In the instructions in the description of Hypothiazide tablets, the manufacturer indicates that this agent is based on hydrochlorothiazide and has a pronounced effect on high blood pressure. Reasonable use of the drug helps to normalize indicators and bring the patient's condition back to normal. Hypothiazide is also used for gestosis and edematous syndrome, some forms of diabetes and glaucoma. When prescribing the drug, the doctor must explain to the patient at the reception what “Hypothiazide” helps in a particular case. For example, it can be chosen as a means to prevent the formation of stones in the urinary organs.
Features of the tool
The instructions for the use of the drug "Hypothiazide" indicate that the drug is based on hydrochlorothiazide. One tablet contains from 25 mg of this compound to four times more volume. Also used auxiliary components that ensure the stability of the composition throughout the shelf life. The manufacturer in the instructions indicates the inclusion in the preparation of talc and starch, lactose and gelatin, magnesium stearate. Particular attention should be paid to those suffering from hypersensitivity or intolerance to any substances used in the pharmaceutical industry. In particular, the negative effects may be associated with the use of tablets with lactose intolerance.
The drug is available only in tablet form. In the instructions for the use of tablets "Hypothiazide", the manufacturer indicates that the drug belongs to the class of thiazide diuretics.
When will it help?
The indications listed in the instructions for use of Hypothiazide include edematous syndrome. This often persecutes people suffering from diseases of the heart and blood vessels, liver, kidneys. Edema is possible shortly before the onset of menstrual bleeding or under the influence of medications. So, correction of the patient's condition with the help of diuretics is often required if corticosteroids are prescribed.
In the complete instructions for "Hypothiazide", the manufacturer also indicates the effectiveness of the drug with increased pressure in the arteries. The tool can be used both in the form of the main one, but in combination with other drugs to control pressure.
With polyuria, the drug in question is suitable for relieving symptoms. The substance produces an effect based on a paradoxical mechanism. The most pronounced is observed in people with diabetes insipidus. Also, the use of tablets helps to reduce hypercalciuria.
Is it possible or not?
Studying the instructions for use and the description of "Hypothiazide", it is necessary to pay attention not only to the indications for taking the tablets, but also to contraindications. Neglect of these restrictions leads to serious consequences - negative side effects and inefficiency of the therapeutic course.
It is forbidden to use tablets if hypersensitivity or immunity of any of the compounds present in the drug is established. This applies to the main component, and additional substances. You can not use "Hypothiazide" with hypersensitivity to other drugs from the class of sulfonamides.
You can not use "Hypothiazide" with anuria and creatinine clearance of less than 30 ml per minute, with liver failure. The drug is not suitable for correcting the condition of patients who have a lack of potassium or an excess of calcium, which are not amenable to treatment with medications. You can not use the drug for refractory lack of sodium. In the instructions for use and annotations for “Hypothiazide”, the manufacturer indicates the inadmissibility of taking pills for gout.
How to use?
The manufacturer in the accompanying documentation indicates the need to select the optimal dosage individually, taking into account the reaction of the patient's body to drug therapy. It is necessary to regularly monitor the condition of the patient. The composition indicated in the instructions for use of “Hypothiazide” begins with hydrochlorothiazide, which provokes an increased activity of the process of washing out magnesium, potassium from the body. This obliges to regularly take tests of the patient’s biological fluids to clarify the content of trace elements, and resort to replacement therapy, if necessary. More often, such a practice is necessary for patients suffering from heart failure, as well as a weakening of liver function. Increased risk of leaching too sick an amount of magnesium, potassium, if Hypothiazide is combined with digitalis preparations.
The instructions for use of "Hypothiazide" indicate that tablets should be consumed after meals.
Diagnoses and Dosage
With edematous syndrome, an adult patient is initially prescribed 25-100 mg of the drug per day. A possible reception format is every other day. Based on the results, the dose is reduced or increased. Supporting amounts are 25-50 mg per day. With severe symptoms, at first it is possible to prescribe 200 mg. With edema before menstruation, you should use the drug in an amount of 25 mg, taking the drug, the swelling barely started to bother, and completing the course as soon as the bleeding began.
In the instructions for use of "Hypothiazide", the manufacturer indicates that with high blood pressure, the drug is prescribed in an amount of 25-100 mg per day. All prescribed volume is taken at a time. You can use the medication as the only one in the fight against hypertension, you can combine it with other means to correct the condition.
