Allergic reactions occur in people with only a hypersensitive immune system. As a rule, they appear with repeated exposure of the allergen to the body, previously sensitized to it. Such conditions quite often prevent a person from leading a normal life.
To help patients with hypersensitive immunity, pharmaceutical companies began to produce special anti-allergic drugs that significantly improve the quality of life and the patient's condition.
The most popular remedy aimed at combating allergic manifestations is the medication "Desloratadine." Instructions for use, analogues, release form and indications of this medication will be presented later.
Description, packaging, release form and composition
The Desloratadine medication, the instructions for use of which are placed in a pack of thick cardboard, is available in the form of blue round and biconvex tablets. They are covered with a film membrane and have a white core (in cross section).
The active ingredient of this agent is desloratadine. In addition to it, the composition of the tablets also includes additional elements in the form of corn starch, calcium hydrogen phosphate dihydrate, microcrystalline cellulose, magnesium stearate and talc.
As for the film coating, it is made from a dry mixture consisting of polyvinyl alcohol, titanium dioxide, talc, 3350 macragol, dye-based aluminum varnish and yellow iron oxide.
You can buy the medicine in contour packaging and cardboard boxes, respectively.
Pharmacodynamics of the drug
What is an antiallergic drug like Desloratadine (tablets)? Instructions for use indicate that it is a blocker of H1-histamine receptors, which has a long-term effect.
This medication is an active metabolite of loratadine. In its strength of action, it surpasses it by 2-4 times.
The drug in question contributes to the inhibition of a number of allergic inflammation reactions (releases cytokines, chemokines, interleukins and prostaglandin D2).
Anti-allergic tablets “Desloratadine” have anti-edematous and antipruritic effects, facilitate the course of allergies, reduce bronchial hyperreactivity and the severity of allergen-dependent bronchospasm, and also eliminate smooth muscle spasms. The effect of the medication taken orally is observed during the day.
It should also be noted that this drug has no effect on the central nervous system, including at a dosage of 7.5 mg. He has no cardiotoxic effects, effects on the speed of psychomotor reactions and sedation.
Kinetic features
Where is the absorption of Desloratadine? Instructions for use indicate that the absorption of this drug is from the digestive tract.
The lowest concentration of the drug is found in the blood after 35 minutes, and the highest after 3 hours.
The active substance of the drug binds to plasma proteins by 87%. A dosage of 20 mg taken over two weeks does not contribute to the appearance of signs of cumulation.
Eating does not affect the distribution of the drug in the human body.
The drug in question is metabolized intensively. It is excreted together with feces and urine. The half-life of the drug is 20-35 hours.
Indications for use
At what manifestations of an allergic reaction is it necessary to prescribe the drug "Desloratadine Teva"? Instructions for use indicate the following indications:
- chronic course of urticaria;
- hay fever;
- allergic rhinitis year-round.
Contraindications
In what cases is it forbidden to use Desloratadine tablets? Instructions for use (for children, this medication is prescribed only after reaching the age of 12) reports the following contraindications to the drug:
- pregnancy period;
- hypersensitivity to the ingredients of the drug;
- breastfeeding time;
- lactose intolerance;
- malabsorption of glucose-galactose.
Medication "Desloratadine": instructions for use
How should I take this remedy? According to experts, this drug requires oral administration at the same time.
The use of pills does not depend on the use of food. The antiallergic tablet must be swallowed in its entirety.
Adolescents over 12 years of age, as well as adults, are prescribed a medication in a dosage of 5 mg once a day.
As for such a synonym as “Desloratadine Teva”, it is used in the same amount and with the same multiplicity.
The duration of treatment with the agent in question depends on the frequency of manifestation of signs of allergy and the course of the disease.
As you know, with intermittent rhinitis, symptoms can occur for less than four weeks a year. Therapy of such a disease should be completed only after the disappearance of all its signs. It is advisable to resume taking the drug when they reappear.
As for persistent rhinitis, the symptoms of such an allergy can occur more often than 4 weeks a year. As a rule, the appearance of such reactions is associated with constant contact with the allergen. In such cases, treatment should be continued until contact with the allergen is complete.
Side effects
What undesirable reactions occur while taking Desloratadine tablets? Instructions for use, consumer reviews indicate the following side effects:
- angioedema, headache, anaphylaxis, hallucinations, shortness of breath, convulsions, skin itching, dizziness, rash, insomnia, urticaria;
- drowsiness, tachycardia, psychomotor hyperactivity, palpitations;
- dry mouth, myalgia, abdominal pain, fatigue, nausea, pharyngitis, vomiting, dysmenorrhea, dyspepsia;
- increased activity of liver enzymes, diarrhea, increased concentration of bilirubin, hepatitis.
Overdose cases
What will happen with increased doses of the drug "Desloratadine Teva"? The instruction says that daily use of tablets in an amount of 20 mg for two weeks does not cause any changes on the part of CCC.
It should also be noted that taking the drug at a dosage of 45 mg for 10 days does not contribute to lengthening the QT interval and the appearance of any significant side effects.
Similar means and cost
If there are contraindications for taking Desloratadine tablets, they can be replaced by such means as AlergoMax, Erius, Elyseus, Nalorius, Lordestine, Ezlor, Desal, and Erides. The method of use of such drugs may differ from the method of administration of "Desloratadine." Therefore, they should be prescribed only by an experienced allergist
You can buy the medication in question for 200-320 rubles (10 tablets).
Antiallergic Reviews
Now you know why the Desloratadine medication is needed. Instructions for use of this medication have been presented above.
This drug belongs to the most modern and popular antihistamines.
Patients claim that it is very effective in the treatment of allergic diseases. Taking the pill quickly eliminates nasal congestion.
Also, the medication in question is often used with a combination of rhinitis with bronchial asthma (atopic).
In people with chronic urticaria, it quickly stops all the symptoms of the disease.
Another advantage of this medicine is that it does not have a sedative effect and a negative effect on the heart.