Angina pectoris is a disease characterized by a feeling of discomfort and discomfort that occurs behind the sternum. Experts say that such pain occurs unexpectedly during stress, after a meal or during physical exertion. Usually it gives to the lower jaw, neck, subscapular region, left shoulder and lasts for an hour. This condition disappears immediately after the cessation of stress or taking special medications.
Very often with angina pectoris, patients take the Molsidomin medication. Its analogs, instructions, indications and properties are described below.
Form, packaging, composition
The drug "Molsidomin LF" goes on sale in the form of orange or pink tablets of a flat and round shape with beveled edges. They contain 2 or 4 mg of molsidomine. In addition, the composition of the medicine includes auxiliary components (povidone K-25, potato starch, sucrose, food coloring, lactose, magnesium stearate).
This drug is sold in blisters that are placed in cardboard packaging.
Drug features
The medication in question is referred to as vasodilators, that is, drugs that dilate blood vessels. After taking it, the venous flow to the heart muscle decreases, as well as the tone of the venules. This helps reduce pulmonary pressure and myocardial tension.
Operating principle
How do Molsidomin tablets work? The instruction for use states that the effect of this medication is due to the action of the metabolite of its active substance, linsidomine. This element affects the smooth muscles of blood vessels, reducing their tone. In addition, it exhibits antiaggregant properties.
As soon as the tone of smooth muscles decreases, the volume of the vascular bed increases and the pressure in the heart ventricles decreases. As a result of this effect, the load on the heart and its oxygen demand are reduced.
It is impossible not to say that under the influence of molsidomine spasms of the coronary arteries decrease and their branches expand. Thus, the blood supply to the heart is significantly improved.
Drug kinetics
The drug Molsidomin, the price of which is indicated below, is absorbed in the digestive tract by 90%. Its bioavailability is 65%, and only 11% binds to plasma proteins.
The drug begins to manifest its effect after 20 minutes and lasts about 6 hours. After another 30-50 minutes, the concentration of the drug in the blood reaches its maximum.
Molsidomin tablets, the instructions for use of which are indicated below, are transformed in the liver. This happens through an enzymatic route. The main substance of the drug is converted to sydnonimine 1, which subsequently turns into linsidomine. It is this metabolite that provides the effect of the drug.
The medication in question is excreted from the body with urine within one and a half to two hours.
Indications
Molsidomin tablets are indicated for use in the following cases:
- prevention of angina attacks;
- pulmonary heart disease therapy;
- elimination of already developed angina attacks.
Bans on admission
The medication in question cannot be taken with the following pathologies and conditions:
- severe hypotension;
- lactation period;
- glaucoma;
- pregnancy;
- myocardial infarction (in the acute phase), especially with low blood pressure;
- cardiogenic shock;
- disorders of carbohydrate metabolism.
The use of the medication for acute myocardial infarction is permissible only with regular monitoring by a doctor.
Molsidomin tablets: instructions for use
Dosage and use of this drug depend on the available indications.
For the prevention of angina attacks, the drug is prescribed 4-12 mg per day. It is taken orally after a meal.
When using the medication for therapeutic purposes, it is prescribed 1-2 mg daily in 4-6 doses. If required, the dosage is increased to 2-4 mg. At the same time, the number of receptions is reduced to 2-3 times a day.
To eliminate an already developed attack of angina pector should be placed under the tongue.
Side effects
Precautions when taking the drug in question should be observed by all patients. This is due to the fact that during treatment a person may manifest the following undesirable effects:
- nausea;
- lowering blood pressure, especially with a sharp rise;
- headaches that develop at the very beginning of treatment;
- redness of the skin of the face;
- rash (appears very rarely).
Precautionary measures
In a usual situation, the hypotensive effect of this drug is weakly expressed. However, with its combination with other vasodilators or during therapy, people with reduced circulating blood volume or arterial hypotension should be especially careful.
Elderly people with impaired liver or kidney function are required to prescribe reduced doses of the drug.
Cost and replacement funds
Now you know how to take Molsidomin tablets. Instructions for use of the drug were presented above.
The cost of this medication is 90-100 rubles per package. If required, it can be replaced with drugs such as Dilacid or Sidnofarm.
Consumer reviews
There are many reviews of Molsidomin tablets. In most of them, consumers claim that this drug in a short time helps to eliminate the severity of the clinical manifestations of angina pectoris and heart failure. Also, many patients are pleased with the low cost of this medicine and its availability in all pharmacies. Only negative reactions are considered to be disadvantages, but the same can be said of most medicines.