Damage to the spine, acute pain in the joints and a change in the functions of the connective tissue due to inflammation - unfortunately, such diseases have become the most common in our time. This state of affairs is affected by lifestyle, lack of normal physical activity, hereditary factors. In addition to the severe pains that people suffer in this state, the ailment can destroy the whole body, changing the chemistry of the blood and affecting the normal functioning of the internal organs.
Therefore, it is so important to monitor your health and treat diseases on time. One of the effective drugs, which belongs to the group of non-steroidal drugs, is called the Celebrex medication. Doctors' reviews confirm its effectiveness in comparison with a similar line of anti-inflammatory drugs.
The main effect of the drug
The advantage of the drug can be called its ability to suppress the activity of the inflammatory process at different stages of the disease. Once in the blood, the drug is able to inhibit COX2, which leads to the process of stopping inflammation. The medicine "Celebrex" has a pronounced analgesic property, antipyretic activity. Therefore, it not only eliminates the foci of inflammation, but also perfectly relieves even acute pain, reduces fever.
The advantages of this drug include its minimal effect on platelets, that is, the medicine does not cause problems with blood coagulation. When taking this non-steroidal drug, there is no irritation of the mucous membrane of the stomach and intestines, the risk of ulcers and gastritis in patients is reduced.
Therefore, Celebrex tablets are used much more widely than other NSAIDs: Naproxen, Acetylsalicylic acid, Ibuprofen.
Directional action
Capsules "Celebrex" have the ability to reduce severe pain in the joints, eliminate their stiffness, cope with excessive swelling. Such an effect made it possible to treat patients with a diagnosis of rheumatoid arthritis, osteoarthritis. The effect of the drug reaches its maximum effect after 24-48 hours after the first dose. With dysmenorrhea, the drug effectively eliminates pain, even the most acute. It is also effectively used to relieve pain after surgical interventions (maxillofacial and orthopedic surgery).
For patients with ankylosing spondylitis, Celebrex helps to avoid pathological processes and improves the functional ability of the body. When observing the dynamics of familial adenomatous polyposis, the use of the drug led to a significant decrease in the growth of polyps in the colon and duodenum: their number and size were reduced. Doctors say that adequate doses of the medication and adherence to the treatment regimen can achieve excellent results when using the drug Celebrex. Patient reviews indicate minimal side effects when taking this medication.
Form and composition of the drug
A highly selective inhibitor is gelatin capsules of almost white or white color, they are not transparent and are marked in the form of blue stripes with the inscription: “7767” on one side and “100” or “200” on the opposite. The contents of the capsule: granulate white color.
The composition of the drug includes: celecoxib (the main active ingredient), lactose, povidone K30, sodium lauryl sulfate, magnesium stearate, croscarmellose sodium. The shell is made of titanium dioxide and edible gelatin. If it is advisable to administer the drug intramuscularly, Celebrex injections are prescribed. This type of medicine is available in the form of an injection solution of 2.2 ml in ampoules - the main substance of celecoxib.
Pharmacokinetics
The drug is well absorbed into the blood when taken on an empty stomach and reaches its maximum levels after about 2-3 hours. However, the use of the drug along with fatty foods can delay its accumulation by 1-2 hours. Therefore, it is worth consulting with the doctor about the time of taking the medicine.
Once in the bloodstream, active substances do not bind to red blood cells, however, this mechanism does not affect the achievement of the desired concentration of the drug in the body. The drug is metabolized in the liver by oxidation and glucuronidation with the participation of the enzyme CYP2C9. The drug is excreted with urine and feces in the form of simple metabolites and only 3% of the active substance remains unchanged.
The drug “Celebrex”, the analogues of which are similar in composition, is recognized as a means that causes minimal harm to health, due to the ability to be absorbed as much as possible and almost completely eliminated from the body. With low body weight, a higher concentration of the drug in the blood is observed, and this phenomenon is observed more in women. It is not known why, but people of the Negroid race have the same dynamics. Therefore, these groups of patients are prescribed lower doses of the drug at the beginning of therapy.
Indications for use
As a non-steroidal anti-inflammatory drug for symptomatic treatment, Celebrex is prescribed. Indications for use:
- rheumatoid arthritis;
- osteoarthritis;
- spondylitis;
- algodismenorea;
- acute pain (postoperative period, back pain, musculoskeletal diseases);
- used in the complex treatment of adenamotous polyposis.
It is worth noting that only the attending physician can prescribe adequate treatment on the basis of studies.
