Teveten is an antagonist of angiotensin receptors.
What does this mean? This drug is able to selectively affect angiotensin receptors that are found in the tissues of various internal organs, such as the heart, blood vessels, kidneys, or adrenal cortex. As a result of the action of the drug, a rather strong bond is established, which subsequently undergoes gradual dissociation. Consider the instructions for using this tool, and also study the reviews and find out what analogues it has.
Also on sale is Teveten Plus. Combined antihypertensive drug containing eprosartan and hydrochlorothiazide (thiazide diuretic).
Instructions for Teveten will be presented in this article.
Drug description
The presented drug is taken for arterial hypertension. It contains the active component of eprosartan. His work is aimed at preventing the development or reducing the effect of angiotensin. In addition, the drug presented is able to inhibit the activity of the renin-aldosterone system.
Teveten tablets have an effect in several different directions at once: vasodilating, hypotensive and diuretic. After taking the medicine, a significant decrease in arterial vasoconstriction is observed, along with the general peripheral vascular resistance and pressure formed in the pulmonary circulation.
Among other things, there is a process of reabsorption of fluid and sodium ions within the proximal segment of the tubules in the kidneys. In addition, there is a release of aldosterone. Due to the long-term use of the medication presented, there is a significant suppression of the proliferative effect of angiotensin on the cells from which the smooth muscles of blood vessels and myocardium are built.
According to the instructions to Teveten, the antihypertensive effect after the first dose of the medicine, as a rule, persists for the next day, and a stable result from the therapeutic course appears after a few weeks.
In this case, there is no violation of the frequency of contractions of the heart muscle. It is important to note that these tablets do not cause the development of any symptoms of orthostatic hypotension after taking the first dose of the drug.
Pharmacodynamics and pharmacokinetics
What does the instruction to Teveten tell us about this? Eprosartan selectively acts on the AT1-type receptor elements that are located in the heart, kidneys, blood vessels, and also the adrenal glands. This active substance forms a strong bond with further slow movement. Angiotensin binds to AT1 receptors in various tissues, causing vasoconstriction along with the release of aldosterone, sodium retention, and hypertrophy of the heart muscle tissue. Eprosartan also inhibits or prevents the effects of angiotensin. This active ingredient suppresses the aldosterone system.
Eprosartan has a hypotensive and vasodilating effect. It causes a weakening of arterial vasoconstriction, contributing to peripheral vascular resistance and pressure in the pulmonary circulation. Also, thanks to it, there is a reverse absorption of sodium ions, and, in addition, fluid in the renal channels. Aldosterone is released. Against the background of prolonged use, the proliferative properties of angiotensin, which can affect smooth muscle cells of the myocardium, are reduced.
Antihypertensive effect may persist for up to 24 hours after taking a standard dose. As for the confident therapeutic effect, it appears on the background of regular intake in fifteen to twenty days without fluctuations in heart rate. It is worth noting that the medicine presented does not cause manifestations of orthostatic hypotension after taking the first dose.
Next, consider the instructions for "Teveten."
Instruction manual
This medication is intended for use in the treatment of hypertension. It should be taken for those patients who do not have any contraindications for this. The medicine is taken orally, regardless of the intake of food. The recommended starting dose is one tablet once a day. This medication is best taken in the morning.
The maximum decrease in blood pressure in a significant number of patients is observed only a few weeks after the start of the course of therapy. It is important to keep in mind that the maximum dose of this medication cannot exceed 1200 milligrams per day. This is confirmed by the instructions for use "Teveten."
In the case of treatment of elderly patients, there is no need to adjust the daily dosage of the drug. The same applies to the implementation of therapy for people with severe impaired liver function.
Release form and composition of funds
People suffering from moderate renal failure, you need to select a daily dose that will not exceed 600 milligrams. The duration of the course of treatment is determined by the doctor, which directly depends on the reaction of the body to the administered medicine.
As indicated by the instructions for use, Teveten is produced in the form of oval tablets that have biconvex sides. These tablets are white-tinted and film-coated. They include the following chemically active components:
- The main active ingredient is eprosartan mesylate.
- Excipients are lactose monohydrate along with microcrystalline cellulose, pregelatinized starch, magnesium stearate, crospovidone, previously purified water, macrogol, titanium dioxide, hypromellose and polysorbate.
Drug Interactions
According to the instructions for use, Teveten (600 mg) may interact with other drugs:
- The combination with the active substance of the agent described by us does not affect the pharmacokinetics of the drug Digoxin, but also on Warfarin or Glibenclamide.
- From the combined combination of this drug with Ranitidine, Fuconazole and Ketoconazole, there are also no changes in its pharmacokinetics.
- The medicine can be introduced into the patient's body in combination with similar thiazide diuretic drugs, and in addition, blockers of the so-called slow calcium channels. In this case, no clinically significant unnecessary reactions are observed. Instead, a mutual enhancement of the hypotensive function is noted.
- The drug can be prescribed in parallel with lipid-lowering medical agents.
- Cases of reversible increase in serum lithium levels have been reported. In addition, toxic reactions are taking place against the background of the combined use of lithium preparations along with AMF inhibitors.
This is indicated in the instructions for use "Teveten plus."
Contraindications
There are many contraindications, in the presence of which you should refuse to take these pills. They are the following factors:
- The presence of individual intolerance to the chemical components that are contained in the composition of the drug.
- The development of arterial stenosis in the only normal functioning kidney.
- Bearing a child.
- Breastfeeding.
- The development of bilateral stenosis of the arteries of the kidneys, which has hemodynamic significance.
