"Milgamma compositum" is part of a complex of B-group vitamins. The drug is a combination. "Milgamma compositum", like other neurotropic B-group vitamins, can have a beneficial effect on the pathology of the motor and nervous system, degenerative and inflammatory in nature.
Active ingredients: pyridoxine hydrochloride , benfotiamine.
Milgamma. Structure. Description.
The second element is a fat-soluble analogue of thiamine (vitamin B1). B1 performs an important function in carbohydrate metabolism, in the Krebs cycle, with subsequent participation in the synthesis of ATP (adenosine triphosphate) and TPF (thiamine pyrophosphate).
B6 (pyridoxine) is involved in the metabolism of protein and, in part, fats and carbohydrates.
The physiological function of both elements is to mutually enhance the action. Thus, a positive effect on the neuromuscular, nervous and cardiovascular systems. With a deficiency of B6, the Milgamma Compositum quickly enough eliminates the deficiency.
The drug is indicated for neuralgia, facial paresis , neuritis (including retrobulbar), plexopathy, ganglionitis, polyneuropathy (including alcoholic, diabetic), neuropathy. "Milgamma compositum" is also prescribed for lumbar ischialgia, radiculopathy, muscle-tonic syndromes.
Injections of the drug are able to relieve neurological pain.
Inside, the medication is prescribed in the presence of any indications three times a day by dragee. Duration of admission is from a month to one and a half.
Milgamma is intramuscularly administered slowly. With a quick injection, the patient may feel severe dizziness, up to passing out. Heart rhythm disorder, cramps, palpitations may develop.
Severe pain involves daily injections of 2 ml for five or ten days once a day. Then (after alleviating the condition), they either switch to the use of dragees inside, or to a less frequent administration of the solution intramuscularly (two to three weeks, two to three times a week).
The use of the medication can provoke shortness of breath, urticaria, Quincke's edema, acne, anaphylactic shock, increased sweating. In rare cases, tachycardia is noted.
"Milgamma" is contraindicated in childhood, with decompensated heart failure, with hypersensitivity, lactation, in the antenatal period.
In case of an overdose of the drug (dragee), it is necessary to rinse the stomach, conduct symptomatic treatment, take activated charcoal.
The effectiveness of B6 in a therapeutic dosage can be reduced by the drug Levodopa.
When interacting with D-penicillamine, cycloserine, sulfonamides, norepinephrine, epinephrine, the effect of pyridoxine may decrease.
Solutions containing sulfates are able to completely dissolve thiamine. In the presence of products formed as a result of the breakdown of vitamin B, other vitamins are inactivated.
Thiamine is incompatible with mercury chloride, oxidizing components, carbonate, iodide, tannic acid, acetate, iron-ammonium citrate, metabisulfite, dextrose, benzylpenicillin, riboflavin, phenobarbital.
The acceleration of the destruction of the component provokes copper. Thiamine activity also decreases with an increase in pH (more than three).
Many experts consider Milgamma the “zloty standard” in the treatment of diabetic angiopathies and polyneuropathies . Due to the content in the solution for injection of lidocaine, the introduction of the drug is almost painless.
When treating Milgamma Compositum, complete pain relief was noted in 30-60% of cases when taking the recommended therapeutic dosage after six weeks of treatment.