The medicine "Ceftriaxone" is an antibiotic of the third generation cephalosporin group. It is a bactericidal drug. The antimicrobial mechanism of this drug is effective in combating various microorganisms (both aerobic and anaerobic). The product is available in the form of a dry substance for intramuscular and intravenous administration.
The drug "Ceftriaxone" has a high bioavailability, when administered intramuscularly, it can be 100 percent. The maximum concentration is achieved in the blood by the end of the infusion, subject to a dose of 1 g โ150 ฮผg / L. A stable concentration of the drug is found in the blood by the fourth day.
Ceftriaxone has good penetration into tissues and body fluids. About 95% of the drug binds to proteins. 60% of the drug is rapidly excreted through the kidneys, the rest - with bile into the intestine, where it passes into a state of inactive metabolite.
The medicine "Ceftriaxone." Indications
- Any infectious diseases caused by microorganisms that are sensitive to this drug: peritonitis, meningitis, sepsis, pneumonia, bone infections, pyelonephritis, lung abscess, infected wounds, burns and others.
- Also used to prevent infection after surgery.
Means "Ceftriaxone". Dosage
The drug is intended for i / m and iv. For infectious diseases of moderate severity, it is administered once every 24 hours, one or two grams. In diseases with a severe course, the dose increases to four grams per day.
In the treatment of gonorrhea, the drug is administered once a / m in an amount of 250 mg.
As a prophylaxis of complications after surgery, an hour and a half before surgery, 2 g of the Ceftriaxone medication is administered.
Side effects of the drug must be considered at each appointment. It is advisable to make a test for sensitivity to the drug.
The daily dose for newborns should not be more than 50 mg / kg of the weight of the child. For children from two months to twelve years, a single dose per day is in the range of 80 mg / kg. It rises with meningitis to 100 mg / kg per day. During pregnancy or lactation, the use of the drug "Ceftriaxone" is possible. Side effects, however, say that this should be resorted to only in extreme cases, when a positive result in the treatment of the mother is many times higher than the risk to the child or fetus.
The duration of the course is determined by the attending physician. It must be remembered that patients with impaired renal function need correction in the dosage regimen.
Means "Ceftriaxone". Contraindications
- Hypersensitivity to antibiotics - cephalosporins, carbapenems, penicillins.
- Hypersensitivity to other components of the drug.
- Pregnancy, especially in the first trimester.
- Lactation.
The drug "Ceftriaxone." Side effects
- Allergic reactions: the development of urticaria, fever is possible, anaphylactic shock is extremely rare .
- Dysbacteriosis, diarrhea, vomiting, nausea.
- Candidiasis, stomatitis, glossitis.
- On the part of the blood: thrombocytopenia, neutropenia, eosinophilia, leukopenia, granulocytopenia.
- Others.
Prescribing the medicine โCeftriaxoneโ, it is necessary to remember its features of interaction with other drugs. It significantly enhances the action of aminoglycosides. In combination with non-steroidal anti-inflammatory drugs, as well as with other platelet aggregation inhibitors , it increases the risk of bleeding. Care should be taken in the treatment of kidney disease with the help of the drug "Ceftriaxone". Side effects can be expressed in nephrotoxic effect, especially when taken with "loop" diuretics.
It is forbidden to mix solutions of this drug or to make simultaneous administration together with any antimicrobial drugs or their solutions.
Take only as directed by your doctor.