The drug "Uniderm" instructions for use relates to the group of glucocorticosteroids for local use. The active component of the drug is mometasone, it produces antipruritic, anti-inflammatory, antiexudative effects.
Pharmacological properties
A synthetic glucocorticosteroid induces the release of phospholipase-inhibiting A2 proteins known as lipocortins. By stopping the release of arachidonic acid, they control the synthesis of leukotrienes and prostaglandins.
Experts indicate a slight absorption of the Uniderm medication. The instruction indicates that eight hours after applying the cream to the skin (without using an occlusive dressing), only 0.4 percent of the drug is found in the systemic circulation.
Indications for appointment
The drug is used in case of inflammatory manifestations and itching with dermatoses that can be treated with glucocorticosteroids, including with atopic dermatitis, psoriasis.
Dosage form and composition
The Uniderm medication is available in the form of a cream of almost white or completely white color, intended for external use. The medicine is packaged in aluminum tubes of 15 or 30 grams, and they, in turn, are placed in cardboard boxes. In one gram of cream, the active ingredient - mometasone furoate - is contained in a mass of 1 milligram. Minor components are cetostearyl alcohol, titanium dioxide, white wax, diluted phosphoric acid, hexylene glycol, white petrolatum, glyceryl monostearate, propylene glycol, macrogol 20 cetyl stearate, purified water, aluminum starch, octenyl succinate.
Cream "Uniderm". Analogs
Generics of the drug are drugs "Nazonex", "Momat", "Asmanex", "Elokom". All of them have a similar spectrum of activity and are used in the treatment of dermatoses. Prednisolone ointment can also be used for this purpose.
"Uniderm": the use of medication, dosage
As already noted, the cream is intended for local use. It should be applied to the affected skin once a day. The duration of therapy should be determined by the doctor, based on the characteristics of the patient (tolerance, severity of side effects).
The use of Uniderm for children
Reviews of many parents who used this medication in the treatment of children report its good tolerance and effectiveness. However, it should be noted that the safety of the cream when used in children for more than six weeks has not been studied. Since in babies the value of the ratio of weight to body surface area is greater than in adults, they are more exposed to the risk of suppressing the normal functioning of the hypothalamic-pituitary-adrenal system and the occurrence of Cushing's syndrome in the case of any local glucocorticosteroids. Based on this, it is impossible to deny the possibility of developmental and growth disorders during long-term treatment with Uniderm cream. The instruction draws the attention of parents to the fact that the dose of medication received by children should be minimal, but at the same time sufficient to achieve a therapeutic effect. The duration of a therapeutic course for babies from six months to two years should not be more than five days.
Side effects
In most cases, against the background of the use of the drug, adverse effects do not occur. Patients positively assess the tolerance of the Uniderm drug. Reviews of individuals nevertheless contain information about negative manifestations. So, it is reported about the occurrence of burning, itching, dry skin, the appearance of a rash. The instruction also notes among the possible side effects hypertrichosis, allergic contact and perioral dermatitis, folliculitis, hypopigmentation, maceration, signs of skin atrophy, prickly heat, and secondary infection. In very rare cases, pustules, papules can form.
If you apply the cream to treat large areas of the skin or under an occlusive dressing, negative effects may develop that are characteristic of all glucocorticosteroids of systemic activity, such as adrenal insufficiency, hypercorticism syndrome.
Contraindications
In the case of personal hypersensitivity to any of the components contained in the composition or to glucocorticosteroid preparations in general, it is necessary to abandon the use of the Uniderm drug. The instruction also prohibits the use of cream for perioral dermatitis, rosacea, skin infections, syphilis, tuberculosis. Medication is contraindicated in children under six months of age. With extreme caution, it is necessary to apply the drug under occlusive dressings, in the area of the folds and on the skin of the face, as well as on extensive surfaces of the body. Do not allow contact with eyes.
Pregnancy and lactation
The safety of using the cream during these periods has not been studied. However, glucocorticosteroids are known to be able to cross the placental barrier. To avoid negative effects on the development of the fetus, during pregnancy to use the medicine "Uniderm" instruction recommends in small doses and for a short time. Among other things, glucocorticosteroids are excreted together with breast milk. Therefore, you need to stop breastfeeding if you need to use the cream in significant quantities or for a long period.
Overdose
With excessive and frequent application of the drug to the skin surfaces, inhibition of the hypothalamic-pituitary-adrenal system can occur, including the development of secondary adrenal insufficiency. In this case, symptomatic treatment is required, if necessary, an electrolyte imbalance correction should be performed or the medication should be canceled (with long-term therapy, withdrawal should be done gradually).
special instructions
Propylene glycol contained in the Uniderm cream at the application site can cause irritation. In such a situation, you need to stop using the drug and consult a doctor for the appointment of appropriate treatment. It must be borne in mind that glucocorticosteroids can change the manifestations of certain skin diseases, and this can lead to difficulties in making the correct diagnosis. The use of glucocorticosteroids can also cause slower healing of wounds.
If you carry out therapy with Uniderm medicine for a long time, and then abruptly stop treatment, a rebound syndrome may develop , which is found in the form of dermatitis, accompanied by a burning sensation and severe reddening of the skin. Therefore, the abolition of the drug in this case should be done gradually, for example, first switch to the intermittent therapy regimen, and then completely stop using the cream.
Holidays from pharmacies. Price
To purchase the Uniderm medication in a pharmacy, you will need to provide a prescription from a doctor. The cost of a tube of cream weighing 15 grams averages 140-150 rubles. The purchase of a 30-gram tube will cost about 260 rubles.
Shelf life. Storage conditions
The drug is suitable for use for two years. It should be stored in a place protected from the rays of the sun at a temperature of 15-25 degrees Celsius.