Texamen - NSAIDs, representative of oxycams. The drug eliminates inflammatory processes and pain, is able to reduce fever. Below is a description of the drug "Texamen", analogues, instructions for use.
Release form, composition
The drug can be purchased in coated tablets and in the form of a solution for injection. The active ingredient is tenoxicam (20 mg). Excipients include pregelatinized starch, magnesium stearate, talc. Lactose is also used as an additional ingredient. The tablet shell consists of yellow iron oxide, polyethylene glycol 400, titanium dioxide, hydroxypropyl methylcellulose.
Pharmacological properties of the drug
Both the original drug and the Texamena analog selected by the doctor will allow you to get rid of pain, inflammation and heat, and prevent platelet aggregation. The action of the drug is based on the suppression of the activity of COX-1 and COX-2 isoenzymes. Thanks to the use of the drug, the production of prostaglandins slows down in the body, and less leukocytes accumulate in the inflamed area. The anti-inflammatory effect is observed approximately one week after the start of treatment. The effect of the drug persists for a long time.
Absorption occurs quickly, the drug is completely absorbed, but this process proceeds more slowly if the tablet is taken before meals. Bioavailability is 100%, almost complete communication with proteins that are present in blood plasma is performed. The maximum concentration of the drug is determined 120 minutes after its use. Half-life occurs over 72 hours. The components of Texamena enter the synovial fluid. The drug has the ability to pass through histohematological barriers. Metabolism is carried out in the liver; as a result of hydroxylation, 5-hydroxytenoxicam is formed. Most of the drug is excreted by the kidneys (inactive metabolites), the rest - by the liver (bile).
Indications for use
Both the original and the Texamena analogue (injections, tablets) are prescribed to relieve pain, which is slightly or moderately expressed:
- headache, toothache;
- skin lesions due to burns;
- damage due to traumatic effects;
- algodismenorea;
- migraine;
- neuralgia;
- myalgia;
- arthralgia.
The drug is indicated for tendovaginitis, bursitis, osteoarthritis, rheumatoid arthritis. "Texamen" treat ankylosing spondylitis. It is used to eliminate articular syndrome with gout during an exacerbation.
Contraindications
This list includes hypersensitivity to the components of the drug, children's age (less than 18 years), bearing a child, breastfeeding. The Texamena analogue is prescribed when treatment with the original drug is unacceptable. Texamen is not used in the following cases:
- lesions of the hematopoietic system;
- pathological conditions of the vestibular apparatus;
- severe gastritis;
- gastrointestinal tract lesions - bleeding, erosive-ulcerative lesions (pathological conditions in history are also a contraindication to treatment with Texamen);
- hearing impairment;
- hypocoagulation;
- lack of glucose-6-phosphate dehydrogenase;
- hemophilia;
- triad "aspirin";
- renal and liver failure.
Constant monitoring of the state of health is required in the treatment of elderly patients, patients with diabetes mellitus, hypertension, a tendency to edema, and heart failure.
Texamen treatment
Both the original and the Texamena analogue (injections, tablets) are used to determine the individual dose for each patient. Basically, one tablet is taken orally. The medication is a single dose and should be carried out daily at the same time after eating. With prolonged use of the drug, 10 mg of the drug is required for daily use. Patients with gout in case of an acute attack are recommended to take 40 mg of the drug for the first two days, the rest of the time (five days) - one tablet per day.
Side effects
Undesirable reactions of the body can occur from the nervous, cardiovascular and digestive systems. Possible negative reactions of hematopoietic organs to the drug used, for example, an analog of Texamena. In rare cases, an allergy develops, which is manifested by Lyell, Stevens-Johnson syndromes , Quincke's edema, urticaria, itching, skin rash. Sometimes some laboratory parameters change. Among other side effects - edematous syndrome, excessive sweating, impaired renal function, bronchospasm. In case of an overdose, treatment is performed aimed at eliminating its symptoms.
special instructions
During therapy, control of peripheral blood is required, it is also necessary to regularly check the condition of the kidneys, liver, determine the level of glucose in the blood, prothrombin index. Sometimes the doctor may prescribe an analogue of Texamena.
In cases where it is necessary to determine 17-ketosteroids, treatment is interrupted for a while. The drug should be discontinued two days before the study. Its abolition is required before performing surgical procedures (a few days before the operation).
During therapy, it is not recommended to carry out potentially dangerous activities, the implementation of which requires increased attention and quick psychomotor reactions.
Taking the drug is associated with a risk of water and sodium retention, their prolonged excretion from the body. This result is possible with the simultaneous use of Texamen and diuretics for the treatment of patients with heart failure and hypertension.
Patients with kidney diseases may have a history of nephrotic syndrome, papillary necrosis, interstitial nephritis.
The cost of the drug, analogues, reviews
The Texamena analogue is cheaper than the original product. The solution can be purchased for 205-215 rubles., The approximate cost of tablets is 270-300 rubles. Analogues with an identical active substance and analogs that have a similar effect are produced. There is a foreign substitute for Tenikam, this drug is based on the same active substance as Texamen. You can buy a domestic analogue of Texamena. Which one to choose should be decided by the doctor.
"Nise" is also a foreign-made medicine, it can replace the original medicine. In the composition of this analogue there is another active substance, but the effect of the medication has a similar effect to Texamena. With its help, it is possible to forget about pain for a long time and quickly eliminate the inflammatory process.
The Texamena analogue is no worse than imported. "Texamen" has a large number of substitutes, the choice of a suitable tool is carried out in conjunction with the doctor. It can be completely replaced with Naproxen, Polcortolon, Flamax or Naklofen. Perhaps treatment with the use of "Endoxan", "Polyoxidonium", "Prednisolone", "Nalgesin." The use of Feloran is allowed as an analogue.
The analogue of Texamena is Russian - Diclofenac. This is a fairly well-known substitute for the original drug. As a result of its application, a similar therapeutic effect is achieved. "Diclofenac" has a low cost, therefore, is an affordable tool, however, treatment with such a medicine can adversely affect the condition of the stomach. For this reason, doctors do not prescribe it to patients who have problems with the gastrointestinal tract. Diclofenac is a reliable analogue, but not for everyone.
According to reviews, many Texamen are prescribed to eliminate the pain syndrome. Patient reviews are positive, which is associated with the drug performing its tasks. Side effects usually do not develop.