"Sedalgin": instructions for use, reviews, analogues

In the article, we consider the instructions for use, price and analogues for the Sedalgin preparation.

A pharmacological agent is a combined medication that has anti-inflammatory and analgesic effects. Among its main analogues, Sedalgin Plus and Sedalgin Neo can be noted , however, it should be noted that the indications for the use of these drugs are slightly different. According to the instructions, "Sedalgin Plus" is prescribed, as a rule, with an increase in temperature and the presence of an inflammatory process, while the effect of "Sedalgin Neo" is aimed at reducing the intensity of the pain syndrome and providing a sedative effect. The drugs included in the pharmacological group "Sedalgin" are combined medicines that have antipyretic, analgesic and anti-inflammatory effects.

Release form

As indicated by the instructions for use, "Sedalgin" is available in the form of tablets for oral use (inside). They have a smooth flat surface, round shape and white color.

Structure

The composition of the drug includes several main active ingredients, the content of which in the tablet is:

• sodium metamizole - 500 mg;
• caffeine - 50 mg;
• thiamine hydrochloride - 38.75 mg.

Also, in accordance with the instructions for use, Sedalgin contains some additional substances, which include magnesium stearate, wheat starch, colloidal silicon dioxide, microcrystalline cellulose, gelatin and talc.

Tablets are packed in a blister of 10 pieces, which are in cardboard packs of one or two blisters, along with instructions for use of this medication.

Pharmacokinetics and pharmacodynamics

As the instructions for use for Sedalgin informs us, the antipyretic and analgesic therapeutic effect of the drug is realized due to the action of the main active ingredients:

1. Metamizole, which represents the category of anti-inflammatory non-steroidal drugs. It is able to suppress the activity of COX (cyclooxygenase) enzymes responsible for the conversion of arachidonic acid to prostaglandins, which are the main mediators of the inflammatory process in its focus. By reducing the concentration of prostaglandins, the severity of the inflammatory reaction that they provoke, namely the pain syndrome (prostaglandins irritate nerve endings), significantly reduces tissue swelling. When metamizole acts on the center of thermoregulation in the medulla oblongata, body temperature begins to decrease, which accompanies the development of fever caused by intoxication of various etiologies.
2. Caffeine, which is one of the stimulants of brain activity, reduces the severity of feelings of fatigue and weakness against the background of inflammation in the body. In addition, caffeine has the ability to reduce the intensity of spasms of the arteries of the brain, thereby reducing the severity of cephalgia.
3. Thiamine, which is vitamin B1, is part of a wide variety of enzymatic cell systems in the body that are responsible for energy production and glucose utilization. Its intake provokes an increase in energy reserves in cells, as well as an improvement in the functional activity of all systems and organs.

All the active components of the drug "Sedalgin" are almost completely absorbed into the blood from the intestines, after which they are evenly distributed in the tissue cells, penetrating the placental and blood-brain barriers. Metabolism occurs mainly in the liver with the formation of inactive decay elements, which are excreted, as a rule, through urine.

What else can you learn from the instructions for use for "Sedalgin"?

Indications for appointment

The drug is indicated as a means of symptomatic therapy to combat moderate pain syndrome. Thus, the list of indications for its use includes:

• headache of various etiologies, including migraines;

• algodismenorea (menstrual pain) in women;
• arthralgia (joint pain) caused by a variety of degenerative-dystrophic or inflammatory processes in the joint tissue;

• myalgia, which is muscle pain of various etiologies;
• neuralgia - pain in the projection of the peripheral nerves affected by the inflammatory process;
• radicular syndrome, which causes the onset of pain in those areas of the body that are innervated by nerve fibers of a nerve root impaired during pathologies of the spine;
• moderate pain toothache.

In addition, this drug is used to eliminate the manifestations of fever in bacterial and viral infections, but only after a diagnosis has been established and the reasons for the increase in body temperature have been determined.

Contraindications

Instructions for use for "Sedalgin" indicates that a number of physiological pathological conditions and conditions in which the use of the drug is impossible are distinguished. These include:

• intolerance to any of the medical elements of the drug, as well as high sensitivity to pyrazolidone and its derivatives (this compound is considered the precursor of metamizole, which is one of the main components of this drug);
• severe renal or hepatic functional impairment;
• glaucoma (increased intraocular pressure).
• arteriosclerosis of arterial vessels, which is accompanied by the deposition of cholesterol in their walls;
• arterial hypertension (increased blood pressure), which is difficult to control;
• pregnancy and lactation;
• children under 12 years old.

This medication should be used with caution in cases of moderate activity of kidney or liver failure.

Dosage and administration

According to the instructions for use, tablets "Sedalgin" should be taken orally after a meal. The tablets are not crushed and washed down with a large volume of water. The average dosage can be 3 tablets per day, which are taken at regular intervals. The maximum single dose for children over 16 years of age and adults is two tablets. A day is allowed to take no more than six tablets of Sedalgin. The instructions for use confirm this.

