To improve heart function and overall well-being, the drug “Concor” (tablets) is prescribed. What exactly is it used for and how to use the medicine correctly? Let's talk about this in an article.
Indications for use
High blood pressure, chronic heart failure, angina pectoris are far from rare occurrences. Moreover, in recent years there has been a tendency to "rejuvenate" such pathologies. It is hard to say what this is connected with. Typically, such complications are preceded by various heart diseases (endocarditis, myocarditis, pericarditis), some autoimmune ailments (rheumatic fever, psoriatic and rheumatoid arthritis and others), damage to systems and organs (liver, lungs, spleen). In order to prevent the development of severe complications of these ailments, it is necessary to treat them timely and adequately. For this purpose, the medicine “Concor” (tablets) is used. What is this drug used for, we found out, now we will discuss the mechanism of action of the drug.
How does the medicine “Concor” work?
The drug is a highly effective selective beta-1-blocker of long action. The active substance of the drug is bisoprolol hemifumarate (one tablet may contain 5 or 10 mg). The medicine also contains excipients: colloidal silicon dioxide, corn starch, microcrystalline cellulose, magnesium stearate, calcium hydrogen phosphate, crospovidone. Under the influence of the “Concor” medication, adrenaline and norepinephrine do not get on beta-1-adrenergic receptors, due to which myocardial excitability and conductivity are suppressed, blood pressure decreases (most often used from “Concor” pressure), the heart rate normalizes, the coronary vessels expand. If you take the drug at the doses recommended by your doctor, it does not affect the organs that contain beta-2-adrenergic receptors (for example, in the bronchi). High doses act on these receptors and this is manifested primarily by bronchospasm.
Pharmacokinetics
The medicine is quickly absorbed from the digestive tract. Bisoprolol is distributed quite widely, the binding of blood plasma proteins with this substance reaches about 30%. Part of the drug (up to 50%) is excreted unchanged by the kidneys, the rest - after decomposition in the liver to metabolites, is also excreted by the kidneys.
Instructions for use of the drug "Concor" (tablets)
From whatever the medication is prescribed, take it in the morning once a day, regardless of food intake. Grinding or chewing tablets is not recommended.
- Angina pectoris and arterial hypertension. The dose of “Concor” is selected individually from high blood pressure individually and depends on the heart rate and the patient’s well-being. Usually prescribed no more than 5 mg of the drug. According to the doctor’s recommendation, the daily dose of the drug can be increased to 10 mg, up to a maximum of 20 mg.
- Chronic heart failure. In this condition, the initial dose of the drug is 1.25 mg. Gradually increase the dose to 2.5; 3.75; 5; 7.5 and 10 mg. The minimum break between dosage increases should be 2 weeks.
Contraindications to the use of the medication "Concor" (tablets)
From what and how to take the medicine correctly, it was described above, but you should also know that the drug can not be used with:
- individual intolerance to the main and or auxiliary components, as well as other beta-blockers;
- acute heart failure ;
- decompensated heart failure;
- shock conditions caused by cardiac abnormalities;
- sinoatrial blockade;
- severe bradycardia;
- marked decrease in blood pressure;
- bronchial asthma (in severe form);
- severe violations of arterial peripheral circulation;
- chronic obstructive pulmonary diseases;
- metabolic acidosis;
- Raynaud's disease.
Use the medication with caution in conditions such as:
- Prinzmetal angina pectoris ;
- diabetes mellitus, which is characterized by significant fluctuations in the amount of glucose in the blood;
- diabetes mellitus (type 1);
- restrictive cardiomyopathy;
- severe liver failure;
- psoriasis;
- congenital heart defects;
- hyperthyroidism;
- desensitizing treatment in patients who adhere to a strict diet.
Finally
Those patients who took pills for pressure "Concor", reviews are mostly positive, they indicate the high effectiveness of the medication. However, this is only subject to all doctor's recommendations. In any case, only a specialist should prescribe this medicine, which will take into account the characteristics of the body and the severity of the disease. Self-medication is unacceptable!