"Ultrafastin Forte" is a derivative of phenylpropionic acid, and it is classified as a non-steroid drug. Next, we consider in detail the instructions for this drug. In addition, we find out in what quantity, according to the manual, you can take the presented medical product for the relief of a painful condition. At the end of the article we will get acquainted with customer reviews. So, let's start by studying the composition of this medicine.
Composition "Ultrafastin Forte"
Each pill contains an active ingredient called ketoprofen in an amount of 100 milligrams. Microcrystalline cellulose in combination with silicon dioxide, crospovidone and magnesium stearate are excipients. The composition of the membrane includes hypromellose along with lactose monohydrate, triacetin, titanium dioxide, macrogol, iron oxide and so on. The product is released in the form of light yellow biconvex tablets.
Instructions for "Ultrafastin Forte" are available in each pack.
Pharmacological effects
Ketoprofen (active component) is classified as a non-steroid drug. The substance has anti-inflammatory, analgesic, antipyretic and anti-aggregation properties. The mechanism of its effect is due to the inhibition of cyclooxygenase, which is an enzyme responsible for the synthesis of prostaglandins. The active substance also acts as an antagonist of bradykinin. It inhibits the synthesis of leukotrienes, platelet aggregation decreases, and a stabilizing effect on the lysosomal membranes occurs.
Ketoprofen can be well absorbed from the digestive system. After internal administration in the form of tablets of forte, the maximum concentration in the blood plasma is reached after about ninety minutes. Bioavailability is approximately eighty percent, food does not affect this indicator.
Ketoprofen ninety-nine percent binds to plasma proteins, mainly with albumin. The substance penetrates the joint cavity and synovial fluid. It also enters the cerebrospinal composition and through the placental barrier. Against the background of repeated administration, the active component is not cumulated in the human body. The half-life is about two hours.
Ketoprofen, as a rule, is transformed in the liver, mainly through conjugation with glucuronic acid and partly due to hydroxylation. The metabolites of the drug are excreted in the urine and are pharmacologically inactive. After oral administration, approximately seventy-five percent of the dosage is excreted in urine after five days.
Indications
The considered agent "Ultrafastin Forte" is used in the following cases:
- In the complex treatment of inflammatory, metabolic and degenerative joint diseases with rheumatoid arthritis, osteoarthritis, spondylitis and so on.
- Against the background of extra-articular rheumatism with tenosynovitis, bursitis, capsule and more.
- As part of the relief of pain of various etiologies, from mild to moderate in intensity with headache, migraine, algodismenorea, and renal colic.
- In the case of neuralgia and myalgia of different genesis, as well as with radiculitis.
- Against the background of hyperthermia, regardless of genesis.
Contraindications
As the instructions for Ultrafastin Forte tablets indicate, it is forbidden to take this medicine in the following situations:
- With increased individual sensitivity to ketoprofen or some auxiliary component of the drug.
- Against the background of the incompatibility of the body with non-steroidal anti-inflammatory drugs, for example, with acetylsalicylic acid, including with aspirin asthma.
- In the case of an active phase or recurrent peptic ulcer of the stomach or intestines.
- With ulcerative colitis, which is at the stage of exacerbation, and, in addition, with Crohn's disease and diverticulitis.
- Against the background of the state after coronary artery bypass grafting.
- In the case of confirmed hyperkalemia.
- With severe kidney and liver failure.
- In case of problems with the heart system.
- Against the background of active bleeding, for example, from the structure of the digestive system or blood vessels of the brain.
- In children under the age of fifteen.
During pregnancy
The considered medicinal product "Ultrafastin Forte" can be used in the first two trimesters only as prescribed by the doctor. In the last period of gestation, it is strictly contraindicated. Do not recommend the use of medication during breastfeeding.
Instructions and dosage
As part of a long symptomatic treatment, as a rule, two Ultrafastin Forte tablets are used per day, in two doses or once. Against the background of symptomatic short-term therapy, one thing is taken three times. The medicine should be taken orally, with food, washed down with water. Tablets must be swallowed whole, they can not be chewed.
The dosage of "Ultrafastin Forte" is important to strictly adhere to.
Side effect
Unfortunately, this medicine often provokes various undesirable reactions. For example, a violation of the digestive tract is possible, which will manifest itself in the form of nausea, vomiting, diarrhea, constipation, dyspepsia, heartburn and abdominal pain. Gastritis is not excluded along with stomatitis, less often colitis and bleeding, and in exceptional cases intestinal perforation is likely.
Sometimes a hypersensitivity reaction is observed in the form of rashes, itching, erythema and increased symptoms of chronic urticaria. The respiratory system can respond with suffocation, the possibility of asthma attacks (especially in patients with existing hypersensitivity to various non-steroidal drugs). It is extremely rare to fear anaphylactic reactions and angioedema.
