Cream "Devirs" - a drug for external application, which has a pronounced antiviral effect.
The drug is widely used for herpetic diseases of the skin surface and mucous membrane. The medication helps to effectively cope with herpes zoster.
Structure
Cream "Devirs" is produced in the form of a homogeneous cream milk shade for external use. The active substance of the drug is ribavirin, the concentration of which is 7.5 grams.
In addition, the drug has the following additional components:
- macrogol-6 alcohol ether;
- 25 cetostearyl;
- glyceryl monostearate;
- cetostearyl alcohol;
- paraffin;
- methyl parahydroxybenzoate;
- water.
Cream "Devirs" is dispensed from pharmacies in aluminum tubes, the capacity of which is five, fifteen and thirty grams.
Pharmacological actions
The active substance belongs to potent inhibitors of inosine, as well as RNA polymerase and mRNA guanylyltransferase of the viral parts. Inhibition of the activity of the latter helps to deplete the reserve of guanosine triphosphate inside the cell, and also leads to the cessation of the production of viral ribonucleic acid and polypeptides.
In addition, ribavirin can cause the development of fatal mutations, as well as a decrease in the pathogenicity of the infectious agent. The medicine reduces the rate of reproduction of new viruses, which inhibits the spread of pathogens in properly functioning cells.
Excessive sensitivity to the active component is observed in DNA viruses:
- Herpes simplex (a viral disease with a characteristic rash of grouped vesicles on the skin and mucous membranes).
- Cytomegalovirus (belongs to the family of herpes viruses and causes cytomegaly during the development of the disease).
- Adenovirus (acute viral infectious process, accompanied by damage to the respiratory tract, eyes, lymphoid tissue, digestive tract).
- Herpes Zoster (a disease that causes great trouble to the patient and is accompanied by itching and pain).
And also hypersensitivity was noted in RNA viruses:
- Paramyxoviruses.
- Rhinoviruses.
- Influenza A and B.
- Bunyaviruses.
- Oncogenic RNA viruses.
Cream "Devirs": indications
According to the instructions for use, it is known that the drug is widely used as monotherapy, as well as in combination with other drugs. The drug is prescribed in the following situations:
- Herpes zoster (a disease of viral nature, which is characterized by unilateral painful rashes on the skin and a general deterioration of the body).
- Violation of the skin and mucous membranes of the Herpes simplex virus of the first and second type.
How to apply the drug?
Medication "Devirs" must treat the damaged areas of the skin and mucous membrane that have been previously processed and dried. The drug is distributed in a thin layer, gently rubbing the medication, up to five times a day until the signs of herpes infection are eliminated.
According to the instructions for use with Devirs, it is known that if there is no improvement after eight days, then you need to abandon the use of the medication in the future, then consult a doctor.
To increase the effectiveness of treatment and reduce the duration of therapy, it is necessary to apply the cream when the first symptoms of herpes occur: redness and itching. If the drug is prescribed in conjunction with other ribavirin medicines, it is necessary to reduce the frequency of use of the local drug.
What negative reactions does the medicine cause?
According to the instructions for use with Devirs, it is known that the drug is generally well tolerated by patients, but sometimes certain adverse reactions may occur:
- Urticaria (an allergic or toxic disease, manifested in the form of pinpoint red spots - the main symptom of urticaria is unpleasant itching).
- Exanthema (an acute infectious disease of young children caused by the herpes virus of the 6th and 7th type, proceeding with a temperature reaction and skin rashes).
- Rashes.
- Alopecia (pathological partial or complete loss of hair on the head, face, or other parts of the body that occurs as a result of damage to the hair follicles).
- Violation of the production of thyroid-stimulating hormone of the endocrine gland.
- The manifestation of symptoms of autoimmune pathological processes (a group of diseases with various clinical manifestations, but with a similar mechanism of action, in which the human immune system begins to perceive its own cells and tissues as foreign and attack them).
What other negative effects can the drug provoke? A medicine can cause the following conditions and diseases:
- Hyperemia (a condition caused by excessive filling of capillaries with blood, which as a result causes the development of redness in a certain area).
- Photosensitivity (the phenomenon of increasing the body's sensitivity to ultraviolet or visible radiation).
- Hyperthermia (a protective and adaptive reaction of the human body, which manifests itself in response to the negative effects of various irritants).
- Nausea.
- Vomiting.
- Hyperhidrosis (a pathological condition accompanied by increased sweating throughout the body).
All of the above signs do not affect the effectiveness of treatment. These negative phenomena are considered reversible, therefore, pass immediately after stopping the use of the medication.
Overdose
According to the instructions for use with the Devirs cream, it is known that an excess of the pharmacological dosage of the drug is possible only if the cream is accidentally inside. In such situations, an increase in dose-dependent adverse reactions is noted.
If signs of poisoning appear, it is necessary to stop using the drug, as well as carry out complex treatment.
Limitations
Contraindications to the cream "Devirs" are the following conditions:
- Period of pregnancy.
- Intolerance to any ingredients of the drug.
- Lactation.
- Age under eighteen.
- Increased sensitivity to drug substances.
- Kidney and liver disease.
With special care, it is necessary to take men and women of reproductive age.
Features
According to the instructions for use, it is known that the cream "Devirs" is not intended for the treatment of ophthalmic herpes, therefore it is contraindicated to use the medication in the field of the visual organ.
With extreme caution, it is necessary to apply an antiviral drug to people with kidney disease. Reliable contraceptive methods should be used for patients of reproductive age, regardless of gender, during the course of treatment and seven months after therapy.
The cream should be kept in a dark and inaccessible place for children, the temperature regime of storage should not exceed twenty-five degrees. Duration of storage is twenty-four months. After this period, the drug must be disposed of.
Substitutes
The following drugs have a similar effect:
- Arviron.
- "Virazole".
- Ribapeg.
- "Vero-ribavirin."
- Rebetol.
- Ribavin.
- "Trivorin."
Such drugs have a pronounced antiviral effect. But medical experts recommend abandoning an independent change of the drug. The cost of the drug "Devirs" varies from 500 to 1200 rubles.
Customer reviews
Reviews about the cream "Devirs" are mostly approving, characterize his patients as an excellent medicine for eliminating the external manifestations of herpes on the lips and other parts of the body.
Naturally, it is practically impossible to completely eliminate the herpes virus, which in a mild form exists in the body of absolutely every person.