A cold always creeps up at the wrong time, but as soon as its symptoms appear, urgent measures must be taken so as not to get even more ill. "Coldact" (reviews speak of its effectiveness) is always one of the first to come to the rescue. It will relieve chills, pain, eliminate a runny nose, swelling and minimize all symptoms of the disease.
Composition, release, form
"Coldact" refers to a combined synthetic prolonged drug. It contains such active substances as:
- phenylpropanolamine hydrochloride;
- chlorpheniramine maleate;
- paracetamol.
“Coldact Plus”, reviews of which are mostly positive, has various forms of release. It is sold in the form of capsules, tablets, syrup and powder. Each type of drug requires a certain dosage, its intake should be prescribed and controlled by a doctor.
So, the capsule is enclosed in an aluminum blister and contains 8 mg of chlorphenamine maleate, 25 mg of phenylephrine hydrochloride and 200 mg of paracetamol. It contains not only active substances, but also auxiliary components. The latter include: talc, ethyl cellulose, hypromellose, diethyl phthalate, dyes, povidone, purified water, sodium disulfite, sucrose, starchy ingredients.
The capsule shell contains gelatin, water, methyl parahydroxybenzoate, propyl parahydroxybenzoate, and colorants.
Capsules are in the form of gelatin pills, divided into a red and transparent part, contain white, yellow, orange and red pellets. They are aimed for a long period of action, since microbeads, getting into the gastrointestinal tract, dissolve gradually in it. This process extends the effectiveness of the drug to twenty-four hours. In total, the aluminum blister contains ten pills, and the reception is designed for 5-10 days.
The suspension acts, unlike capsules, much faster, but is not designed for prolonged exposure. Its effect lasts for four hours. The content of active substances in the suspension is much lower than in capsules, therefore, the drug should be consumed more often, namely 3-4 times a day. A 60 ml bottle lasts for two days.
Coldact powder and tablets have a lower price than capsules, but are not as effective. The number of tablets that you need to take per day with the disease reaches twelve, which is not very convenient and not very useful for the stomach and intestines. The powder is used to treat colds in children who refuse to take pills. It is bred in any drink, whether it is milk, juice, water and so on.
"Coldact": pharmacological action
The drug "Coldact", which is rated as an effective antipyretic, vasoconstrictor and antiallergic drug, shows such properties due to the presence of such substances as paracetamol, chlorphenamine maleate, phenylephrine hydrochloride. Designed to eliminate the relief of symptoms of acute respiratory infections and colds.
Paracetamol is an anti-inflammatory drug. It is used mainly for acute respiratory viral infections, namely for inflammation of the mucous sinuses of the nose, larynx, bronchi, and the like. Relieves pain, inflammation, swelling, redness, knocks down the heat.
Chlorphenamine has an anti-allergic effect, removes tearing, itching, pain in the sinuses and eyes. Phenylephrine constricts blood vessels, reduces and removes edema, reduces hyperemia of the upper respiratory tract and nose.
Indications and contraindications to the use of the drug
"Coldt Flu Plus", reviews of which are simply wonderful in terms of eliminating and treating the symptoms of the common cold, is indispensable during the flu, SARS, and acute respiratory infections. Take it and with pain and febrile manifestations, rhinorrhea.
Contraindications to the use of the drug "Coldact" (reviews and instructions for use - confirmation of this) are several factors:
- sensitivity to the ingredients that make up the drug;
- allergy to the components of the drug;
- atherosclerosis of the coronary arteries;
- high blood pressure;
- diabetes mellitus of any type;
- excess thyroid hormones;
- glaucoma;
- serious complex diseases of internal organs, namely the liver, kidneys, cardiovascular system, bladder, duodenum;
- ulcer;
- blood diseases;
- children's age up to twelve years;
- lack of glucose-6-phosphate dehydrogenase.
With caution, you should take "Cold Flu Plus", reviews on the tolerance of which are mostly positive, with hyperbilirubinemia, bronchial asthma, pulmonary obstruction. In people with a lack of glutathione, the use of the drug can provoke serious liver damage.
It is worth refraining from using the drug during pregnancy and while breastfeeding.
Instructions for use
As the instructions for use attached to the "Coldact Plus" preparation note, the capsules have a long-lasting effect. They are taken with plenty of water. For adults and children over 12 years of age, the medicine is prescribed one pill every twelve hours, the course of treatment lasts up to 3-5 days.
The suspension immediately before use should be shaken. Assign to adults and children from the age of twelve two teaspoons (or 10 ml) 3-4 times a day, children of the age group from 6 to 12 years old, it is advisable to give medicine one teaspoon (or 5 ml) 3-4 times day.
As an antipyretic drug "Coldact" (reviews of it confirm its effectiveness in the treatment of colds), it is recommended to take no more than three days. If after this time the drug does not help, you should consult a doctor to prescribe another type of treatment.
Side effects from taking "Coldact"
The drug "Coldact", reviews of which indicate that in some cases it provokes an increase in blood pressure, can also cause heart palpitations, drowsiness, or, conversely, sleep disturbance. Sometimes, after taking pills, dizziness, increased nervous irritability, excessive dryness of the eye or nasal mucous membranes, dilated pupil, paresis of accommodation occur. There is also an increase in intraocular pressure, loss of appetite, nausea, abdominal pain, in the stomach. Coldact tablets can cause anemia, quite rarely - fluid retention in the body, allergies in the form of itching, redness, rash, urticaria or angioedema. Thrombocytopenia, leukopenia, and a decrease in white blood cell count are very rare.
