In connection with a change in the structure of pathogens of purulent wounds, it became necessary to use effective means of a new generation. Outdated wound healing ointments do not suppress the infection at the proper level. The use of ointments such as Ichthyol, Vishnevsky, Gentamicin, Streptocid, is illegal in modern medicine. These drugs do not have the necessary antimicrobial ability. They do not anesthetize or relieve swelling.
A complete surgical treatment of wounds involves the treatment of injuries. The wound should be “healed” in the shortest possible time. This will significantly reduce the period of therapy and get an effective result. However, most cases of surgical intervention in the healing process of injuries require medical treatment, taking into account the phase of the wound process. Therefore, the selection of a drug that suppresses the pathogen of a purulent process is very important. Wound healing ointments should have an active necrolytic effect, prolonged osmotic activity. In addition, a property of the drugs is needed to slow down the drying of the wound surface, to stimulate the growth of granulations that contribute to the formation of the epithelium.
Modern clinical practice for the treatment of purulent wounds includes wound healing preparations based on polyethylene oxide. The development is based on the use of a combination of polyethylene oxides with different molecular weights. A number of antimicrobial components were introduced into the composition of the new generation ointments: chloramphenicol, dioxidine, metronidazole with chloramphenicol, iodine with polyvinyl pyrrolidone, furacilin, quinifuril. In addition, wound healing ointments contain trimecaine, which has an analgesic effect; metirulacil. The latter has anabolic and anti-catabolic activity aimed at the formation of new cells instead of damaged cells.
Wound healing ointments made on a PEO basis differ from obsolete products by their multifunctional effect. The osmotic effect lasts up to 18 hours. This allows you to make dressings no more than once a day. Another important advantage of polyethylene oxide-based preparations is their extensive antimicrobial activity. The drug Mafenide Acetate 10% should be noted. It is made on a hydrophilic basis and inhibits gram-negative bacteria in wounds .
Despite the frequent use of ointments based on chloramphenicol and dioxidine, the high antimicrobial activity of these drugs persists for more than 20 years. Technological developments of new tools for wound healing are based on the use of nitrofuran compounds. Such funds include: “Quinifuril ointment 0.5%”, “Furagel”. New wound healing ointments of domestic production with nitrofuran compounds showed high clinical activity and antibacterial effect.
In the treatment of wounds with fungal infection, "Iodopyron ointment 1%" is used. It has significant bacteriological activity. It is indicated for patients with extensive burn wounds, pressure sores, trophic ulcers. Nowadays, multicomponent, iodine-containing ointments are produced abroad. They are widely used in clinical practice. These are such drugs as: “Egis” (Hungary), “Zorka form” (Yugoslavia).
The antimicrobial, osmotic activity of ointments on a PEO - base allows you to stop the development of a purulent process in the first four to five days after tissue damage. For the treatment of anaerobic infections, preparations containing nitazole are used. Their action is aimed at combating streptococci, Escherichia coli, spore-forming bacteria, pathogenic anaerobic microorganisms. Based on nitazole, the following drugs were developed: Streptonitol, Nitatsid.
A new generation wound healing ointment has the ability to stop the development of various bacteria. It localizes multiple infections at any stage of the wound process. Timely use of the right product will allow you to quickly eliminate purulent inflammation, as well as prevent it. The use of ointments with wound healing properties with antimicrobial components significantly reduces the treatment time for patients.