The drug "Colme" is actively used to treat chronic alcoholism and relapse prevention. Reviews of drug addicts about the medicine are mixed, and since the summer of 2017, drops have completely disappeared from Russian pharmacies. "Colme" is now brought to Russia privately from Spain or other countries where the sale of medicine is permitted. In this regard, the urgent question is not only about the use of "Colma", but also about effective analogues of this drug.
Alcohol addiction
In Russia, there is practically no culture of the correct use of alcoholic beverages. Censure, of course, is heard, but these words usually do not sound very convincing. The patient calmly drinks alcohol at home, relatives, as a rule, are happy with everything. Relatives begin to worry only when a persistent addiction has already formed. Person degradation and violation of moral attitudes.
The official numbers are disappointing. According to statistics, each person in the CIS expands more than ten liters of pure alcohol per year. This is approximately 20-22 bottles of vodka for each, considering (the statistics are the same total) of infants and the elderly. According to WHO, the former republics of the USSR have almost passed the point of no return. This requires that 20% of the population be addicted to alcohol or drugs.
Keep in mind that these are only official numbers. That is, exactly so many people are registered with the addiction clinic. It is not possible to calculate real statistics. To get a more or less real picture, the official figure needs to be multiplied several times.
Alcoholism Treatment Tactics
Any treatment begins with giving up alcohol. It is difficult for the patient to tolerate. Detoxification of the body is necessary, because only against this background can you begin to develop an aversion to alcohol. To remove the binge, the patient is given a dropper that cleanses the body and restores the functions of internal organs. An injection of magnesia and vitamins also helps, which relieves nervous tension and helps to restore normal sleep.
In the future, medical treatment is used, but the doctor should prescribe the drugs solely based on the results of the medical examination. Most drugs reduce cravings for alcohol, produce indifference to alcohol, and when interacting with alcoholic beverages, they cause a serious condition characterized by a complex of extremely unpleasant symptoms. In some cases, even death is possible if the patient will combine the use of drugs with alcohol.
In addition, a consultation with a psychologist or psychotherapist is necessary, as depression often contributes to the uncontrolled use of alcoholic beverages. Physiotherapy is shown, namely dreamer- and TES-therapy, which contributes to the development of our own “hormones of joy” and stabilizes brain processes. Also, these methods are used in the treatment of insomnia, various neuroses.
Composition and principle of action
The active substance of the drug "Colme" is cyanamide (0.9 g). Under industrial conditions, the substance is obtained by hydrolysis of calcium cyanamide, which, in turn, is obtained from calcium carbide by the Franco-Caro reaction. The reaction is carried out in an aqueous solution. In this regard, most commercial preparations of cyanamide are available in the form of drops in dark glass ampoules of 15 ml each, which can be purchased in pharmacies only by prescription. Dosing dropper included.
According to the instructions for use, "Colme" is a liquid without color and taste, there is a very faint smell of vinegar. The drug mixes well with food and is almost invisible, which creates the temptation to treat anonymously, that is, so that the patient does not know about therapy. But the treatment of alcoholism must be carried out under the supervision of a doctor, including on an outpatient basis. The patient must be aware of the dangerous consequences of the combination of such drugs with alcohol or drugs containing ethyl alcohol.
An abstract to Colma indicates that the principle of action of the drops is similar to disulfiram-based preparations. This substance is prescribed in the treatment of alcoholism, there is the possibility of therapeutic use for cancer patients. Promotes the development of a stable negative reflex for taking alcoholic beverages. When treating this drug, doctors often resort to provocation. After taking disulfiram, the patient is given 20-80 ml of vodka or a bottle of beer, the resulting reaction provokes poisoning.
The action of Colme drops is based on blocking the enzyme that takes part in the metabolism of ethyl alcohol. This leads to an increase in the concentration of the metabolite of alcohol, which causes symptoms (when combined with alcohol), such as shortness of breath, hyperthermia of the skin of the face, nausea, heart palpitations. All this makes drinking alcohol extremely unpleasant while taking “Colme”, and produces a conditioned reflex aversion of the patient to alcohol.
According to reviews of Colma, the active effect of the main substance begins 40-60 minutes after taking the medicine. The action lasts for 12 hours. In this case, there is no hypotonic effect, that is, a rapid decrease in pressure, as is the case with some other similar drugs. The medicine only blocks the enzyme that breaks down ethyl alcohol, without affecting other enzymes.
