Hypertension is a direct threat to human life, therefore, its treatment must be approached carefully and only with the help of a competent doctor. The consequences of high pressure are various lesions of blood vessels, cardiovascular apparatus, brain, etc. In this article we will talk about the drug "Ebrantil". Analogs will also be presented.
pharmachologic effect
This synthetic drug is prescribed during complex therapy in order to relieve high blood pressure in case of hypertensive crises and severe forms of arterial hypertension. The drug balanced lowers systolic and diastolic blood pressure, has the ability to reduce peripheral resistance and does not cause reflex tachycardia.
This medication lowers pre- and afterload on the heart muscle, increases the efficiency of heart contractions, thereby, in the absence of arrhythmia, strengthens the reduced cardiac output. A drug can act both centrally and peripherally. It does not affect carbohydrate metabolism, uric acid level and does not retain fluid in the body. What analogues of Ebrantil exist?
Composition and indications for use
The main active ingredient of the drug is urapidil, propylene glycol, sodium hydrogen phosphate dihydrate, sodium dihydrogen phosphate dihydrate and water are used as auxiliary components. Available in various forms: tablets, capsules, injection.
Solution for injection is intended to stabilize blood pressure during hypertension, as well as during or after surgery. The tablet preparation is prescribed for patients suffering from arterial hypertension for a long-term course. This is indicated by the instruction "Ebrantil". Analogs may be needed if the drug is not suitable.
Contraindications and side effects
Contraindications include individual intolerance to the components that make up the drug. It is also not recommended to prescribe this drug to patients who have galactosemia, absorption disorders, glucose-lactose deficiency. In addition, "Ebrantil" is not prescribed for the following pathologies: aortic stenosis, open botall duct, arteriovenous fistula. Also, this drug is contraindicated in patients with arteriovenous shunt.
It is recommended to prescribe the drug with caution to elderly patients, as well as those with a history of: mitral valve stenosis, pericardial disease, pulmonary embolism, chronic alcoholism, decreased kidney and liver function. Do not practice the appointment of this medication while taking cimetidine. The use of this drug in pediatrics and for lactating and pregnant women is prohibited, since there is insufficient clinical data on the effect of the components of the drug on the children's body. This confirms the instructions for use for the drug "Ebrantil". Analogs can be purchased at any pharmacy.
Dosage and administration
The drug, released in the form of capsules or tablets, is taken one tablet (capsule) during a meal with a small amount of clean water. In order to be able to constantly monitor the level of blood pressure, it is necessary to take the medicine at the same time intervals. The dosage required for therapy is determined only by the attending physician. If the goal of the treatment is to gradually decrease blood pressure over a specific period of time, 30 mg of urapidil is usually prescribed twice a day. For a faster therapeutic effect, it is recommended to double the amount of the drug (60 mg) twice a day. The maximum allowed amount of medication per day is 180 mg. Patients suffering from liver and kidney diseases, it is necessary to adjust the dosage of the drug in the direction of reduction. Capsules and tablets can be used for long-term treatment.
Solution for injection is used intravenously. The introduction of a medicinal solution in the form of a prolonged infusion is also allowed (the patient is in the supine position). The preparation of the infusion solution is carried out on the basis of a 5% glucose solution and 0.9% saline solution. After taking the course of intravenous jet administration, if necessary, therapy can be continued by taking tablets or by administering the drug dropwise. In an acute situation with the onset of a hypertensive crisis, as a rule, 10 to 50 grams are prescribed. medicinal product. If normalization of blood pressure does not occur, you can repeat the drug after 10-15 minutes.
As an alternative way to relieve a hypertensive crisis and severe arterial hypertension, Ebrantil may be administered by continuous continuous infusion. The maximum permitted rate of infusion is 2 mg / min. For maintenance administration, it is recommended to administer the drug at a rate of 9 mg / hour. For a controlled lowering of blood pressure during or after surgery, slow drip or the administration of the drug by continuous infusion using a perfuser is recommended. The maximum recommended duration of administration of the parenteral variety of this drug should be no more than seven days (after this, the appointment of an oral form of a medication or other antihypertensive drug is necessary). We will consider analogues to the Ebrantil medication below.
Overdose
If the dosage of the drug is overestimated, symptoms such as dizziness, a decrease in the reaction rate, and increased fatigue are possible. If you do not adjust the dose of the drug, then the development of conditions such as orthostatic hypotension and collapse is possible. If an overdose occurs when taking tablets or capsules, then it is necessary to rinse the stomach and prescribe enterosorbing agents. With a significant increase in the dosage of this drug, regardless of the form of release, it is necessary to monitor blood pressure. In this case, the patient is recommended to put on the couch and raise his lower limbs. With a strong decrease in pressure, you need to enter a physiological solution of sodium chloride to increase the volume of circulating blood. If these measures do not give a result, then other medications are used to increase pressure. This is confirmed by the tool "Ebrantil" instruction.
