The drug is a lyophilizate for the manufacture of a solution for intramuscular administration, usually the powder is white or light yellow; a thinner is a colorless transparent liquid. The prepared solution will be transparent or acquire a light yellow tint.
Indications for use
Indications for "Immunoro Kedrion", reviews of which are mostly positive, are as follows:
- Prevention of negative Rh conflict in girls who are not sensitized to the Rho (D) antigen during their first pregnancy and the birth of a Rh-positive baby if the blood matches the mother's ABO system.
- With artificial interruption, when a woman during pregnancy has a Rhesus factor negative, and her husband's blood is Rh positive.
Contraindications
Contraindications to the drug look like this:
- Hypersensitivity to the components of the "Immunoro Cedrion".
- Pregnant women with a negative rhesus sensitized to an antigen in which blood serum Rh antibodies are detected.
- Do not take newborns.
Use during pregnancy and lactation
"Immunoro Kedrion", reviews of which are positive, is used during pregnancy and within three days after childbirth. There were no cases of any harmful effects on the baby during pregnancy or lactation.
Side effects
Sometimes painful sensations appear at the injection site, but this can be avoided. It is necessary to administer the drug in small volumes - less than 5 milliliters in several different areas.
Judging by the reviews, "Immunoro Cedrion" can provoke the appearance of the following side effects:
- rarely - fever, dermatological reactions, trembling;
- extremely rarely - dyspeptic symptoms (vomiting and nausea), decreased blood pressure, tachycardia, rash or other allergic reactions.
Dosage according to the instructions for use "Immunoro Cedrion"
2 hours before the injection, the ampoules with the drug should be at room temperature. The product in the opened bottle is not subject to storage, it must be disposed of. The drug is not allowed to be administered intravenously.
Intramuscularly, the medicine is prescribed (one-time): a woman in labor - during the first two to three days after labor, with artificial termination of pregnancy - after completion of the procedure.
The dose of the drug is prescribed individually by a doctor, since it all depends on how much blood of the unborn child is in the bloodstream of a pregnant woman. In 1 dose of Immunoro Kedriona (300 mcg) there is a sufficient number of antibodies to avoid sensitization to the Rh factor (if the volume of red blood cells that have entered the bloodstream of the expectant mother is not higher than 15 ml).
Dose increase
In case there is a suspicion that a larger number of red blood cells got into the bloodstream of a pregnant woman, it is necessary to calculate the fetal red blood cells using proven laboratory technology (for example, the converted Kleichauer and Betka acid acid wash-stain method) in order to determine the required dose of the drug. The calculated volume of fetal red blood cells that enter the mother’s bloodstream is divided by 15 (calculation is carried out in ml) and the number of doses of the substance to be administered is obtained. If during the calculation of the dose a non-integer number is obtained, it is necessary to round the number of doses up (for example, when receiving result 1.4 it is necessary to enter 2 doses of the substance).
For prophylaxis in the prenatal period, it is necessary to introduce another dose of the drug, it must be done at about the 28th week of pregnancy. Further, it is absolutely necessary to introduce one more, it is advisable to do this within two to three days after the birth, but only if the newborn baby is Rh-positive.
After a spontaneous or artificial abortion, getting rid of an ectopic pregnancy for a period of more than three months, it is recommended to introduce a dose (300 mcg) of the substance (or more if there is a suspicion that more than 15 ml of fetal red blood cells have entered the bloodstream).
If the pregnancy was interrupted for less than 13 weeks, it is recommended to introduce a mini-dose (approximately 50 mcg) once. After performing amniocentesis, or in the fourth to fifth month, or during the third trimester, or when injuring the abdominal organs during the second or third trimester, it is recommended to introduce one full dose of the drug. If more than 15 ml of a child’s red blood cells have entered the woman’s blood, the dose should be determined based on the calculation presented above.
In case organ damage, amniocentesis or any other unfavorable circumstance requires the introduction of a substance at a 4-month gestation period, it will be necessary to make a second injection for a period of six months.
To ensure the safety of the expectant mother and baby throughout pregnancy, you should regularly do tests, check the number of Rh-positive red blood cells of the fetus.
If the baby was born Rh-positive, then the mother must enter "Immunoro Kedrion" within 2-3 days after the birth.
If a woman gave birth within a month after injection of a medication, then the “postpartum” dose is not allowed to be administered, but only if less than 15 ml of Rh-positive red blood cells have entered the mother’s blood.
Judging by the reviews of "Immunoro Kedrione", the drug helped many mothers not only to endure normally, but also to maintain pregnancy. Therefore, you should not refuse this medicine if it is prescribed by a doctor, because the expected benefits for the mother and child are much higher than the possible risks.