People taking drugs with disulfiram in reviews of "Colma" indicate that the drops act less time. But at the same time, the medicine is less toxic than analogues with disulfiram, does not block the production of other enzymes. So, the composition of "Colme" provides a more selective action, but less long. The severity of symptoms when taking alcohol in both cases depends on the dose of alcohol consumed.
Indications and contraindications
The drug "Colme" can be taken only as directed by a doctor. The medicine is included in list B. These are potent pharmacological drugs that are prescribed with caution due to possible complications when taken without medical supervision. The main indication for use is alcoholism in a chronic course. Colme is also prescribed in ampoules in order to prevent relapse after a course of therapy. The effectiveness of "Colme" in the treatment of alcohol dependence is confirmed.
The drug is prescribed if the patient has an unstable attitude to sobriety during the treatment of chronic alcoholism. The first time you can take the medicine no earlier than 12 hours after the last alcohol consumed. Drops are well tolerated and absorbed, if you do not use alcohol or drugs containing ethyl alcohol at the same time.
The list of contraindications is indicated in the instructions for use. "Colma" is not prescribed for severe pathologies of the liver and kidneys, diseases of the heart and blood vessels, intolerance to certain components of the drug (both the main substance and the additional ones: sorbic acid, acetic acid, sodium acetate).
They prevent the appointment of drops of problems with the respiratory system, endocrine glands (patients with diabetes, with thyroid pathologies, and so on), epilepsy. The Kolme medicine is contraindicated for pregnant and breast-feeding women. Some doctors, claiming that there is no such alcoholic who would not be ill with any of the above diseases, recommend dropping drops in the treatment of alcoholism, so as not to provoke other health problems.
The effectiveness of "Colme" in alcoholism
According to experienced narcologists, when the addiction has already formed, an alcoholic can not drink alcohol in a controlled manner. Practical experience and scientific evidence prove that either a patient with alcoholism observes complete sobriety or drinks again uncontrollably. A sick person will not be able to take the drug and fight addiction without the support of relatives and friends, as well as doctors.
Colme is not a panacea. The medicine only provides a negative reaction of the body to alcohol. After sober, the patient very quickly begins to feel weakness, increased sweating, nausea, "pulsation" in the head, chest pain. The medicine refers to strong drugs. According to reviews, Kolme combines not only pronounced action, but also safety, which is also important.
However, the treatment of alcoholism is unacceptable with the drug alone. Therapy must be comprehensive, only then can long-term sobriety (remission period) be achieved. Everything is complicated by the fact that alcoholism is a chronic disease, including that associated with the psyche, prone to recurrence.
A universal pill does not exist, and treatment should be carried out by complex methods. A patient with alcoholism needs psychological rehabilitation, medical treatment, and physiotherapeutic procedures. Only in this case, we can expect a speedy improvement in human health, as well as its social status (normalization of family relations, position at work).
Instructions for use
The drug can be prescribed only by the attending physician and only after a preliminary medical examination, having weighed all the risks. The drug, as already mentioned above, belongs to the list of B (potent), so it should be used with extreme caution. Self-medication is unacceptable. The medicine "Kolme" is sold in pharmacies only by prescription.
The effective dose in each case is also determined by the narcologist. It is unacceptable to make a decision on whether to increase or decrease the dosage. How to take "Colme"? Depending on how severe the alcohol dependence is, 12 to 25 drops are prescribed at a time. It is necessary to take "Colma" from alcoholism twice a day with an interval of 12 hours.
The course of therapy averages from five to seven days. The first intake is possible no earlier than twelve hours after drinking. As for the duration of treatment, some narcologists in their reviews of “Colma” note that there are no restrictions in this regard. You can prescribe these drops for regular administration for several months, as well as for urgent prevention of breakdowns during exacerbation of pathological cravings for alcohol or in cases of increased risk of alcoholization.
After the first use, "Colme" usually do an alcohol test. Four hours after administration, the patient is given a drink of a little ethyl alcohol. In the event that the body gives the correct reaction, therapy should be continued. The correct reaction means the appearance of symptoms of poisoning:
- a short decrease in visual acuity;
- nausea, shortness of breath, and chest pain;
- heart palpitations, "pulsation" in the head;
- increased sweat, severe hyperthermia;
- palpable general weakness.
In severe cases, vomiting occurs, blood pressure decreases, breathing may be difficult.
