but in rare cases, a faint ammonia aroma is acceptable.
As written in the instructions for "De Nol", the manufacturer places the tablets on a blister. Usually there are eight capsules on it. Blisters are packed in a cardboard box, there are two options for filling it: fifty six and one hundred and twelve tablets. Thus, in a pharmacy you can buy a drug with seven or fourteen blisters.
The composition of the drug
The composition of the De-Nol tablets in the instructions for use is described in sufficient detail and clearly. But we still pay attention to this topic in the current section of the article.
When purchasing these pills, keep in mind that they have a lot of different substances. In addition to the main one, stated on the package, auxiliary and those that form the shell are included in the composition.
The main component is bismuth tripotassium dicitrate. It is it that is a substance that can neutralize the bacterium that causes the ulcer and envelop the wall of the stomach with a film, forming a protection for the inflamed sections of the mucous membrane. One tablet contains a little over three hundred milligrams of the active ingredient. These data are usually always placed on the packaging of the medicine and are indicated in the instructions for the drug "De-Nol".
Among the auxiliary substances, the most significant mass fraction of corn starch, povidone and magnesium stearate. This is not a complete list of components. If you are interested in the entire list of additional components, then you can familiarize yourself with it in the instructions for the medicine "De-Nol".
The shell of the tablets allows you to start the absorption of bismuth in those parts of the gastrointestinal tract where they can have the most powerful effect on bacteria. It consists of the following substances:
All of these components are completely safe for the human body, which is proved by clinical trials.
Pharmacology
In the instructions for use of "De-Nola" (analogues of the drug can not always fully replace the original), it is noted that it has a very wide spectrum of action. They are usually divided into two categories:
- protective and restorative:
- antimicrobial.
The first group includes the following effects on the patient's body:
- The formation of a protective film. The active substance of the drug reacts with the proteins of the human body. As a result, a film forms on the damaged areas of the mucous membrane, it prevents the gastric juice from reaching these areas and further irritates them. Thanks to this, their healing is accelerated.
- Strengthening the mucous membrane. De-Nol promotes the production of the hormone necessary to strengthen the walls of the mucosa. Some time after the start of taking the drug, the formation of mucus in the body increases, which is necessary to protect the stomach and duodenum.
- Regulation of enzyme production. During treatment, the amount of pepsin in the stomach decreases. Thus, areas damaged by bacteria are not further irritated.
- Improving blood supply. "De Nol" helps to accelerate metabolic processes in the body, improving blood circulation to damaged tissues. Thus, they are restored in a faster time.
The medicine “De-Nol” (instructions for use is enclosed in each package) would not be so effective if it did not directly destroy the bacteria that cause peptic ulcer. The active substance of the tablets inhibits the cellular fermentation of microorganisms, their vital functions. In parallel, the membrane of the cell membrane is broken, and bacteria lose the ability to settle on the walls of the stomach. After several days of exposure, Helicobacter loses its mobility and can no longer be as mobile as before. One of the advantages of De Nola is the fact that resistance to its basic substance is not developed. With subsequent infections, the patient can again use the drug without fear that in these cases it will be useless.
Indications
The instructions for the drug "De-Nol" noted in which cases it can be used. First of all, this medication may be prescribed for you if the examination showed an ulcer. The disease itself is a banal damage to the mucosa by the bacteria Helicobacter pylori. They can be localized in the stomach and duodenum. In addition to bacteria, such damage is caused by increased production of hydrochloric acid or regular emissions of bile.
Also, "De Nol" helps with gastritis and inflammatory processes occurring in the duodenum. Often, the drug is prescribed for dyspepsia. Symptoms of this problem are expressed in painful and pulling sensations under the stomach. If the doctor does not detect other lesions, and the pain lasts more than three months, then most likely he will prescribe the patient "De-Nol".
In recent years, the tablets we have been describing are also being taken for functional problems with the intestines. Most often they are combined under one term - "irritable bowel syndrome". Its symptoms are familiar to many residents of large cities who do not have time to eat properly and regularly. They often feel bloating, pain, discomfort, and also suffer from diarrhea or, conversely, from constipation.
Who should not drink the drug?
If you are pregnant, then even with exacerbation of peptic ulcer disease, you must abandon De-Nola. Its components can cause mutations in the baby and cause other deviations in its development. It is worth refraining from this medicine and nursing mothers. The active substance easily penetrates into breast milk and is able to strike a crumb in the nervous system. It is known that De-Nol can cause severe kidney damage.
