How long does Nimesil begin to act? Consider further in the article.
Nimesil in powder form is part of the group of non-steroidal anti-inflammatory drugs. It is a chemical derivative of sulfonanilides. The drug is taken as an anti-inflammatory agent in any variant of the manifestation of symptoms of the inflammation process.
Not everyone knows how to breed Nimesil powder according to the instructions for use.
Release form and composition
Nimesil is made in the form of a powder for the preparation of a suspension, which is intended for oral administration. The powder is light green, coarse-grained, with an orange smell. The main active substance of the drug is nimesulide. Its content per sachet with powder is 100 mg. Auxiliary components of the powder are sucrose, ketomacrogol, maltodextrin, anhydrous citric acid and orange flavoring.
The drug is packaged in 2 g foil bags. In one package there can be 9, 15 or 30 sachets.
How to take "Nimesil" - before or after a meal? About it below.
The properties
Nimesulide is a selective antagonist of cyclooxygenases-2, which have an inhibitory effect on its activity. In response to the formation and development of pathological processes in the form of inflammation, cyclooxygenase-2 provokes a reaction to convert arachidonic acid to prostaglandins, which are the main pathogens of the inflammatory reaction produced by the immune system.
A decrease in the number of prostaglandins provokes a decrease in the severity of inflammation, and also relieves pain and swelling of the tissues, eliminating blood stasis in the microvasculature.
The active ingredient when taking a suspension based on Nimesil is rapidly and effectively absorbed into the bloodstream. Nimesulide is evenly distributed throughout the tissues, providing a pronounced therapeutic effect. The active substance is metabolized in the liver through the production of inactive substances, which are subsequently excreted in the urine. Half-life of the drug from the body occurs approximately 6 hours after taking Nimesil.
How many Nimesil starts to act is interesting to many.
Indications
The suspension on the basis of Nimesil powder is taken to reduce the intensity of the inflammatory process, as well as to eliminate soreness in some diseases, including:
- Pain in the back, namely the lumbar, against the background of the inflammatory process.
- Pathologies of bone and muscle structures, including various injuries, tendonitis, sprain, subluxation and dislocation of joints, etc.
- Toothache.
- Pain in the head of various origins, including migraine in varying degrees of intensity of its manifestation.
- Soreness during menstrual bleeding.
At what age can Nimesil be taken?
From the age of 12 Nimesil has been used exclusively as symptomatic therapy for pain and inflammation. However, the cause of the symptoms does not resolve.
Mode of application
How to dilute Nimesil powder according to the instructions for use?
The drug is diluted to prepare a suspension intended for oral administration. The contents of one sachet of the drug is diluted in 100 ml of water. Take the suspension immediately after preparation, it is not recommended to store it. Before or after eating "Nimesil" drink? Suspension is better to use after eating.
The standard dosage of the drug is 100 mg of nimesulide twice a day. The duration of treatment with Nimesil should not exceed 15 days. As a rule, there is no need to adjust the dosage for adolescents, the elderly and patients with mild renal failure.
How long does Nimesil begin to act? The effect is noticeable after 15 minutes, up to half an hour. It is excreted in 3-6 hours.
How much to take "Nimesil"? 1 sachet every 12 hours is the usual dosage. Which is important, if the pain and inflammation are moderate, there is a slight ache and other symptoms.
The total duration of administration for most medicines in this group is 5-7 days.
Contraindications
Nimesil is contraindicated for use in the following diseases and conditions:
- Peptic ulcer, accompanied by a violation of the mucous membrane of the duodenum and stomach. This is due to the effect of nimesulide on prostaglandins, which, among other things, have a protective effect on the mucous membrane of the organs of the gastrointestinal tract.
- The patient has a history of bleeding in the gastrointestinal tract, including those caused by peptic ulcer.
- Chronic intestinal diseases of a non-infectious nature, accompanied by an inflammatory process and in the acute stage (for example, ulcerative colitis of a non-specific nature).
- A fever that provokes an increase in body temperature, especially with acute viral pathology, as well as bacterial infectious diseases.
- Allergic diseases, including a combination of bronchial asthma, polynosis and an individual reaction to acetylsalicylic acid, which is part of non-steroidal anti-inflammatory drugs.
- Severe hypersensitivity to acetylsalicylic acid, accompanied by bronchospasm, urticaria or inflammatory process on the nasal mucosa.
- The recovery period after surgery, including coronary artery bypass grafting.
- Diseases in the patient’s history due to hemorrhagic stroke of the brain, as well as a high probability of bleeding.
- Severe clotting disorders in severe form, including a decrease in hemostatic activity.
- Decreased heart activity of a pronounced nature against a background of severe organ failure.
- Combination with drugs that negatively affect the condition of the liver, namely hepatotoxic drugs.
- Severe liver and kidney failure.
- Drug or alcohol dependence in chronic form.
- Children under 12 years old.
- The period of gestation and breastfeeding.
- Intolerance to the components of the drug of an individual nature.
Reception with caution
There are also pathologies in which "Nimesil" adults should be taken with caution:
- Type 2 diabetes mellitus.
- Hypertension.
- Coronary heart disease.