According to experts, side effects develop extremely rarely. In isolated cases, the development of the following symptoms was noted: disruption of the cardiovascular apparatus, palpitations, angina attacks, manifestations of orthostatic hypotension, a strong decrease in blood pressure, thrombocytopenia. From the digestive tract: dry mucous membranes of the oral cavity, bouts of diarrhea, vomiting, nausea. Malfunctions of the central nervous system can be expressed in: sleep disturbance, attacks of causeless anxiety, dizziness, headaches, and increased fatigue. An allergic reaction is possible in the form of urticaria, erythema, anaphylactic shock. In addition, there may be other manifestations in the form of: frequent urges to urinate, urinary incontinence, difficulty in nasal breathing, peripheral edema. If unwanted effects occur, you should consult a doctor, as some conditions require discontinuation of the drug or its replacement with another. During pregnancy, Ebrantil can be prescribed only under the supervision of a doctor if vital indications are present. The use of the drug is incompatible with natural feeding, it is necessary to transfer the child to artificial feeding.
Storage conditions
This medication is stored for no more than 2 years, starting from the release date, in a room where the temperature regime does not exceed thirty degrees Celsius.
Drug interaction
The antihypertensive effect of this drug can be enhanced by the joint use of vasodilators or other antihypertensive drugs. In addition, an increased effect on the body can be observed with a decrease in fluid volume (diarrhea, vomiting), as well as with alcoholic beverages. When taking cimetidine amount of active substance urapidil in the blood can increase by 15%. It is not recommended for use with ACE inhibitors, since the data on such combinations are not currently available in medicine.
special instructions
If previously antihypertensive drugs were used in the treatment of the patient, then Ebrantil should be used after a sufficient amount of time has passed for it to begin to act. Accordingly, the dosage of the drug should be adjusted. It should also be borne in mind that a too intense drop in blood pressure often causes bradycardia or cardiac arrest. Elderly patients should be used with caution and small doses should be administered first to test sensitivity to this drug.
Against the background of taking this drug, the development of a long erection is possible. If you maintain an erection for more than four hours, you must consult a doctor for help, otherwise this condition can lead to damage to the tissues of the penis and loss of potency. The medication affects the ability to drive a car or the ability to work with mechanisms of various kinds, so care must be taken.
Ebrantil - analogues
Analogues of the described medication include drugs from the group of alpha-blockers with the same therapeutic effect: “Artesin”, “Doxazosin”, “Terazozin”, “Tonocardin”, “Zoxon”, “Camiren”, “Proporcon”, “Pyroxan”, “Kornam” "And" Doxazosin-Teva. "
"Artesin"
Synonyms and analogues of Ebrantil should be selected by a doctor.
Artesin is a selective competitive blocker of postsynaptic α 1 -adrenoreceptors. Expands peripheral vessels, which leads to a decrease in blood pressure. Urodynamics improves and the manifestation of benign prostatic hyperplasia decreases. It is used as a symptomatic treatment.
"Tonokardin"
This is the equivalent of Ebrantil tablets. A drug from the group of alpha-blockers. Against this background, the tone of the muscles of the vessels decreases, which leads to a decrease in the total peripheral vascular resistance and blood pressure. This reduces the risk of coronary heart disease. Those people whose pressure is normal do not experience a sharp drop.
The Prophet
An analogue of "Ebrantil" in capsules.
It has hypotensive, sedative, anti-withdrawal, antipruritic effects. Blocking of postsynaptic alpha1- and presynaptic alpha2-adrenergic receptors occurs. He has a peripheral and central influence.
The tone of the smooth muscles of the vessels decreases (especially arterioles and precapillaries), as a result, OPSS, blood pressure decreases. Blood supply to the skin, muscles, and mucous membranes improves. The excitability of diencephalic brain structures is suppressed, the tone of the sympathoadrenal system is regulated.
Kornam
It is not difficult to find analogues in Russia for the Ebrantil preparation. Kornam is an effective antihypertensive drug that is used to treat a number of diseases associated with high blood pressure. It also cures disorders of the urogenital function in men.
Patient Reviews
According to patients taking Ebrantil, it had the most positive effect on their well-being, without any side effects. It is especially noted that previous prescriptions of other medicines did not have such a persistent therapeutic effect.
The article describes the use of the Ebrantil preparation. Reviews and analogues are presented.