A man, despite the perfection and uniqueness of his body, very often suffers from pain. Joint, headache and muscle pain can deprive him of the joys of life for a long time. The medicine "Bol-Run", which will be discussed in this article, can help in eliminating pain of various etiologies. It is available in several dosage forms. In pharmacies you can find pills, ointments and creams of this brand.
There are several types of this drug that have differences in their constituent components. “Bol-Run” (tablets), for example, may have additional words in the names: “Neo” or “Premium”. What are the features of these dosage forms? Are there any differences in the dosage and method of taking the tablets? We’ll talk about this right now.
Composition of tablets "Bol-Run"
The drug "Bol-Run", the instructions for which will be discussed later, contains several components that act on inflammatory processes and pain receptors. It contains a non-steroidal anti-inflammatory component of paracetamol in an amount of 500 mg. Each tablet also contains 50 mg of diclofenac.
The composition of the Bol-Run Premium tablets, the instructions for use of which are not much different from the drugs of the same name, in addition to the above components include caffeine in an amount of 50 mg and propiphenazone (150 mg), and there is no diclofenac at all. Another difference between the Bol-Run and Bol-Run Premium tablets is the amount of paracetamol. If in the first preparation it contains 500 mg, then in the second - 250.
In addition to the active substances, all Bol-Run tablets contain a standard set of auxiliary components: starches, parabens, dyes and cellulose.
Pharmacy Holidays and Pill Storage
From pharmacies, the medicine is dispensed over-the-counter. However, it is recommended to take it strictly as prescribed by the doctor. Keep the tool “Bol-Run” (tablets) instructions advised away from heaters and direct sunlight. The maximum allowable temperature is 25 degrees. Duration of storage should not exceed the terms indicated on the package with medicines. After this period of time, the tablets are disposed of with household waste.
Pharmacokinetics and pharmacodynamics of the drug
The effect on the body of the drug "Bol-Run" application instructions connects with the properties of all its components. Paracetamol and diclofenac block the synthesis of prostaglandins, thereby reducing the severity of pain symptoms and inflammation in the focus of pain. The mechanism for eliminating pain by these components is based on their ability to reduce the sensitivity of nerve endings to various stimuli (including mechanical and physiological ones). Paracetamol also affects the structural substances of the hypothalamus, due to which it is able to regulate the processes of thermoregulation.
The drug "Bol-Run" (tablets) is absorbed in the digestive tract for a very short time. The relationship of diclofenac with serum proteins is more than 99%, paracetamol - at least 10%. The maximum concentration of the active substances of the drug in the synovial fluid and blood is reached 2-4 hours after administration.
Active substances and their metabolites have different periods and ways of excretion from the body. The half-life of diclofenac and its metabolites is about 1-3 hours. More than half of the total volume of this active substance is excreted through the urinary organs. The half-life of paracetamol and the resulting metabolites is a maximum of 3 hours. Excretion of compounds occurs mainly through the liver, and only 5% through the kidneys.
When the medicine "Bol-Run" is used
Consider a list of diseases and conditions in which the use of the drug "Bol-Run" is recommended. The instruction advises taking tablets in inflammatory joint diseases: rheumatism, osteoarthritis, gout, lumbago, rheumatoid and juvenile chronic arthritis, as well as with neuralgia and myalgia. In addition, the drug can be taken as an anesthetic for injuries (bruises, dislocations, fractures and burns).
In what other cases can I take Bol-Run tablets? The use of this drug is effective in almost any type of pain of small or medium intensity, including dysmenorrhea (primary). Also, the medicine helps to get rid of toothache, migraine and fever accompanying an inflammatory disease of an infectious origin.
Because of the components included in their composition, Bol-Run Premium tablets should be taken with a pronounced headache, pain in the muscles and joints of medium and strong intensity.
Dosage and administration
The instructions for taking the Bol-Run drug (tablets) are recommended by the patient based on the patient’s disease and age. In the classic version, the drug is taken 2-3 times a day, one tablet. The duration of treatment for pain is always determined by a specialist. For chronic pain that does not go away, it is recommended to take a maintenance dose of the medicine - 1 tablet every two days. According to the same scheme, the drug "Bol-Run Neo" is taken. Pills instruction advises drinking plenty of water (at least 0.5 cups).
Specialists draw the attention of patients to the fact that the maximum number of tablets taken per day should not exceed 4 pieces. In this case, the time interval between doses should be at least 4 hours.
Contraindications
The contraindications available for the Bol-Run preparation are mainly due to the negative effect of its components on the mucous membrane of the digestive system. So, tablets are not recommended for the treatment of pain for people with peptic ulcer of the stomach and duodenum. Particular care should be taken also for those who suffer from erosive diseases of the gastrointestinal tract.
In addition to the above contraindications to the use of the drug "Bol-Run" (tablets), the instruction mentions intolerance to some components of the drug. It is also not recommended to take it to people who at least once in their life have suffered an allergic reaction to aspirin and other non-steroidal anti-inflammatory drugs. Such a reaction may occur in the form of bronchospasm, acute form of rhinitis or urticaria.