Feasible side effects
The manufacturer claims that the occurrence of any negative reaction to the drug is unlikely, since Colme is well absorbed. But nevertheless, practicing narcologists highlight such possible side effects of Colme:
- yellowness of the skin;
- noise in ears;
- metallic taste in the mouth;
- severe migraines;
- allergic reactions;
- neurotic reactions.
The last condition is worth considering separately. This medical term includes a specific set of features and components. Neuropathic reactions are characteristic for those cases when severe stress occurs suddenly or accumulates over a long period of time, as a result of which adaptation mechanisms are no longer able to cope with psychoemotional stress.
At the same time, behavioral reactions are violated (usually a short-term phenomenon), a person may be aggressive or, conversely, shut down in himself. Physical sensations also vary: headaches, weakness in the extremities, general discomfort, fatigue, a feeling of heaviness in the head, blanching of the skin, sweating, and a rapid heartbeat may be characteristic. Some patients are characterized by short bowel or urination disorders.
When these symptoms appear, you should immediately stop taking "Colma". With an overdose on the background of a negative reaction to the body (without drinking alcohol), intensification of unpleasant sensations is possible. In severe cases, depression of consciousness to a state of coma is possible. The antidote does not exist. The treatment is symptomatic. Therapy consists in washing the digestive tract, monitoring the patient's condition. In some cases, a blood transfusion is performed.
Combination with other medicines
The drug should be prescribed with extreme caution, since combining with drugs containing ethyl alcohol will cause the same reaction as with alcohol. The use of "Colme" with "Phenytoin", "Metronidazole", "Isoniazid" is unacceptable. If the patient was taking medication with disulfiram, then treatment with Colme should be started no earlier than ten days after the previous course.
Testimonials from practitioners
Reviews about "Colma" from drug addicts are mixed. Some doctors say that the drug is quite effective and non-toxic, and side effects are very rare. Even with a single use for the prevention of disruption, the positive effect persists even for several days. Other narcologists argue that the symptoms when combined with alcohol are so severe that the drug should be prescribed very carefully, and it is even better to opt for less effective drugs. In the case of Colme, a breakdown may lead to clouding of consciousness to a coma.
Doctors unequivocally say that self-treatment "Colme" is very dangerous for health. In the conditions of a medical institution, tests, ultrasound, a complete examination of the patient with alcoholism are first carried out, and only then a decision is made on the purpose of the medicine and dosage. Extremely negative reactions can occur if you do not follow the doctor's recommendations and the scheme for taking drops. Some narcologists allow the use of "Colme" only in a hospital setting, and for less active treatment, less active drugs are recommended.
Issue price and conclusion
How much does Colme cost? At the beginning of 2017, this question could be answered unambiguously. In pharmacies, the medicine could be purchased for 1850 rubles for four 15 ml bottles. But in June 2017, the Ministry of Health of the Russian Federation excluded Colme from the state register at the request of the drug manufacturer.
Thus, drops of “Kolme” became unavailable in Russian pharmacies, no plans to return to the domestic market in the near future. The medicine is brought to Russia privately from Spain (country of origin) or other countries where its sale is permitted. It is also known that in Belarus and Ukraine, the drug will also disappear in the near future.
In connection with this fact, it is worth looking at other drugs for the treatment of alcoholism. A suitable drug will be recommended by a narcologist.
Analogs of drops "Colme"
Replace "Colma" can drugs with disulfiram. The range of such drugs is quite wide. It is widely used for the treatment of chronic alcohol dependence and relapse, for example, "Lidevin." The product is positioned as a complete analogue to Colma, but its composition is completely different, just like the action of the active substance. Similar drugs: Antabus, Disulfiram.
For the treatment of alcoholism, ProProTen-100 is also used in the form of drops or lozenges (they are difficult to find in pharmacies). The medicine reduces the craving for alcohol, has an anti-alcohol effect on the body and reduces the likelihood of relapse. The drug is also used to alleviate disorders that occurred as a result of addiction, namely increased nervousness, anxiety, sleep disturbances, anxiety, and a decrease in the emotional background.
Drops "ProProTen-100" are available in 25 ml bottles, dispensed from pharmacies without a prescription. Take the medicine in ten drops, diluted in a tablespoon of clean water. For a hangover, take the drug in this dosage every thirty minutes for the first two hours, then (the next eight to ten hours) - ten drops per hour. To prevent breakdowns, ten drops of ProProTen-100 are taken once or twice a day for two to three months. When drinking alcohol, you need to drink an additional ten drops of the drug twice - in the morning and at night.
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