- The presence of an increased sensitivity of the body to lactose.
- Not enough lactase in the body.
- The development of glucose malabsorption syndrome.
- The minor age of the patient.
In addition, Teveten should be taken with extreme caution in the following diseases:
- The development of severe heart failure in severe form.
- The manifestation of pronounced symptoms of renal failure, having any degree of severity.
- Excessive decrease in the amount of blood circulating through the blood vessels.
This is confirmed by the instructions for use. Reviews and analogues to "Teveten" are presented below.
As for pregnancy, these pills should not be taken during this period. If necessary, it is recommended to choose a safe drug-analogue. The active substance can be excreted in breast milk, in connection with this, women need to refuse to breastfeed during lactation.
Possible side effects while taking
According to the instructions for use and reviews of Teveten, taking these tablets can sometimes cause various side effects associated with a specific reaction of the body to the medicine. Thus, the occurrence of the following manifestations is not excluded:
- The appearance of symptoms of asthenia.
- Improper use of Teveten may cause headaches. Dizziness is not excluded.
- Significant decrease in blood pressure values.
- The skin can be covered with a rash. In addition, an unpleasant itch is likely. This is confirmed by the instructions for use and reviews of "Teveten."
- The formation of angioedema.
- Malfunctions in the normal functioning of the digestive system.
- The presence of hypersensitivity to the described drug can cause a weakening of the protective functions of the immune system.
- The appearance of a pronounced violation of the normal functioning of the kidneys with different manifestations.
- The risk of stenosis of the arteries of the kidneys.
What else describes the instructions for use? The Teveten's analogs should be selected by the doctor.
Drug overdose
Symptoms of an overdose are dehydration along with an electrolyte imbalance, manifested in the form of nausea, and, in addition, drowsiness. In addition, blood pressure can drop sharply.
Depending on the time elapsed after taking Teveten, overdose treatment involves the use of enterosorbents along with gastric lavage. Against the background of pronounced arterial hypotension, the patient should take a horizontal position, slightly raising his legs. If necessary, plasma-infused fluid is infused. In addition, supportive and symptomatic therapy is recommended. The use of hemodialysis in this case is recognized as ineffective.
This indicates us instructions for use. We will also review reviews about Teveten Plus.
special instructions
Immediately before the start of the application, and, in addition, periodically as part of the treatment course for patients suffering from renal failure, it is necessary to monitor the functional work of this body. In the presence of the slightest deterioration in the work of the kidneys, it is necessary to determine once again the advisability of taking the drug.
With the combined use of Teveten with potassium-sparing diuretics along with food additives or salt substitutes and other medical devices that can increase the serum potassium content, an increase in this element in blood serum can be noticed. Monitoring of this indicator is required in patients who are at risk. According to the instructions, this drug cannot be used together with angiotensin-converting enzyme inhibitors in patients with diabetic nephropathy.
Double blockade of the angiotensin system through the combined use of enzyme inhibitors or aliskiren is not recommended, as this can lead to the development of arterial hypotension along with hyperkalemia and impaired renal function, including acute organ failure. In situations where a double blockade is necessary, it should be carried out under the strict supervision of a doctor who must constantly monitor kidney function, and, in addition, blood pressure and electrolyte content.
Against the background of primary aldosteronism, the use of the drug "Teveten" and "Teveten plus" is not recommended by the instruction. During the period of therapeutic treatment when driving, and, in addition, when performing any dangerous types of work, caution is advised. This is due to the possibility of developing weakness or dizziness. In the instructions for use with Teveten analogues, you can find similar information.
Duration and storage conditions of the drug
The medication presented is required to be stored in a dry place, which should be well ventilated, at a moderate temperature. This medicine must be hidden from young children. The shelf life of the drug is three years.
Cost of medicine
In Russia, the cost of the drug ranges from seven hundred to two thousand rubles. It depends on the region and the pharmacy network.
Analogs of Teveten
Nowadays, such analogues of the medication as Naviten, Eprosartan and Eprosartan Mesylate are very often used. A suitable analogue should be prescribed exclusively by the attending physician. It is not recommended to self-medicate in order to avoid negative consequences for health and well-being.
Now consider the analogs of Teveten Plus.
These include Bisangil, Aritel Plus, Adelfan Ezidreks, Akkuzid.
Now we’ll get acquainted with the reviews of people who happened to take the Teveten drug.
Reviews about Teveten and Teveten Plus
Reviews about this drug are mostly positive, for example, it is reported that, despite a large list of side effects, in practice, many people have not observed such. Patients write that the result against the background of treatment with this drug was noticeable almost immediately.
Those to whom the doctor prescribed Teveten for the treatment of arterial hypertension report that at first they experienced dizziness, which passed after a couple of days.
Men taking the medication report that contrary to the belief that all drugs that lower blood pressure also lower potency, they cannot say this about these pills.
Some note that two years after taking Teveten Plus, this remedy ceases to help, as a result of which the pressure begins to rise again, so over time, a replacement of the drug is required.
Conclusion
Thus, Teveten is today a very popular drug for the treatment of hypertension. Take this medicine is recommended only as prescribed by your doctor. During pregnancy, this tool should be taken only in extreme cases, and it is better not to use it at all, choosing an alternative analogue. In any case, if for some reason an analogue is needed, it will also be better to seek medical attention for his selection. As part of the treatment with this drug in old age, it is recommended to monitor and pay attention to the work of the liver and kidneys.
We reviewed the Teveten tool for use. Analogs of Tevetenu Plus and reviews about it are also presented.