All people know what pain is and how much it affects the quality of life. Modern pharmacology offers a large number of medicines that will help to cope with this problem.
One of the most effective drugs in this area is Naysulide powder. What helps the drug? The answer will be given in this article.
But it is not recommended to forget that it is impossible to use the medicine without the appointment of a medical specialist.
What is part of the medicine
According to the instructions, the composition of the powder "Naysulide" includes one active substance - nimesulide. Additional components are:
- xanthan;
- silica;
- lemon oil;
- a salt of calcium and stearic acid;
- citric acid;
- food supplement E951;
- granulated sugar.
According to the instructions for use with Naysulide powder, Belarus is a country of manufacture.
Characteristic
The powder has a white or yellowish tint with a specific aroma. Naysulide is a non-steroidal anti-inflammatory drug that has analgesic and antipyretic properties.
After oral administration, nimesulide is well absorbed from the stomach and intestines. The maximum content in the blood is reached after two to three hours after application.
Indications for the powder "Naysulid"
According to the instructions, it is known that the medication is prescribed in the presence of the following diseases and conditions:
- Pain syndrome in gynecological diseases.
- Injuries.
- Osteoarthritis (a disease of the musculoskeletal system that affects large and small joints of the arms and legs).
- Rheumatoid arthritis (a systemic disease of the connective tissue with a primary lesion of small joints as an erosive-destructive polyarthritis of unknown etiology with complex autoimmune pathogenesis).
- Bursitis (inflammation of the mucous bags primarily in the joints).
- Tendonitis (inflammation and dystrophy of tendon tissue, similar in symptoms to tendinosis).
- Dysmenorrhea (a pathology in which during menstruation there are pronounced pain in the lower abdomen).
Limitations
According to the instructions for Naysulide powder, contraindications for use are:
- Hypersensitivity.
- Bronchospasm (narrowing of the bronchi).
- Rhinitis (inflammation syndrome of the nasal mucosa).
- Alcoholism.
- Nettle rash.
- Severe impaired liver function.
- Renal failure.
- Severe kidney disease.
- Ulcerative lesions.
- Phenylketonuria (a hereditary disease of the enzyme group, associated with a violation of the metabolism of amino acids, mainly phenylalanine).
- Pregnancy.
- Breast-feeding.
- Age to twelve years.
- Fever.
How to take Nysulide powder during pregnancy?
Is the medication prescribed for an "interesting situation"
Like other non-steroidal anti-inflammatory drugs, Naysulide can not be used by women who are planning a pregnancy.
According to the instructions for Naysulide powder, the active substance can cause premature closure of the botallic duct, as well as a number of other problems:
- Pulmonary hypertension (a group of diseases characterized by a progressive increase in pulmonary vascular resistance, which leads to right ventricular failure and premature death).
- The likelihood of bleeding and peripheral edema increases.
In addition, there are reports of the birth of children with kidney diseases in women who took Nysulid in the last trimester of an "interesting situation."
Nysulide powder: method of application
Before taking, you need to prepare a solution. To do this, the contents of the sachet must be diluted in 100 milliliters of water and mix well. After that, the finished mixture is immediately consumed. The suspension must be taken after a meal.
For adult patients, the medicine is prescribed in a single concentration of 100 milligrams. Adolescents between the ages of twelve and eighteen years of age and elderly patients do not need dose adjustment. The drug is forbidden to give to children under 12 years of age.
In renal failure, dosage adjustment is not required. In severe renal failure, the drug is prohibited to use.
Method of application: Naysulide powder is used for a short period to minimize the likelihood of side effects. The maximum duration of therapy should not exceed fifteen days.
Adverse reactions
Like any other medicine, Nysulide provokes the appearance of undesirable effects:
- Hypertension (a pathological process, which consists in a significant increase in blood pressure, which requires systematic therapy).
- Tachycardia (increased heart rate).
- Change in blood pressure.
- Hyperkalemia (an ailment characterized by an increase in the concentration of potassium in the bloodstream).
- Anemia (a disease characterized by a decrease in hemoglobin in the blood).
- Eosinophilia (a condition in which there is an absolute or relative increase in the number of eosinophils).
- Bleeding.