There are cases when at first 12.5 mg of the drug is sufficient. More than 100 mg should not be consumed per day. The optimal format of treatment is the choice of the minimum effective dose, with which it is possible to achieve the effect, as well as the minimum volume, allowing to maintain it constantly.
When “Hypothiazide” is combined with other drugs to lower the pressure, measures should be taken to prevent a sudden sharp drop in pressure. The likelihood of such a phenomenon is more characteristic of the moment when two funds are just beginning to be taken together. To avoid negative consequences, dosage should be reduced.
The instructions for "Hypothiazide" in the reviews on the use of tablets indicate that a pronounced effect on pressure is observed on average four days after the start of the course, but a stable result is achieved only by the end of the first month. The manufacturer also notes that after the completion of the therapeutic course, the effect lasts about a week. This is confirmed by the experience of patients using the described tablets.
Destination Nuances
The manufacturer’s instructions for use for “Hypothiazide” indicate that with diabetes insipidus, the drug can be used to smooth out polyuria. Normally, 50-150 mg are prescribed per day. The dosage chosen by the doctor is divided into several doses.
If necessary, the prescription of the drug for children aged 2-12 years, take into account that on average 1-2 mg per day per kilogram of weight is sufficient. An alternative calculation formula is 30-60 mg per m2. For a day, 37.5-100 mg are used at a time.
Is it worth taking?
According to reviews, the price of "Hypothiazide" fully justifies the effectiveness of this medication. Currently, pharmacies ask for about 70-100 rubles per package. Persons treated with this remedy noted that with the correct use and monitoring of progress by the doctor, the medication helped get rid of unpleasant symptoms and stabilize the condition.
Studying reviews, instructions for use of Hypothiazide, the prices of pills in different pharmacies, more and more people come to the conclusion that the drug is effective and safe, so they try to take it on their own without consulting a doctor. This practice most often leads to side effects. To minimize the likelihood of undesirable consequences, self-medication with “Hypothiazide” and any other diuretics (as well as other pharmacy products intended for use only after consultation with a professional) should be excluded. It can be seen from the reviews that more often it was the people who used Hypothiazide without medical supervision that faced negative consequences.
Hypothiazide: analogues
The instructions for the drug in question indicate that the main component that ensures its effectiveness is hydrochlorothiazide. The medicines “Hydrochlorothiazide”, “Hydrochlorothiazide”, “Apo-Hydro” are based on it. Despite the similarity of the instructions for the use of "Hypothiazide" and analogues, it is impossible to independently decide on the replacement of the drug prescribed by the doctor. An unsuccessful choice of an alternative can easily lead to undesirable consequences. In addition, such treatment may be ineffective.
It is worth noting that the instructions for “Hypothiazide” and the drug analogues mentioned above are pretty close: the drugs are prescribed for the same health problems, have a similar mechanism of influence on the human body. This is due to the similarity of the main active substance.
Negative consequences: what is possible?
In the instructions for use of "Hypothiazide" the manufacturer lists the likely (to a greater or lesser extent) the negative consequences of taking the tablets. In particular, the use of the drug is associated with the likelihood of thrombocyte, leuko, neutropenia, anemia and agranulocytosis, but such negative results of the course are quite rare.
The drug in question can affect the concentration in the body of potassium, sodium, magnesium, calcium, can cause glucose to be detected in urine, as well as an increased glycemic level. With an unknown frequency, there is a risk of arrhythmia, hypotension. Very rarely, patients complained that they were sick and dizzy, troubled by convulsions, paresthesias. There are known cases of confused consciousness, loss of ability to navigate in space. With unknown frequency, while taking the drug, patients were drawn to sleep, disturbed by mood swings, increased nervousness, temporary disturbances of the visual system.
As tests show, the use of the described drug is associated with a risk of impaired stool, nausea and vomiting, inflammatory processes in the salivary glands. Sometimes patients complained of dry mouth and constant urge to drink. There is a risk of jaundice, cholecystitis, pancreatitis, pain and cramping in muscle tissue, nephritis and kidney failure, alkalosis, and liver coma. Under the influence of the components of the tablets, there is a risk of a decrease in glucose susceptibility, which in the case of latent diabetes is associated with the danger of acute manifestation of the disease.
There are also known cases when vasculitis, angiitis, distress, pulmonary edema, pneumonitis, anaphylactic shock, epidermal necrolysis, urticaria, purpura, disorders of the reproductive system, exhaustion occurred during the administration of tablets.
Too much!