Violations of the functioning of the nervous system in the form of headache, dizziness, drowsiness, depression are possible, convulsions rarely appear. The skin sometimes reacts with photosensitization, alopecia, and in exceptional cases, patients have Johnson and Lyell syndrome. Possible failure of the kidneys and urinary canals. Usually this appears in organ failure, especially in individuals with impaired function and in dehydrated patients. It is extremely rare to expect interstitial nephritis or nephrotic syndrome
There may be a malfunction from the lymphatic system, that is, the development of thrombocytopenia, anemia caused by chronic bleeding, leukopenia with agranulocytosis is rarely observed. An increase in the activity of transaminases is not excluded, hepatitis rarely occurs. Against the background of treatment with this drug, edema, hypertension and heart failure are sometimes reported. Other disorders include blurred vision and hearing problems (tinnitus).
Overdose
According to the instructions for use with Ultrafastin Forte, with such a disorder, patients may experience symptoms in the form of headache, drowsiness, nausea, vomiting, diarrhea and abdominal pain. In case of an overdose of a high amount of ketoprofen, arterial or arterial hypertension may occur along with difficulties in breathing, its delay, and bleeding from the digestive system.
With a strong overdose, additional symptoms appear:
- changes in blood pressure, it can sharply decrease or increase;
- depression of respiratory function;
- impaired consciousness;
- gastrointestinal bleeding;
- cramps
- acute renal failure;
- coma.
If no more than an hour has passed after taking the medicine, you need to drink activated charcoal. Overdose treatment should be aimed at restoring the proper functioning of the body systems.
Taking the drug in this case will need to be stopped immediately and consult a doctor immediately. There is no specific antidote to the medication. Therapy is symptomatic.
Features of the use of this drug
For people suffering from chronic rhinitis, bronchial asthma and sinusitis, as well as nasal polyposis, there is a high risk of developing an allergy to acetylsalicylic acid and other drugs from the NSAID category. Great care should be taken for people who have had a history of digestive system disorders.
The risks of bleeding are usually increased in elderly patients, people with low body weight, and, in addition, in patients suffering from impaired platelet function and those taking anticoagulants or inhibitors. “Ultrafastin Forte” however, like other medicines from this series, can mask the symptoms of developing infectious pathology. With caution, the drug should be used by persons with increased sensitivity to sunlight or a history of phototoxicity.
In people of advanced age, as well as those who suffer from heart failure or impaired liver function and water metabolism problems (for example, dehydration due to the use of diuretics), the active component of the drug can impair renal function due to inhibition of the synthesis of prostaglandins.
Among patients with heart failure, especially in old age, as a result of sodium and fluid retention in the body, an increase in undesirable effects can be observed. People with a diseased liver are shown careful observation by a doctor (it is necessary to periodically monitor the activity of transaminases) and individual selection of the dosage of the drug product in question is important.
It is recommended that Ultrafastin Forte be prescribed with great care to elderly people who have impaired renal and hepatic function. The use of this medication can adversely affect reproductive functions in women and is not recommended for women who are planning a pregnancy. In patients who can not conceive or undergo examination due to infertility, the use of this substance should be discontinued.
It is worth noting that the use of the drug in question in the minimum effective doses for the shortest time necessary to relieve symptoms, reduces the risks of unwanted effects. The described medicinal product is forbidden to be prescribed to patients who have rare hereditary galactose intolerance, lactase deficiency or galactose malabsorption syndrome. This medication is also prescribed with caution to people who suffer from hypertension and heart disease, which is accompanied by a delay in the body fluid. As a rule, monitoring of pressure is recommended, especially among patients with heart and vascular diseases.
The use of "Ultrafastin Forte" should be careful.
Precautions
There is currently no information on the negative impact of the described “Ultrafastin forte” in recommended doses on the ability to drive a car and work with mechanisms. True, when using this drug, great caution should be exercised by persons whose activities require psychomotor rapid reactions (driving a car, etc.).
Analogs of Ultrafastin Forte
Among the medicines that may replace the product we are describing, if necessary, the following drugs should be mentioned: “Valusal” along with “Ketonal” in the form of gel, capsules, cream, injections and “Ketonal-retard”. Now let's move on to considering the opinions of consumers and find out what they think about this pharmaceutical product.
Reviews
It is better to get acquainted in advance with reviews about Ultrafastin Forte tablets.
Patients leave different comments about the drug on the Internet. Among the positive reviews, it is noted that this medication is very effective in the framework of the complex treatment of inflammatory, metabolic and degenerative joint pathologies. It is often used for rheumatoid arthritis, osteoarthrosis, spondylitis and so on. Thus, people write that this medicine relieves pain discomfort well and allows patients to feel much better.
As for negative reviews, they also occur, and mainly consumers leave complaints about the frequent side effects that are observed during therapy with these pills. For example, it is reported that very often the digestive system suffers from the medication in patients, which manifests itself in the form of vomiting, diarrhea, or constipation. Also, the drug has a considerable list of contraindications, which makes it not convenient to use, since it is not suitable for everyone.
We reviewed the instructions for use with Ultrafastin Forte tablets.