Today, many have heard about degenerative inflammatory joint diseases. This is one of the fairly common problems that patients come to medical facilities.
Among the drugs that are prescribed by doctors to eliminate the ailment, chondroprotectors are by all means. One of the most effective means of this group are tablets "Don". The reviews of experts confirm that this drug, which has only one active substance in its composition - glucosamine sulfate, has a positive effect on the state of articular cartilage tissue in case of deforming arthrosis.
But this chondroprotector not only eliminates the symptoms of the disease. After the patient has undergone a course of treatment, which included the tablets "Don", experts receive this drug as a tool that contributes to normalizing the process of formation of articular fluid, as well as improving its lubricating characteristics. Such a complex of effects is especially effective in the initial stages of arthrosis.
Dosage form
Dona tablets from joints are produced by the well-known pharmaceutical company Rottafarm (Italy). In addition to this form, the drug is used in the form of a powder packaged in 5 g sachets, as well as ampoules for intramuscular injection (2 ml each).
Pills "Don" are in white cardboard packaging. Their number may be different. So, there are packages with packaging in 60, as well as 180 white tablets, which have an oblong shape and are coated.
Structure
As mentioned above, the active substance that makes up the Don tablets is glucosamine in the form of sulfate. In addition to it, there are additional substances, namely: microcrystalline cellulose and macrogol 6000, povidone K25 and croscarmellose sodium, magnesium stearate and talc.
Mechanism of action
How do they affect the pathology of the pill "Don" in the body? Reviews of experts suggest that the mechanism of action of the drug is due to the presence of glucosamine in its composition. This substance, which is a natural structural component of the cartilage of the joints. In addition, without glucosamine, the synthesis of biologically active substances that ensure the strength of the cartilage itself is impossible.
What else is this element for? Thanks to glucosamine, there is an active growth of connective tissue in the tendons and in the ligaments of the joints.
However, with age, the content of this substance so necessary for our joints begins to gradually decrease. This leads to the fact that after forty years, a person begins to feel disruptions in the functioning of the motor apparatus. He is especially worried about the disruption of the articular surfaces and a decrease in their functions.
Why are Don tablets prescribed? Doctors' reviews confirm that the drug prevents premature cartilage wear. And in those cases when the pathology has already acquired a neglected form, the medicine allows you to restore its tissue.
Tablets included in the group of chondroprotectors compensate for the deficiency of glucosamine in the body, and also stimulate the biochemical processes of hyaluronic acid and the synthesis of proteoglycans in the synovial fluid.
The drug "Don" helps to increase the permeability of the joint capsule. In this case, the physiological and enzymatic processes that occur in the cells of the synovial membrane and articular cartilage are restored. In addition, taking Don tablets allows you to speed up the process of sulfur fixation during the synthesis of chondroitin sulfuric acid, destroy enzymes that cause cartilage destruction, prevent the appearance of superoxide radicals, and also reduce the activity of lysosomal enzymes.
Therapeutic effect
“Dona” - tablets, the use of which allows to reduce joint pain, restore their efficiency and stop the development of deforming osteoarthrosis. The drug stimulates the restoration of cartilage, providing anti-inflammatory, anabolic, anti-catabolic and chondroprotective effects.
How effective is the drug "Don"? Tablets, the use of which is recommended for those patients for whom the doctor has diagnosed arthrosis, act primarily on the cause of the disease. Their reception allows you to gradually, day after day, restore the destroyed joint. Such an action is similar to building a house. For its construction it is necessary to lay a brick to a brick, and as a result the building turns out.
That is why sometimes negative reviews get "Don" pills. The use of the drug should be long. And only after the patient has completed the full course, a positive result will be noticeable. So, a slight decrease in the symptoms of arthrosis when taking Don tablets becomes noticeable only two to three weeks after the start of their administration. And the patient feels the maximum effect only after one to two months. After completing the course of treatment, the result remains for another fifty days.
Application area
The instruction tells in detail about who the Don is prescribed to. It is necessary to begin complex therapy with this drug in those cases when the doctor has established the presence of such ailments:
- arthrosis of the joints or osteoarthrosis;
- chondromalacia of the supraolenic;
- osteochondrosis of the spine;
- periarthritis;
- systemic diseases in which the osteoarticular system is involved in the pathological process.