Acceptance of the maximum dosage is allowed for two days. At the age of 12 to 16 years, the recommended therapeutic dose is from ½ to 1 tablet 2 times a day, the maximum allowable dosage per day should not exceed four tablets. The course of therapy with this medication with the goal of anesthesia should not last more than five days, while fighting fever - no more than three days.

In cases where the symptoms after the course of therapy with Sedalgin tablets persist or its intensity increases, it is recommended to consult a doctor.

Adverse reactions

In accordance with the instructions and reviews about "Sedalgin", against the background of treatment with this pharmacological agent, undesirable pathological phenomena may occur, which include:

1. In the digestive system - a decrease or lack of appetite, periodic nausea and vomiting, impaired excretion of bile in the structures of the hepatobiliary system accompanied by jaundice.
2. Heart and blood vessels - a violation of heart contractions (arrhythmia), the occurrence of sensations of a heartbeat.
3. Red bone marrow and blood - a decrease in the number of platelets (thrombocytopenia), white blood cells (leukopenia), granulocytes (agranulocytosis), excessive destruction of red blood cells (anemia).
4. Nervous system - increased nervous excitability, sleep disturbance, dizziness.
5. Allergic manifestations - skin rash and itching, urticaria, swelling of soft tissues with localization in most cases in the face and genitals (Quincke's edema), narrowing of the bronchi with impaired respiratory function (bronchospasm), systemic reactions with multiple organ failure and a marked decrease in pressure.

The occurrence of the above signs of pathological reactions is considered the basis for the fact that taking Sedalgin tablets should be stopped and consult a doctor.

special instructions

Also, the instructions for tablets "Sedalgin" tells us that there are several recommendations for the use of this medication, which you need to pay attention to:

1. Taking drinks containing caffeine during treatment with the drug can lead to symptoms of an overdose and pathological reactions from the central nervous system and heart.
2. The presence of hay fever or bronchial asthma while taking this medication can provoke the development of other allergic reactions.
3. Against the background of the use of a medical product, the intake of alcoholic beverages is not recommended.
4. The increase in therapeutic dosages and the duration of the treatment course is determined only by the doctor.
5. The main components of the medication can interact with other medicines (barbiturates, tricyclic antidepressants, other anti-inflammatory, non-steroidal medicines, cyclosporine), therefore, when using them, you should warn the doctor.
6. Care must be taken when performing work involving the need for increased concentration of attention and speed of mental reactions.

This is stated in the instructions for use. Reviews about "Sedalgin" consider below.

Overdose

A significant excess of the recommended therapeutic dosages of the drug may be accompanied by symptoms of an overdose. They are usually manifested by nausea, vomiting, cardiac arrhythmias, increased nervous agitation, convulsions up to epileptic seizures, impaired consciousness, marked increase in temperature, headache, increased skin sensitivity, ringing in the ears.

When signs of an overdose appear, the patient is washed in the stomach, enterosorbents are taken, and symptomatic therapy is prescribed in the hospital.

Such information is contained in the instructions.

Analogs of "Sedalgin"

This medication has a huge list of analogues. These include:

• "Analgin";
• Spazgan
• Pentalgin;
• Andipal;
• Tempalgin;
• "Sedal - M";
• "Baralgin";
• "Revalgin";
• "Baralgeta";
• Spazmil-M;
• "Cofalgin";
• "Realgin";
• "Spazmadol" and others.

Drug price

The approximate cost of packaging with Sedalgin medicine in the pharmacy chain varies from 136-152 rubles. It depends on the region.

Reviews

The drug "Sedalgin" has existed for a long time on the domestic pharmacological market, in connection with which a large number of reviews were left about this drug. They are both positive and negative.

Some patients are very pleased with this medication, because, in their opinion, it is one of the most powerful painkillers that can be used when a variety of pain occurs. They note that the drug acts very quickly, relieves pain, reduces temperature, reduces the intensity of the inflammatory process. This category of people did not notice the appearance of negative reactions during therapy with this drug or very minor pathological conditions were observed.

Another group of patients who left negative reviews about this drug, believes that this medication is very toxic, changes the level of blood pressure, which excludes the possibility of its use in some patients. In addition, many observed pronounced side effects in the form of pulsation in the temples, cardiac arrhythmias, dyspeptic disorders, etc. In such cases, they had to interrupt therapy with this drug and consult a specialist for treatment adjustment.

Doctors reviews

Reviews of experts contain information that this drug is very effective, but very toxic, often causes adverse reactions and impaired functioning of the kidneys, as well as the liver and biliary tract. Therefore, according to doctors, the medication should be used only in emergency cases.

We examined the drug "Sedalgin" instructions for use, reviews and analogues.