Joint inflammation and related diseases are common ailments. There are several types of drugs used for treatment, and among them is Fermatron. Patient reviews about this medicine suggest that it really copes with the task assigned to it - it really improves joint mobility and relieves pain in them. The article addresses issues related to this drug.
Fermatron: Description
The Latin name for the drug is FERMATHRON. It is a visco-elastic substance that is intended for injection into the synovial space of the joint. It is indicated for a disease called “osteoarthritis of large joints” caused by post-traumatic and degenerative changes.
In the production of this drug, new technologies for the synthesis and purification were used. Due to this, the medicine contains the equivalent of natural human hyaluronan. The substance has effects in the following areas:
- restoration of visco-elastic and protective properties of joint fluid;
- reduction of inflammatory reactions in the joints;
- joint restoration;
- elimination of pain;
- increased joint mobility;
- restoration of homeostasis in the cartilage of the joint;
- stimulation of the synthesis of its own hyaluronic acid.
Composition, release form
The main active ingredient in the drug is sodium hyaluronate. This is a biological analogue of natural hyaluronic acid, which is produced in the human body.
This drug is prepared for release in the form of a one percent sterile clear solution intended for intraarticular administration. The medicine is placed in a syringe made of glass, which is packaged in a blister, and then in a cardboard box. The package contains one syringe intended for single administration. The syringe has a special protective rubber cap and thread for tight connection with the injection needle sleeve . This design eliminates leakage of the drug during administration.
A solution of 2 ml, consisting of the active substance in an amount of 20 mg, which is dissolved in phosphate buffer, is placed in the syringe. The outside of the syringe is treated with ethylene oxide, so it is sterile and completely ready for use.
During a clinical study, it was proved that the drug lacks toxic, mutagenic and allergic properties.
Drug properties
Fermatron, reviews of which are already quite numerous, leaves no doubt about its beneficial properties. It has long been known how important hyaluronate is for the normal functioning of joints. It is proved that it penetrates into the joint cavity, thereby stabilizing the structure of proteoglycans. And this, in turn, gives cartilage elasticity and strength.
In addition, the drug reduces the activity of enzymes that take part in the processes leading to the destruction of cartilage. The medicine also exhibits antioxidant properties and reliably protects joint tissues from the harmful effects of free radicals. The stimulation of the synthesis of its own hyaluronic acid is also important; this has an undeniable positive effect on the musculoskeletal system.
Physically, Fermatron is a substitute for joint fluid with sodium hyaluronic salt in the composition. Since synovial, i.e. articular, fluid serves as a lubricant for the moving parts of the joint, a decrease in its volume in the case of various diseases leads to damage to this organ. In these cases, Fermatron (patient reviews confirm this) restores the lack of joint fluid, thereby relieving inflammation, increased friction and pain, and also improves joint mobility and restores metabolism.
Drug action
The effect of the “Fermatron” preparation is explained by physicochemical properties and biocompatibility, since the medicine contains human-equivalent hyaluronan. This substance is a high molecular weight polysaccharide. It consists of repeating disaccharide residues of glucuronic acid and N-acetylglucosamine, which are components of the joint synovial fluid. The substance is synthesized by fermentation of Streptococcus equi and then thoroughly cleaned. Hyaluronan acts as a kind of shock absorber under the action of direct loads on the joint and lubrication under loads from the side. It also stimulates synovial cells, acting as a filter that does not allow molecules and cells that damage cartilage to pass through.
A clinically reliable result is obtained by Fermatron (patient reviews also confirm this) after the fourth or fifth injection. The effect of the treatment lasts up to six months, sometimes more, after the last injection.
When is the medicine used?
The use of the drug is indicated mainly in the treatment of arthritis and arthrosis. In addition, Fermatron is able to quickly stop the pain, as well as relieve inflammation caused by trauma or degenerative processes inside the joint. It is possible to use this medication with stiff mobility of the knee and other joints.
The drug is also used for any stages of osteoarthritis, as well as after arthroscopic interventions.
Today, doctors quite often prescribe Fermatron Plus. Reviews of patients indicate that it really helps to eliminate and alleviate the main manifestations of certain diseases.