- Thrombocytopenia (a pathological condition characterized by a decrease in the number of platelets circulating in the peripheral blood).
- Pancytopenia (a hematological concept denoting a decrease in the level of all types of peripheral blood cells).
- Purple (a disease characterized by small spotted capillary hemorrhages under the skin, in the epidermis or mucous membranes).
- Diarrhea (a pathological condition in which the patient has frequent bowel movements, while the stool becomes watery).
- Nausea.
- Vomiting.
- Constipation.
- Bloating.
- Gastritis (inflammatory or inflammatory-dystrophic changes in the gastric mucosa; a long-lasting disease characterized by dystrophic-inflammatory changes, proceeds with a violation of regeneration, as well as with atrophy of epithelial cells and the replacement of normal glands with fibrous tissue).
- Abdominal pain (pain discomfort of the abdominal cavity, characterized by localization, the nature of the occurrence, indicating a violation of the functions of the internal systems of the body).
- Dyspepsia (a violation of the normal activity of the stomach, difficult and painful digestion).
- Stomatitis (damage to the mucous membrane in the oral cavity, which is inflammatory in nature).
- Gastrointestinal bleeding (outflow of blood from blood vessels eroded or damaged by the pathological process into the lumen of the digestive organs).
- An ulcer of the stomach and duodenum (chronic polyetiological pathology that occurs with the formation of ulcerative lesions in the stomach, a tendency to progression and the formation of complications).
- Hepatitis (diffuse inflammation of the liver tissue due to a toxic, infectious or autoimmune process).
- Jaundice (icteric staining of the skin and visible mucous membranes, which is due to the high concentration of bilirubin in the blood and tissues).
- Cholestasis (a disease manifested in the form of stagnation in the liver tissue of bile components with a concomitant decrease in its entry into the duodenum).
- Itching
- Rashes.
- Hyperhidrosis (sweating problems, which are characterized by increased production of sweat, as a result of impaired functioning of the autonomic nervous system).
- Increased Sensitivity.
- Exanthema (dermatological rashes in the form of papules, vesicles, spots of various sizes).
What other undesirable reactions does the medication provoke? According to the instructions, Nisulide powder causes the following side effects:
- Erythema (limited intense redness of the skin due to vasodilation of the dermis).
- Anaphylactic shock (an allergic reaction of an immediate type, a state of sharply increased sensitivity of the body).
- Urticaria (a disease of an allergic or toxic nature, manifested in the form of pinpoint red spots).
- Quincke's edema (a reaction to the effects of various biological and chemical factors, often of an allergic nature).
- Steven-Jones syndrome (acute toxic-allergic disease, the main characteristic of which are rashes on the skin and mucous membranes).
- Epidermal necrolysis (a serious illness accompanied by rejection of the surface layer of the skin and impaired functioning of the internal organs).
- Dizziness.
- Anxiety.
- Irritability.
- Loss of sleep.
- Migraine (the primary form of headache, the symptoms of which are periodic bouts of headache of medium and high intensity).
- Encephalopathy (a generic name for pathological processes of various genesis, the basis of which is the degeneration of brain neurons due to metabolic disorders).
- Reye's syndrome (a dangerous disease, which is characterized, as a rule, by damage to the brain and the accumulation of fat in the liver).
- Drowsiness.
- Dysuria (violation of the activity of the organs of the excretory system, which is characterized by problems with urination).
- Hematuria (the presence of blood in the urine).
- Urine delay.
- Renal failure.
- Oliguria (a significant decrease in daily urine output).
- Interstitial nephritis (a pathological process characterized by an acute or chronic inflammatory process in the interstitial tissue and tubules of the kidneys).
- Difficulty breathing.
- Asthma (a chronic disease characterized by short-term attacks of suffocation due to spasms in the bronchi and swelling of the mucous membrane).
- Bronchospasm (a pathological condition that occurs when the smooth muscles of the bronchi are contracted and their lumen is reduced).
- Edema.
- Visual impairment.
- Vertigo (a symptom known as dizziness, it is characteristic of ear pathology or brain damage).
- Malaise.