A long course of treatment with the drug in isolated cases may be accompanied by hepatotoxic and nephrotoxic manifestations. Methemoglobinemia, thrombocytopenic purpura was recorded.
Drug overdose
With prolonged use of the medicine, an overdose may occur, which in most cases occurs due to the administration of large doses of paracetamol, which is part of the "Cold Flu Plus". Reviews say that when consumed more than 10-14 g, pallor of the skin, impaired sleep and appetite, nausea, and vomiting reflex may occur. The thrombosed period increases. The activity of hepatic transaminases also increases. There is and develops hepatonecrosis, liver failure, pain in the stomach.
The most serious consequence of an overdose is liver failure, which often leads to encephalopathy, turbulent necrosis, metabolic acidosis. Swelling of the brain of the head is provoked and, as a result, death. People who drink alcohol and take capsules can get serious liver damage.
In case of an overdose of the drug, gastric lavage is prescribed every six hours. They recommend taking SH-group donors eight hours after consuming the Coldact Plus medicine. The instruction states that N-acetylcestein is administered no later than 12 hours before the last dose of the drug.
In any case, if you overdose with a medicine, you should not prescribe treatment yourself, but you need to immediately call a specialist.
Reception in conjunction with other drugs
The likelihood of an overdose with the drug "Plus Plus" (the instructions confirm this) increases when taken together with bambiturates, "Difenin", "Carbamazepine", "Rifampicin", as well as "Zidovucin" and other drugs that are inducers of liver enzymes.
Strengthens the effect of the drug "Coldact" and taking simultaneously with it sedatives, ethanol, various groups of monoamine oxidase inhibitors.
The concomitant use of antidepressants can cause fluid retention in the human body, dry mouth and constipation. Glucocorticosteroid drugs increase the likelihood of developing glaucoma.
Paracetamol significantly reduces the effectiveness of uricosuric drugs.
Chlorphenamine in the composition of the drug and when combined with preparations containing furazodide provokes the manifestation of a hypertensive crisis, excessive excitability and hyperpyrexia.
Tricyclic psychotropic drugs at times increase the effect of phenylephrine, and in combination with halothane can lead to ventricular arrhythmias. They reduce the effect of guanethidine, which, in turn, increases α-andrenostimulation of phenylephrine.
What other consequences can this medication cause long-term use? “Coldact Plus” can cause the anticoagulant effect of warfarin and other coumarin group drugs, and also increases the risk of various kinds of bleeding.
Special instructions for the use of the drug
It is not necessary to self-medicate and prescribe the drug "Coldact Plus" on your own. The price (Russia does not produce the drug) is affordable for it, in addition, it is dispensed from pharmacies without a doctor’s prescription. But, despite this, a physician's consultation should be obtained before taking any medications, especially monoamine oxidase inhibitors.
If after using the “Coldact Flu” medication (the instruction, recall, describes in detail its correct reception), chills, fever, high fever are observed, then you should immediately visit a doctor to clarify the course of subsequent treatment. Throughout the entire period of treatment with a drug, it is necessary to abandon the use of alcohol and drugs containing paracetamol. Do not combine medication with sleeping pills and psychotropic drugs.
When examining blood for the amount of glucose and uric acid, a change in indicators is possible when taking the "Coldact" medication. The use of the drug can not be combined with driving a car. It is necessary to refrain from carrying out hazardous activities that require a special concentration of attention and quick reaction.
"Cold Flu Plus": price
Russia imports this medicine from India. The manufacturer is Ranbaxy. The cost of the drug is quite acceptable and varies around 100 rubles of the Russian Federation depending on the place of sale. The drug is dispensed without a prescription and should be stored at a temperature not exceeding 25 ° C for no more than two years.
Available in prolonged-action capsules enclosed in an aluminum blister, Coldact. The photos below indicate this.
Analogues of the drug are the medicines "AntiFlu" and "TeraFlu Extratab." They have similar active ingredients in their composition, but, unlike Coldact Plus, cost almost two times more. Cheaper substitutes for the drug are Rinza, Rinikold, Coldrex and others.
"Credit Plus": reviews
The therapy with the "Plus Plus" medicine, the price of which is quite reasonable, caused a lot of positive feedback. For many, this is a real lifesaver, which allows you to stay in service with the most dynamic lifestyle. The reviews showed that when taking the drug, relief comes on the next day. Some people already ten hours later stop tickling in the throat, runny nose, cough disappears, the temperature drops. They say that if you drink the medicine at the first sign of a cold, then only unpleasant memories will remain of the malaise, and serious consequences can be avoided altogether.
There are people to whom the drug "Coldact" (the price of the medicine pleasantly surprises) did not fit. These people did not see any result, he did not affect the course of the common cold. But there are very few such reviews. Some say that the capsules are ineffective when you are already sick, and note their uselessness at high temperature. Many do not advise resorting to the medicine without unnecessary necessity, since, according to them, it contains too much dose of paracetamol. Many complain that the drug often causes drowsiness, in some cases there was an allergic reaction to the drug.
There is a certain category of citizens who prefer to be treated with already proven drugs, such as TeraFlu or the usual Paracetamol. They do not understand why they should try something else when they have their own proven drugs.
But, despite this, doctors are increasingly prescribing Coldact Plus to their patients during colds, and those, in turn, despite initial doubts, are satisfied with the result.