How do tablets of joints “Don” affect all these pathologies? Both patient reviews and reviews of doctors suggest that this drug is very effective. After all, diseases of a degenerative-dystrophic nature that arise in the joints become the result of metabolic disorders in the tissues. At an older age, these pathologies develop due to the mismatch of physical activity and the resistance of the joints themselves. Gradually, in the cells of the cartilage, which is a kind of natural shock absorber, metabolic disturbances begin. This leads to necrosis and tissue destruction. After that, the bone tissue is erased, since during physical exertion the processes of its growth begin to activate.
A negative process reduces the amount of intraarticular fluid, which served as a kind of lubricant to the joints. A person has pain. Joint dysfunction occurs. The quality of life is declining. Primary osteoarthrosis develops.
The same disease can be secondary in nature. Sometimes osteoarthritis develops in young people. This happens due to injuries or inflammatory diseases of the joint. Such osteoarthritis is quite slow. However, it does not impair joint function (except for the hip).
Pathology is treated with drugs that improve blood circulation, painkillers. Physiotherapeutic procedures are also prescribed. But still, the main drugs prescribed for the pathologies described above are those that affect the metabolism. Their list also includes tablets "Don".
Indications for use, which are indicated in the instructions, as well as clinical trials confirm the high effectiveness of this tool.
This chondroprotector is also used for changes in the spine that occur with osteochondrosis. Don tablets are also effective for chondromalacia of the patella when softening of its cartilage occurs, which is possible after joint operations and injuries. Also, the drug is prescribed for the complex treatment of patients suffering from inflammatory and autoimmune (causing allergies to their own tissues) joint diseases.
For preventive purposes, it also recommends the use of tablets "Don" instructions for use. Reviews of patients after the age of forty and athletes confirm a decrease in pain symptom with significant physical exertion.
Dosage
How to take the drug "Don" (tablets)? The instructions for the drug explain this issue in detail. The dosage of the drug directly depends on the degree and severity of the disease. That is why it should be prescribed by the attending physician. However, in general, tablets are taken orally 1-2 times three times a day and always with meals. The duration of the course can be from one to three months. In each case, the time of admission is prescribed by the attending physician. If necessary, the course of therapy can be increased or decreased.
There were no cases of overdose with Don tablets. However, this is a pharmacological drug, and you should not abuse it. The course of treatment should be based on the prescription of the doctor and clarification of the instructions.
Contraindications
Like all pharmacological preparations, Don tablets are limited in their use. Instructions for use and patient reviews suggest that great caution is required in the presence of hypersensitivity to one of the components and symptoms of allergies.
Do not prescribe tablets to children whose age has not reached 12 years. This is due to the lack of a sufficient number of clinical studies regarding the safety and feasibility of such therapy.
There is no similar data on the terratogenic effects of the drug on the fetus during pregnancy. There is no information about its negative effect on the child during lactation. That is why the use of the drug is prohibited for pregnant and lactating women.
Due to the fact that the composition of the tablets "Don" contains sodium, they are not recommended for those people who are forced to follow a sodium diet. During treatment, the patient also needs to refrain from significant physical exertion.
Side effects
The body of each of us is so individual that no one can say with certainty how we will respond to the introduction of a particular drug. Various undesirable phenomena can also occur when the pharmacological agent “Don” (tablets) is used. Instructions for use warns that sometimes the patient appears:
- nausea;
vomiting
- constipation;
diarrhea
- headache;
- dizziness;
- general malaise;
- allergic reaction
- visual impairment.
In this way, the central nervous system of a person can react to taking the medicine.
special instructions
Pills "Don" with special care should be taken to people suffering from allergies to seafood. After all, the preparation contains glucosamine phosphate, which is extracted from the shells of mollusks. You should not take pills without the supervision of a doctor and those who have a chronic disease like diabetes.
Complex treatment
What else does the instruction tell us about the preparation "Don"? Reviews of the tablets about their compatibility get the most diverse. In some cases, the integrated use of drugs significantly increases the effectiveness of treatment. In others, on the contrary, it will direct the healing process in the opposite direction. That is why complex treatment should be carried out under the direct supervision of a specialist.