- Diseases of the peripheral arteries.
- Smoking.
- Taking non-steroidal anti-inflammatory drugs that reduce blood coagulability, such as Heparin, Clopidogrel, etc., as well as hormonal glucocorticosteroids with anti-inflammatory effects.
Indications for the use of Nimesil powder must be strictly observed.
Adverse reactions
When taking a suspension made of Nimesil powder, the following undesirable reactions may appear from some organs and systems of the body:
- Digestive system: nausea with periodic vomiting, diarrhea, sometimes bloating, soreness in the abdomen, constipation, bleeding, accompanied by darkening and tarry texture of feces.
- The system of the heart and blood vessels: increased pressure in the arteries, tachycardia, accompanied by increased heart rate, hot flashes.
- Biliary system and liver: inflammation of the liver, hepatitis with a rapid course, accompanied by icteric syndrome, increased activity of liver transaminases, showing damage to organ cells, the so-called hepatocytes.
- Nervous system: headache, nervousness, dizziness, nightmares, a feeling of fear and anxiety.
- Respiratory system: shortness of breath, in rare cases, exacerbation of bronchial asthma.
- Urinary system: the appearance in the urine of blood impurities or hematuria, painful urination or dysuria.
- Sensory organs: impaired visual function.
- Blood and bone marrow: anemia, eosinophilia, thrombocytopenia and other changes in blood counts.
- Allergy: rash and itching of the skin, increased sweating, urticaria, anaphylactic shock, Quincke's edema rarely appear, etc. When the last symptoms appear, measures should be taken to provide emergency medical care, give antihistamines and call an ambulance.
Side effects and contraindications of Nimesil are described in detail in the instructions.
The appearance of the described symptoms while taking a suspension indicates intolerance to the components of the drug and the need for urgent withdrawal of this drug.
Special recommendations
Before you start taking Nimesil, you must carefully study the attached instructions for the drug. There are a number of recommendations for the proper use of the drug, namely:
- The active component of "Nimesil" is not combined with all drugs, so before you start taking it you must consult a doctor, be sure to notify a specialist about all the drugs that you are taking at the moment.
- When using the drug in an effective therapeutic dosage and subject to a short course of administration, the risk of side effects is significantly reduced.
- Moderate renal failure may require a reduction in the dosage of the drug taken.
- An additional component of the powder is sucrose, therefore, patients with diabetes should take the drug with extreme caution and conduct regular monitoring of blood sugar.
- "Nimesil" is forbidden to take simultaneously with other drugs from the category of non-steroidal anti-inflammatory drugs.
- The effect of the Nimesil components on the functioning of the central nervous system has not been fully studied, therefore, during treatment with the drug, work that requires an increased concentration of attention should not be performed, as well as driving a car.
"Nimesil" in bags should be dispensed in pharmacies by prescription. It should not be taken on its own.
Overdose
Do not exceed the dosage prescribed by a specialist. If Nimesil was taken in an abnormally large dosage, the following symptoms may occur:
- Vomiting
- Apathy.
- Drowsiness.
- Soreness in the abdomen.
- Bleeding in the gastrointestinal tract.
How to treat an overdose?
Treatment is carried out by eliminating the symptoms of an overdose. There is no specific antidote. First, the stomach and intestines are washed, then enterosorbents, Enterosgel, Smecta, or activated charcoal are prescribed. How long does Nimesil powder work, we explained above.
Analogs
Pharmacies are ready to offer quite a few drugs that are analogues of Nimesil. If you believe the reviews, the generics are identical to the original in properties and composition.
Nise, Nemulex, Nimesulide have the same active component as Nimesil, therefore, in principle, they are not able to act on the body otherwise. It should be noted that the concentration of the active substance in the listed preparations is identical.
No less effective analogues of Nimesil are:
- Aponil.
- "Kostral."
- "Mesulide."
- Nimulide.
- "Nimesan."
- "Niminka."
- "Aulin."
- Nimegesic, etc.
Many patients with headaches or toothaches often face the choice between Nimesil and Nise. The latter is an effective and cheaper drug, while Nise is produced both in powder form and in tablets. In small doses, it is permissible to give it even to children.
Nemulex and Nimesil are absolutely identical drugs. Only taste differs in them, since various auxiliary substances are included in their composition. Nemulex is cheaper, so many opt for it.
Reviews
In most cases, reviews about the use of Nimesil are positive. The drug in a short time and quite effectively eliminates the symptoms of inflammation and pain. In some cases, the drug is used as an antipyretic. Many note its prolonged effect, when a second dose may not be required.
The main disadvantage of the drug, patients note a negative effect on the digestive system. This is especially true for those who have a history of pathological processes in the stomach or intestines. For them, taking Nimesil can have unpleasant consequences precisely from the digestive system.
Conclusion
It should be borne in mind that nimesulide-based drugs are banned in many countries. However, experts argue that the drug in the form of a suspension is not as detrimental to the body as tablets, which dissolve directly in the digestive tract. In general, the drug is universally recognized as effective and is often prescribed by doctors.
We reviewed the detailed instructions for the drug. Now it’s clear how long Nimesil begins to act.