Bol-Run Premium tablets are not recommended for patients who have a history of increased blood pressure or sleep disturbance (due to caffeine included in them). This medicine is strictly contraindicated for those who suffer from hypertension.
The use of Bol-Run tablets by pregnant and lactating mothers
Pregnancy and the period of breastfeeding according to the instructions for use of the drug are serious contraindications to the use of the drug "Bol-Run Premium", "Bol-Run Neo" and the usual "Bol-Run". The instruction advises to temporarily stop breastfeeding if it is necessary to conduct therapy with these drugs. Regarding the gestation period, experts agree that the risk of consequences from taking medication for the fetus should not exceed the possible benefit for the mother.
The use of the drug in childhood
The tablets with the analgesic and anti-inflammatory effect of "Bol-Run" are not recommended by specialists for the treatment of children under the age of 14 years. This instruction must be strictly observed. In this case, it is better to use other drugs with a similar mechanism of action as therapeutic agents.
Overdose: symptoms and treatment
If the recommended dosages and the regimen of taking the “Bol-Run” drug in the form of tablets are not observed, the patient may develop an overdose. The same can happen when treating pain with several drugs containing components such as paracetamol and diclofenac.
Symptomatically overdose can be expressed by bouts of severe headache, motor excitability, convulsions and dizziness. Also, the patient may be disturbed by nausea, vomiting, anorexia. The skin with an excess of paracetamol in the body becomes pale. Taking a significant amount of the Bol-Run preparation for several days can lead to liver cell necrosis. In addition, in isolated cases, an overdose provoked the development of renal failure.
Eliminating the effects of an overdose is a symptomatic treatment. Immediately after the appearance of characteristic symptoms, the patient is given gastric lavage (if the drug was taken once in a large amount) and activated charcoal or a solution of other sorbents is prescribed. In case of damage to the liver tissue, the introduction of methionine and acetylcysteine may be required. In addition, the doctor may decide to use SH-group donors.
Side effects
Both active components of the Bol-Run tablets can cause unwanted body reactions. That is why the list of side effects of the drug is so wide. All information about these phenomena is set forth in the table below.
Organs and systems | Frequency of occurrence | Symptoms of Adverse Reactions |
Gastrointestinal tract | Often or sometimes | Heartburn, nausea, gas, vomiting, belching |
Rarely | The development of erosion and ulcers in the stomach and intestines, pain in the epigastric region, intestinal perforation |
Skin integument | Often or sometimes | Itching, skin rashes |
Rarely | Urticaria (in the presence of an allergy to NSAIDs), photosensitivity |
Respiratory system | Rarely | Allergic bronchospasm |
Hematopoietic system | Often or sometimes | Anemia |
Rarely | Leukopenia, thrombocytopenia, agranulocytosis |
urinary system | Often or sometimes | Nephrotic Syndrome, Jade |
Rarely | Acute renal failure |
CNS | Often | Dizziness, irritability, fatigue, headache |
Rarely | Drowsiness, tinnitus, cramps, diplopia |
The cardiovascular system | Sometimes | High blood pressure, hypertensive crisis |
According to experts, side effects most often occur if the recommendations for dosing the drug are not followed. The depth of organ damage also depends on how accurately the instructions for the use of the drug were followed.
Drug interaction
Doctors prescribing Bol-Run tablets to their patients should consider a number of factors, including the ability of the drug to interact with other drugs. Very often, drug combinations are negative. If the recommendations set out in the instructions are not followed, an overdose may occur or the effect exerted by the drugs will be very weak.
What can the official instructions say about this? Bol-Run (Neo or Premium) should not be taken with other non-steroidal anti-inflammatory drugs. This can lead to overdose and other complications. The same applies to drugs from the group of anticoagulants. This combination very often leads to the appearance of side effects associated with the blood forming organs and the cardiovascular system.
Patients should pay particular attention to recommendations regarding the co-administration of Bol-Run tablets with alcohol and drugs belonging to the barbiturate group. Paracetamol, which is part of the drug, together with ethyl alcohol significantly enhances its negative effect on liver cells.
When prescribing this drug, it is necessary to inform the doctor of all medications taken over the past 2 weeks.
special instructions
Particular attention is required by patients who, at the time of administration of the Bol-Run medicine for oral administration, were diagnosed with impaired functioning of the kidneys and liver (including alcoholic origin), biliary tract, and cardiovascular diseases. If the drug is prescribed according to unconditional indications, monitoring of the condition of the kidneys, liver and cardiac activity is necessary throughout the entire duration of therapy.
Due to the fact that dizziness and drowsiness are mentioned among the undesirable reactions of the body to taking this medicine, it is not recommended to perform work at height, drive vehicles and operate complex mechanisms during treatment with Bol-Run tablets.
Reviews about the tablets "Bol-Run"
What do consumers and healthcare providers say about Bol-Run? Reviews about this medicine can be found often. Almost all of them are positive. Consumers speak of tablets as very effective. According to them, the pain after taking the medicine decreased within 30-50 minutes, and within the next 2 hours it completely disappeared.
The fact that the drug has side effects that impede its further intake, there are practically no reviews. There is also little information about an overdose. According to experts, this is because most patients tend to trust doctors regarding their recommendations.