- Asthenia (impotence, painful condition or chronic fatigue, manifested in the exhaustion of the body with increased fatigue and with an extreme degree of mood instability, impatience, sleep disturbance, restlessness).
- Hypothermia (a condition of the body in which the body temperature drops lower than is required to maintain normal metabolism and functioning).
Analogs
According to reviews, Nisulide powder has certain substitutes:
- Nimesulide.
- Novolid.
- Mesulide.
- "Nimesil."
- Nimulide.
- "Nimica."
- Nemulex.
- Nise.
- "Prolide."
- Aponil.
- "Ameolin."
- "Actasulide."
Before replacing the original medicine with a generic, you should consult a doctor.
Interaction
According to the instructions for use with Naysulide powder, its simultaneous use with Warfarin or other anticoagulants, as well as Aspirin, causes the occurrence of bleeding. Therefore, this combination is not recommended and prohibited for patients with various disorders of blood coagulation.
The combination of taking Naysulide with diuretic drugs may negatively affect renal hemodynamics. With the simultaneous use of the drug and Furosemide, the excretion of sodium and potassium decreases briefly, and as a result, the action of diuretics worsens.
This combination requires increased attention in people with impaired heart or kidney function. The simultaneous use of Naysulide with diuretic drugs can adversely affect renal hemodynamics.
Reception of nimesulide less than one day before or after methotrexate therapy leads to an increase in the content of the latter in the blood, which increases its toxicity.
The effect of Nisulide on prostaglandinsynthetase and renal prostaglandins can lead to increased cyclosporin nephrotoxicity.
With alcohol
During the treatment of various diseases with the use of Naysulida, it is not recommended to take any strong drinks. This combination can cause an increase in negative side effects and lead to severe deterioration in health.
Recommendations
The likelihood of adverse reactions can be reduced by using Naysulide powder for a short time. In the absence of a therapeutic effect, it is necessary to stop taking the medicine.
Hepatotoxic effects, which include fatal situations, can rarely occur. If anorexia, nausea, vomiting, abdominal pain, fatigue and dark urine appear, treatment should be discontinued. Most cases of liver damage can be eliminated by using Naysulide for a short time.
The combination of nimesulide with other hepatotoxic drugs and alcohol should be avoided due to the increased risk of hepatotoxic effects. Naysulide is used with extreme caution with other painkillers. Combining the drug with other non-steroidal anti-inflammatory drugs is not recommended.
Gastric and intestinal bleeding can occur throughout the entire period of therapy without symptoms or with pronounced signs even in the absence of gastric and intestinal diseases. With the development of adverse reactions, treatment with Naysulide should be discontinued. The drug is used with extreme caution in case of damage to the gastrointestinal tract, including peptic ulcers, ulcerative colitis or Crohn's disease.
Retired patients are especially sensitive to non-steroidal anti-inflammatory drugs. When using Naysulide, they may develop gastrointestinal hemorrhages and perforations, as well as diseases of the kidneys, heart and liver, therefore, it is necessary to constantly be monitored by a medical specialist.
Since the medication can suppress platelet activity, it should be used with caution in people with problems with blood coagulation. But Naysulide is not considered a substitute for Aspirin for the prevention of cardiovascular diseases.
Since the drug has an antipyretic effect, when it is used for infectious pathologies, there is no increase in temperature, which can complicate the diagnosis of the disease.
There is no information on the effect of Nysulide on concentration. But patients with side effects from the central nervous system and vestibular apparatus need to refrain from driving a car and work that requires an increased concentration of attention. The structure of the drug includes sugar, which is important to consider when treating patients with diabetes.
How to store the medicine
Keep the medicine away from light and at a temperature of no more than twenty-five degrees of heat. Keep Nysulide away from children.
Shelf life is 2 years. The cost of the drug varies from 180 to 200 rubles. They release the medicine according to the doctor’s prescription.
Opinions
A large number of reviews of Nysulide are positive. The drug is quite effective in the elimination of pain, temperature, various kinds of inflammatory processes. Nysulid helps instantly and its impact is lasting.
It is rare to find negative feedback regarding the side effects of a medicine. If the dosage is exceeded, a person may develop nausea, vomiting, palpitations, which pass immediately after discontinuation of the drug.