In clinical practice, there are references to cases of overdose of a diuretic drug. Symptoms indicate dehydration and leaching of electrolytes. The frequency and speed of the heartbeat gets lost, the pressure drops, a shock condition is observed. The patient vomits and feels sick, is drawn to drink, confused consciousness, the patient is weak and complains of dizziness. Muscle cramps, emaciated state, paresthesia, an-, olig-, polyuria are possible. An examination of laboratory samples of liquid reveals a non-standard level of potassium, sodium, and chlorine. Alkalosis and urea redundancy in the circulatory system are possible.
If an overdose is detected, it is necessary to initiate a vomiting reflex. The drug has no antidote. The patient is shown gastric lavage and taking medications to inhibit the absorption process. Activated carbon is effective.
In case of a shock condition, reduced pressure, the introduction of electrolytes, liquids is necessary. Stabilization requires regular monitoring of the content of these substances, as well as renal function.
"Interesting" position
Currently, scientists have limited information about the possibility of using "Hypothiazide" during the period of gestation. The least useful data is about taking the drug in the first three months of pregnancy. There is a certain knowledge base formed in the study of animal reactions, but such information is not enough to assess the risks to which a person will be exposed.
It is known that the active substance contained in "Hypothiazide" is able to penetrate the placental barrier. Use of the drug in the second and third part of the term can cause fetoplacental blood flow interruptions. As a result, the embryo may develop jaundice. An infant is also at risk if the mother used a diuretic. Possible dangers for the child associated with the use of tablets by the mother are thrombocytopenia, an electrolyte imbalance.
It is not allowed to use "Hypothiazide" to eliminate puffiness, high blood pressure, preeclampsia during the period of gestation. There is no positive effect from administration in this condition, but the probability of a reduction in plasma volume and a deterioration in the blood supply to the placenta and uterus increases significantly.
With essential increased pressure in the arteries during pregnancy, the unwound drug is used extremely rarely - only in the absence of an adequate alternative.
During the period of gestation, tablets with hydrochlorothiazide are generally prohibited. When recommending such treatment to the patient, the doctor is obliged to keep up to date with all possible dangers, and also explain why the benefits of therapy are higher than the risks.
Mother and child
During lactation, “Hypothiazide” is incompatible with breastfeeding, since the active compound of the drug is able to penetrate into breast milk. If medication is required and there is no safer alternative, it is necessary to transfer the child to artificial feeding.
You can not use "Hypothiazide" in relation to children under two years of age. In the period of 2-12 years, the drug is allowed, but the dosage is selected individually, taking into account the weight of the patient. For a day, it is calculated as 1-2 mg per kilogram of live weight. An alternative - you can start from the surface area of the body: 30-60 mg are taken for each square meter. The total volume obtained should not exceed 100 mg.
The nuances of using
The use of any means to lower the pressure can cause hypotension. These risks are associated with the therapeutic course of Hypothiazide. To avoid undesirable consequences, it is important to regularly monitor the patient's condition. The use of the drug can cause an imbalance in the balance of salts and water in the body. Only constant monitoring of the condition allows timely detection of signs of such a deviation. The most common reflection of the disorder is vomiting, accompanied by loose stools. In the presence of this phenomenon, it is necessary to check blood samples for plasma electrolytes. Consider that in warm seasons with a tendency to edema in patients, a loss of sodium from the blood is possible, due to the dilution of this fluid.
The use of thiazide diuretics can cause a decrease in glucose tolerance. In some cases, individuals forced to take drugs to control diabetes must adjust the dosage. This also applies to insulin. The latent form of diabetes can manifest against the background of the use of diuretics on hydrochlorothiazide.
Note!
Thiazide diuretics can cause too slow excretion of calcium with urine. A temporary increase in the content of this electrolyte in blood plasma is possible. A significant excess of calcium may indicate latent hyperparathyroidism. The use of "Hypothiazide" must be stopped, then a full-fledged study of the patient's condition is necessary in order to identify the specifics of the parathyroid glands.
The increase in cholesterol in the circulatory system, the concentration of triglycerides in some cases is explained by the use of diuretics. In some patients, the use of the described tablets can cause gout, hyperuricemia.
In case of impaired liver function, with progressive diseases of this organ, diuretics based on hydrochlorothiazide are suspended only under conditions of exceptionally careful, careful administration.Consider that such medications can cause cholestasis. Even a relatively small adjustment to the balance of salt and water can lead to liver coma. The considered tool is strictly prohibited in case of severe liver failure.