So, our medicine knows many drugs whose action is similar to that which turns out to be Don tablets. However, each of these pharmacological agents has its own characteristics. Most often, treatment prescribed by a doctor includes the use of one of the representatives of the group of chondroprotectors and a drug from another category. This approach is understandable. So, “Don” pills will affect the joint from the inside, and another medicine will ensure the supply of nutrients to the area that gets rid of the pathology. This will provide a quick fix for the problem, which will be affected simultaneously from all sides.
Dona tablets are well combined with drugs that are in the NSAID group, as well as with other chondroprotective agents. While taking them with medicines designed to relieve inflammation, there is an increase in the effects of coumarin anticoagulants. Combining Dona tablets with sedatives is possible only after prior consultation with a doctor. Otherwise, it may worsen, as well as the appearance of side effects.
Treatment result
After the therapeutic course, the following is observed in patients:
- normalization of metabolic processes in the affected cartilage;
- the cessation of the development of processes of destruction of the laying of cartilage;
- return to normal levels of synovial fluid;
- reducing the risk of osteoarthritis;
- reduction of pain syndromes;
- normalization of motor functions in problem joints;
- improving the quality of life;
- reduction of treatment costs;
- eliminating the need for surgical intervention.
Benefits of the drug
The effect of the tablets "Don" is positively evaluated by both specialists and patients who took the drug. Doctors often prescribe this remedy, since it is characterized by the following pluses:
- has a high composition efficiency;
- reduces negative symptoms;
- actively feeds cartilage;
- accelerates the regeneration processes;
- has a minimum list of restrictions;
- rarely causes side effects;
- convenient to use;
- can be used together with drugs included in the NSAID group, as well as analgesics;
- can be used for adolescent patients;
- has a large number of positive reviews of specialists and patients;
- retains its therapeutic effect for a long time.
Patient Reviews
Most often, people respond positively to Don tablets. After a course of taking this chondroprotector, many noted a decrease in crunch in the joints. Knees and elbows began to bend and unbend much easier. At the same time, the pain decreased.
People rarely leave negative reviews about the drug. After all, this remedy is quite effective, and side effects from its use rarely occur. However, some patients remain dissatisfied with the result that they received after the end of the therapeutic course. They believed that getting rid of soreness and stiffness of joints would come faster.
It is worth remembering that a decrease in the symptoms of the disease when taking Don tablets is observed only two weeks after the start of the drug. Perhaps, these people before the start of the course, the instruction for the tool, which indicated its cumulative effect, was not sufficiently studied.
Analogs
Joint diseases are very common. That is why pharmacological companies produce a lot of drugs, the impact of which is similar to that of the drug "Don" (tablets).
Analogs receive reviews, as a rule, also positive, and can be considered when included in the course of therapy. Among these drugs are:
1. "Alfluton." Its main component is a concentrate obtained from sprat fish. This remedy is intended to relieve inflammatory processes, as well as eliminate pain. The product is available in the form of a solution, which is used for injection.
2. "Chondrogard". This drug increases the recovery rate of diseased joints and increases their performance. This drug is also used for intramuscular administration.
3. " Unicum". For those who, for whatever reason, don’t tablets are suitable , analogues can always be found on the network of pharmacies. One of the cheapest of them is Unicum. It contains 750 g of glucosamine sulfate. The use of the drug allows not only to prevent the growth of the process of destruction of the cartilage tissue, but also to stimulate its recovery. However, to obtain the effect, the drug will need to be taken for at least six months. With regular use of this analogue of the Don tablets, joint mobility improves. This reduces the need for taking other funds included in the NSAID group. Reception of this tool should be carried out with caution to those who have an increased sensitivity to the substances that make up its composition. Do not prescribe it to pregnant and lactating women.
4. "Sustilak". This is another analogue of Don tablets. In its composition - all the same active substance. The drug is prescribed for primary and secondary osteoarthritis, osteochondrosis, chondromalacia of the patella and shoulder-shoulder periarthritis. Reception is recommended twice a day. The average course is 6 weeks.
It’s not worth choosing the same analogue of the Don tablets yourself. Only a doctor can determine the best drug suitable for treating the joints of a particular person.