Today we will tell you about how Hypothiazide helps? Also in the materials of this article will be presented instructions for the use of this drug, consumer reviews, its release form, properties and so on.
Description of the drug, form, packaging and composition
What helps Hypothiazide? Before answering the question, it is necessary to tell in what form this drug goes to pharmacies.
"Hypothiazide" is available in the form of white tablets (may have a grayish tint). They are round and flat in shape, at risk on one side and engraved “H” on the other.
The active element of this drug is the substance hydrochlorothiazide. Also, its composition includes auxiliary elements in the form of magnesium stearate, lactose monohydrate, talc, gelatin and corn starch.
On sale, this tool comes in blisters that are packaged in cardboard boxes.
Pharmacological action
What is the medicine "Hypothiazide"? What does this medicine help from?
According to the instructions, the drug in question is a diuretic. Its primary mechanism of action is an increase in diuresis by inhibiting the reabsorption of chlorine and sodium ions in the initial region of the renal tubules. This effect leads to increased excretion of chlorine, sodium and, as a result, water.
It should also be noted that after taking the medication mentioned, the excretion of other electrolytes increases, and more specifically, potassium and magnesium.
At high therapeutic dosages, the natriuretic and diuretic effects of this drug are the same.
Diuresis and natriuresis occur within 120 minutes and reach a maximum after 4 hours.
It should also be noted that this medication reduces the activity of carbonic anhydrase by increasing the excretion of bicarbonate ions. However, this effect of the drug is weak and does not affect the pH of urine.
The active substance "Hypothiazide" has antihypertensive properties. It is impossible not to say that the drug in question does not affect normal blood pressure.
Kinetics of medication
Is the medicine “Hypothiazide” absorbed? Instructions, a description of the drug report that hydrochlorothiazide is not completely, but very quickly absorbed from the digestive system. This effect lasts for 6-12 hours.
When taking the drug inside at a dosage of 100 mg, its peak plasma concentration is reached after 2.5 hours.
Communication with plasma proteins is 40%.
According to experts, hydrochlorothiazide is excreted along with breast milk and crosses the placental barrier.
The excretion of this drug is carried out by the kidneys within 6 hours.
Medication: "Hypothiazide": what helps?
This remedy is prescribed for:
- prevention of the formation of stones in the urinary tract in individuals predisposed to this disease (in order to reduce hypercalciuria);
- arterial hypertension (for monotherapy and in combination with other antihypertensive drugs) ;
- control of polyuria (mainly with diabetes insipidus nephrogenic diabetes);
- edematous syndrome of various origins (premenstrual tension syndrome, nephrotic syndrome, chronic renal failure, acute glomerulonephritis, treatment with corticosteroids, chronic heart failure, portal hypertension).
Contraindications
About what “Hypothiazide” helps from, we described above. You should also know about the contraindications of this tool. These include:
- children's age up to three years;
- severe renal failure;
- Anuria
- severe liver failure;
- Addison's disease;
- diabetes mellitus difficult to control;
- refractory hypokalemia, hyponatremia, hypercalcemia;
- hypersensitivity to drug elements and sulfonamide derivatives.
With extreme caution, this tool should be used for coronary heart disease, hypokalemia, cirrhosis, hyponatremia, gout, hypercalcemia, the use of cardiac glycosides, lactose intolerance and in the elderly.
The drug "Hypothiazide": instructions for use
Reviews, analogues of the drug in question are presented at the end of the article.
Tablets should be taken after a meal. Their dose is selected during treatment, individually.
Initial dosage of the drug for adults:
- Syndrome of premenstrual tension: taking the medicine begins with the appearance of the first signs before the onset of menstruation (in the amount of 25 mg once a day).
- Edema syndrome of various origin: 25-100 mg once a day or once every two days. In severe cases, the drug is prescribed 200 mg.
- Arterial hypertension: 25-50 mg once a day. The therapeutic effect of this medication is manifested within 4 days.
- Nephrogenic diabetes insipidus: 50-150 mg per day (in several doses).
As for children, for them the drug in question is prescribed taking into account weight. The daily dosage is 1-2 mg / kg.
Side effects
Now you know how Hypothiazide helps. The following adverse reactions may develop while taking this medication:
- anorexia, dry mouth, muscle cramps, diarrhea;
- muscle pain, constipation, fatigue, cholecystitis, weakness, cholestatic jaundice;
- lethargy, pancreatitis, thirst, sialadenitis;
- arrhythmia, aplastic anemia, vasculitis, thrombocytopenia, headache, leukopenia;
- dizziness, hemolytic anemia, functional disorders of the kidneys, agranulocytosis and others.
Analogs and reviews about the drug "Hypothiazide"
Reviews on "Hypothiazide" report that it is an effective and fast-acting diuretic. Taking these pills prevents the formation of stones in the urinary tract, reduces blood pressure and eliminates edema of various origins.
The disadvantages of this medication include a large number of adverse reactions.
The analogous means of this drug are: “Hydrochlorothiazide”, “Hydrochlorothiazide-SAR”, “Dichlothiazide”, “Hydrochlorothiazide-Verte” and others.