Methods of taking the drug
It is necessary to take the drug inside, regardless of the meal. Chew tablets should not be washed down with plain water. It is worth noting that with prolonged use of the drug, cardiovascular complications may occur. Therefore, doctors prescribe a short course of treatment with Celebrex. Reviews of experts confirm that the maximum dose with prolonged treatment should not exceed 400 mg per day!
- Treatment of osteoarthritis - an adequate dose is 200 mg per day. A one-time reception or divided into two (at equal intervals) is possible.
- Rheumatoid arthritis - a dose of 100 or 200 mg is suggested up to 2 times a day. With especially severe manifestations - up to 400 mg, twice a day.
- Ankylosing spondylitis - 200 mg per day, for 1 or 2 doses. At the discretion of the doctor, the dose may be increased to an adequately safe
- Dysmenorrhea and severe pain syndrome - therapy begins with 400 mg per day and 200 mg is added if necessary on the first day of therapy. In the following days, 200 mg should be taken twice a day.
The duration of treatment is determined by the attending physician.
Contraindications to the use of the drug
In addition to possible allergic reactions to the components of the drug, there are restrictions under which it is forbidden to use the drug "Celebrex":
- Asthma is bronchial, urticaria, allergy to other NSAIDs.
- Postoperative period after coronary artery bypass grafting.
- Peptic ulcer (exacerbation).
- GI bleeding.
- Intestinal inflammation.
- Heart failure.
- Severe liver failure.
- Renal failure.
- Pregnancy and lactation.
- It is not recommended to use until 18 years.
- Hypersensitivity to the components of the drug and sulfonamides.
With caution, it is worth using the drug with fluid retention in the body, diseases of the cardiovascular system, diabetes mellitus.
Side effects
Despite the high effectiveness of the drug, with prolonged use or non-compliance with the regimen and dosage, side effects from taking Celebrex may occur. Patient reviews indicate the most common (frequent) symptoms, such as:
- Allergic manifestations: rash, urticaria, pruritus.
- Flatulence, dyspepsia, swelling, insomnia.
- Cough, rhinitis, flu-like reactions and respiratory infections.
- Urinary tract infections.
Much less common is increased anxiety, anemia, tinnitus, hot flashes, arrhythmia, arterial hypertension. In some patients, the formation of ulcers in the digestive tract, angioneuropathic edema, the formation of bulla on the skin, exacerbation of pancreatitis or its development, confusion were recorded. All these symptoms can occur only with a short course of treatment (up to 12 weeks, in a dose not exceeding 800 mg). But in the case of prolonged therapy (up to 3 years) are observed:
- Common: stool disorder, hypertension, ear infections, angina pectoris, myocardial infarction, nausea, dysphagia, prostatitis, increased creatinine.
- More rare: arrhythmia, angina pectoris, ischemic stroke, atherosclerosis, sleep disorder, vaginal bleeding, oral ulcers, dysmenorrhea, increased hemoglobin, decreased hematocrit.
Drug Interactions with Other Drugs
The drug is actively biotransformed with the participation of P450 2C9 (cytochrome). Therefore, direct interaction of the drug with other means is possible:
- The simultaneous use of the drug "Warfarin" increases the risk of fatal bleeding.
- The drug "Ketanazole" and "Fluconazole" increase the concentration of the active substance celecoxib almost twice.
- Taking ACE inhibitors or angiotensitis blockers with NSAIDs can significantly reduce their antihypertensive effect.
- The combination of drugs that contain lithium can significantly increase its level in the blood.
- It is forbidden to simultaneously use the drug “Celebrex”, analogues containing celecoxib, with other NSAIDs!
Analogues of the drug
It is worth noting that the drug "Celebrex" does not cost too much, its price on average is from 400 to 450 rubles. for 10 capsules (dosage of 100 mg). However, with prolonged therapy, such treatment is quite expensive for the patient. In this case, by agreement of the doctor, celecoxib-containing products are prescribed. For the drug "Celebrex" analogues are as follows:
- drug "Ranselac";
- medication "Revmoxib";
- Phlogoxib tablets;
- capsules "Artoxib".
These analogs contain the same active substance and have an almost identical therapeutic effect in the treatment of diseases. Note that an adequate dose of the analogue is also prescribed only by the attending physician. At the same time, the doctor takes into account the different composition of auxiliary agents in analogues, they contain different additives compared to the Celebrex drug. Instructions, reviews of doctors indicate the possibility of an allergic reaction on the part of the patient to excipients of various medicines of the same group.