If you previously had allergic reactions to the drug, then taking it again will be unreasonable. The manufacturer warns that it is forbidden to drink tablets in cases where there are already bismuth products in your treatment regimen.
Instructions: how to take "De-Nol"
The drug is prescribed for the treatment of adults and children who have reached the age of twelve. Doctors usually follow two pill regimens. Making an appointment, they proceed from the diagnosis and severity of the disease.
The first scheme involves a four-time intake of tablets. Half an hour before a meal, the patient should drink one De-Nola capsule. The last pill is taken just before going to bed.
According to the second scheme, the medicine is drunk twice a day - in the morning and evening hours. However, you must take two tablets at a time, while maintaining the same time interval - thirty minutes before eating.
The tablets can not be chewed, while you need to drink them with a large glass of clean water. If possible, you can drink two glasses of liquid.
In rare situations, doctors prescribe De Nol to children under twelve years of age. The medication regimen is one tablet twice a day, a similar treatment is suitable for babies from eight to twelve years old. For young children, the dosage is calculated taking into account body weight. For one kilogram of weight, you can take eight milligrams of bismuth.
Typically, the duration of treatment does not exceed eight weeks. If during this time it was not possible to get rid of the disease, then you can return to De-Nola only after two months. The fact is that its active component is moderately toxic and, with prolonged use, can cause severe damage to internal organs.
Side effects
In general, the reviews about the De-Nol treatment are positive, it is well tolerated and gives a good therapeutic effect, but in some cases, patients encountered a number of unpleasant symptoms.
People prone to allergies can notice redness of the skin, feel itchy and even notice some swelling. Side effects include problems with daily stools, as well as nausea, vomiting and darkening of the mucous membranes of the oral cavity.
With long-term use of the drug in large doses, we can talk about serious damage to health. For example, brain damage, decreased attention and memory impairment are possible.
Talk about overdose
We have already specified that bismuth is a rather toxic substance, therefore its overdose is extremely dangerous for the body. If the patient took it for a long time and exceeded the dosage prescribed by the doctor, then it is likely that he will have all the symptoms of poisoning. They are expressed in the appearance of a black border on the gums, nausea, vomiting, discomfort in the stomach. Often an overdose is accompanied by renal and liver failure. The patient decreases the frequency and intensity of urination, thereby increasing the concentration of toxic substances. At the same time, itchy skin, sleep loss and exacerbation of hypertension are possible.
If you diagnose symptoms of overdose in time, the condition will be completely reversible. Some time after stopping treatment, all toxic substances are excreted from the body naturally. In rare cases, when the problem has already passed into an advanced stage, hospitalization may be necessary.
Analogs of "De Nola"
The instructions for use of the original drug do not list its analogues, but in fact their list is wide. In this case, you can find among the full analogues, as well as funds that are similar only in therapeutic effect.
For example, many patients often replace De-Nol with Novobismol. These drugs are complete analogues and are able to replace each other. The only difference between them can be considered manufacturers. Novobismol has a number of significant advantages: the ability to drink it in parallel with antibiotics, low cost, not exceeding 700 rubles, and high efficiency in the treatment of exacerbations of gastritis. Of the minuses, patients note a short course of administration and the inability to treat children up to four years old.
Belgian tablets "Pariet" is a very expensive antiulcer drug. It is sold in pharmacies for four thousand rubles and is not available to most patients. However, it gives a high result, and the regimen is suitable for those who are very busy and cannot take the medicine several times a day. But it is worth considering that the "Pariet" causes a huge number of adverse reactions, which excludes its appointment to children under twelve years of age.
Some doctors prescribe for Venter peptic ulcer. This drug is produced in Slovenia, and it is very affordable - the maximum price limit does not exceed three hundred rubles. Its active substance has a very mild effect on the body, so it practically does not cause side effects. Also, it is absolutely harmless to the kidneys and urinary system, and therefore it is taken even by patients who are forced to regularly perform dialysis.
The Indian drug Omez D is well known to people suffering from ulcers. Usually, capsules are drunk twice a day, this amount is enough to permanently forget about many diseases of the gastrointestinal tract. In addition, this medicine improves the general condition of the patient and is not prone to cause negative side effects.