"Fermatron": instructions for use, reviews
The first thing to remember is that this drug can not be used on its own. Dosage, schedules for injections and their number can be prescribed individually only by a doctor after a preliminary examination and determining the degree of articular changes. And the procedure must be carried out by a specialist in view of the fact that it is associated with direct implantation in the joint. You can give injections on an outpatient basis and at home, having invited a qualified medical professional for this.
With a moderate course of the disease, as a rule, up to four to five injections are prescribed, which are carried out once a week. An injection is made with a sterile needle of the appropriate size after pre-treatment of the skin with an antiseptic. The medicine should have room temperature, its remains are not used in the future and disposed of together with the syringe and needle.
If there is exudate inside the joint, it must be removed before injection. The effect of the drug occurs after the first injection.
Contraindications
You can not use "Fermatron" (doctors' opinions in this are unambiguous) if the following conditions are observed:
- violation of the integrity of soft tissues and skin in the joint;
- stagnation of lymph or blood in the joint space;
- significant inflammation and joint infections;
- treatment of juvenile patients;
- acute synovitis;
- increased immunological response of the body to any of the components of the drug;
- pregnancy and feeding - studies on the effect of the drug in these cases have not been conducted. Possible appointment after consulting a doctor.
Side effects
After the Fermatron drug is introduced into the joint cavity (there are almost no patient reviews on this topic), a sensation of warmth, redness, and swelling may develop. Post-injection edema and passing pain may also disturb, rarely, inflammatory processes. In such cases, a ten-minute application of a cooling compress to the joint is allowed.
Most often, such phenomena are short-lived and pass on their own, without additional therapeutic procedures. An allergy to the drug is extremely rare.
Fermatron: reviews and how it is transferred
The use of hyaluronic acid preparations for intraarticular treatment in modern medicine often avoids serious complications and more complex types of treatment.
Sometimes, after the first pair of injections, anxiety, discomfort and a feeling of stiffness appear, but this quickly passes. And after completion of the course of treatment, not only unpleasant manifestations disappear, but also the symptoms of the disease. So not very pleasant injection sensations pay off with more than the effect of the drug.
The price of the Fermatron drug, patient reviews confirm this, is relatively high (about 5 thousand per injection, plus or minus 200 rubles, depending on the pharmacy network and the city), but the cost of injections is worth it.
Almost everyone who used this medicine for treatment noted a quick return to an active life, an almost instant disappearance of pain. Often the use of this drug gives a delay or completely postpones surgery for endoprosthetics.
Precautions and special instructions
The treatment can be carried out both in a hospital setting and on an outpatient basis, in compliance with sanitary requirements.
During the treatment with Fermatron, the reviews of patients and doctors agree on this, the patient can continue to do everyday business, protecting the injection site, that is, the problematic joint, from static and dynamic stresses.
When prescribing a drug, the potential risk and immunological reactions associated with the introduction of biological material into the human body must be taken into account.
Using the product with damaged packaging is not recommended.
There is no data on whether Fermatron is compatible with other drugs intended for intra-articular injections; therefore, their combined use is not recommended.
Not used "Fermatron C" (instructions for use indicate this) in the presence of autoimmune atologies, for example, ankylosing spondylitis.
Also, the combined use of this medication and painkillers is not recommended.
Analogs and storage conditions
Joint treatment can also be carried out with structural analogues of the Fermatron preparation according to the active substance. Here is a list of them:
- Ostenil (Ostenil) ;
- "Hyalur";
- Ostenil plus (Ostenil plus);
- Suplazin (Suplasyn);
- "Fermathron S" (Fermathron S);
- "Dyurolan" (Durolane);
- “Ostenil mini” or “Ministenil” (Ostenil mini, Miniostenil);
- "Sinokrom Forte" (Synocrom Forte);
- Fermathron Plus (Fermathron Plus);
- "Sinokrom" (Synocrom) ;
- RusVisk (RusVisc);
- "Synvisc" (Synvisc).
Store the drug in a dry, protected from sunlight, place and out of reach of children. Storage temperature should not exceed 25 ° C, the medicine should not be frozen.
Shelf life is three years, after the expiration of the specified time, the use of the drug is excluded. The medicine is subject to prescription.