Most people, when prescribing a drug by a doctor, are interested in which manufacturer of Actovegin is better. All pharmaceutical organizations that produce this drug carefully monitor the quality of their products.
All products meet certain standards. That is why medical specialists often recommend purchasing a drug based on the financial ability of the patient.
The cost of a medicine depends not only on which country of origin of Actovegin (injections and tablets), but also on the form of release. In pharmacies in Russia, gel, as well as ointments and cream, can be purchased at a price of 160 to 300 rubles.
The drug in the form of a solution is dispensed from pharmacies in ampoules of two, five and ten milliliters. The price of a medicine varies from 500 to 1200 rubles. In many pharmaceutical shops, the drug is the same for the import and Russian prices.
The most expensive form of release are tablets. The manufacturer of Actovegin for ampoules always uses only high-quality raw materials as additional substances.
In the description of the medication, a list of what is included in the tablets is indicated. The positive side of this form of release is the convenience of use and dosing. The price of a medicine starts from 1500 rubles.
Germany - manufacturer of Actovegin
In Austria, from 1996 to 2011, the drug was produced by Nycomed GmbH, which was a subsidiary of a Swiss corporation.
In September 2011, Nycomed was acquired by the Japanese pharmaceutical leader Takeda Pharmaceutical for 9.6 billion euros.
Today, the manufacturer of Actovegin is Takeda. According to reviews in Austria, it is known that the drug is also produced, but already under a different brand. Raw materials for its manufacture are purchased in Australia and France.
The manufacture of the medicine is carried out in accordance with the rules of the international standard GMPE.
Release form
Actovegin is a medication that can improve tissue repair and trophism. Available in several dosage forms:
- Ointment for external use 5%.
- Cream.
- Gel for external use 20%.
- Injection.
- The solution for infusion in a solution of dextrose 4 mg / ml.
- Coated tablets.
In addition to Nycomed and Takada, the drug is produced by the domestic company Sotex. It must be remembered that the country of origin of the original Actovegin is Germany.
Indications
The drug is intended to eliminate the following conditions and diseases:
- Cracks.
- Cuts of the skin.
- Scratches.
- Pressure ulcers (soft tissue necrosis due to constant pressure, which is accompanied by local disorders of microcirculation and nervous trophism).
- Abrasions.
- Soaking ulcers (wound surfaces with a large amount of exudate).
Injection solution is recommended for use in the following cases:
- Brain disorders.
- Traumatic brain injuries.
- Ischemic stroke (violation of microcirculation of the brain with tissue damage, as a result of difficulty or stopping the flow of blood).
- Peripheral vascular disorders.
- Arterial angiopathy (a pathology in which blood vessel damage is observed).
- Trophic ulcers (a defect in the skin or mucous cavity that appears after rejection of dead tissue has a tendency to relapse).
- Diabetic polyneuropathy (a disease that is characterized by a complication of diabetes mellitus and occurs when the glucose level exceeds the norm).
- Wound healing
- Trophic disorders.
- Burns (a violation of body tissues that is triggered by exposure to elevated temperatures or certain chemicals).
- Violation of the healing process of wounds.
- Radiation injuries of the skin and mucous membranes during radiation therapy.
Tablets cope with the following deviations:
- Diseases of the brain.
- Head injury.
- Cerebrovascular insufficiency.
- Peripheral vascular lesions.
- Arterial angiopathy.
- Trophic ulcers.
- Diabetic polyneuropathy.
What limitations does the drug have
According to the instructions for use with Actovegin, the manufacturer warns that the drug is not allowed to be used in the presence of the following conditions:
- Individual intolerance.
- Fluid retention in the body.
- Heart failure.
- Oliguria (a decrease in the amount of urine produced compared to the standard).
- Anuria (a pathological disease that is triggered by various causes, a symptom of which is the cessation of urine into the bladder).
- Pulmonary edema (a serious disease, which is characterized by a massive exit of transudate from the vessels into the interstitium of the lungs, later into the alveoli).
- Hypernatremia (a pathological process that is caused by a deficiency of water in the body, which is accompanied by an increased content of sodium ions).
- Hyperchloremia (a disease in which a person has high blood chlorine).
- Pregnancy
- Heart failure of the second and third degree.
- Hyperhydration (a special form of disruption of the water-salt balance, which is an excessive amount of water in the body or in its individual parts).
- Breastfeeding.
Instructions for "Actovegin"
The method of administration of the solution is intra-arterial, as well as intramuscularly and intravenously. Due to the existing potential risk of anaphylactic reactions, it is necessary to conduct a test for increased sensitivity to the drug before starting the procedure.
Recommended dosing schedule:
- In case of brain disorders, the drug is administered intravenously. Every day for two weeks, 200-1000 milligrams per day, after which the patient is transferred to Actovegin tablets.
- For ischemic stroke, intravenous drip is used, daily 800–2000 milligrams of a solution in sodium chloride 200–300 milliliters in a course of one week. Further, daily dosing should be reduced to 400-800 mg and continue treatment for another fourteen days, after which the patient must be transferred to the use of an oral drug.
- In peripheral vascular disorders, an intravenous or intra-arterial drug is used. Every day, 800-1000 milligrams of Actovegin in a 0.9% sodium chloride solution lasting twenty-eight days.
- In diabetic polyneuropathy, 2000 mg are administered intravenously per day for a duration of twenty-one days. Subsequently, the patient is transferred to the tablet form of Actovegin.
- In the treatment and prevention of radiation injuries of the skin and mucous membranes during radiation therapy, 200 milligrams of the drug is administered intravenously at an average daily dosage in certain intervals of radiation action.
- When wound healing is used intravenously at 400 milligrams or intramuscularly at 200 mg. Depending on the healing, the medicine is used every day or three to four times a week as an addition to the local Actovegin therapy in external dosage forms.
- With radiation cystitis, a medication is used transurethrally 400 milligrams daily simultaneously with antibiotics. The infusion rate of the solution is about 2 milliliters per minute. The duration of treatment is determined by a medical specialist individually and depends on the severity of the disease.
Analogs of Actovegin
Manufacturer - Austria until 2011 - until the moment when it was bought by a Japanese pharmacological organization. The following substitutes are considered generic drugs:
- Solcoseryl.
- "Diavitol".
- "Cerebrolysin".
- Mexidol.
- Cortexin.
- Chimes.
Before replacing the drug, specialist advice is needed. Which manufacturer of "Actovegin" is better?
"Solcoseryl"
Direct analogue of Actovegin. It can be considered the only full-fledged replacement due to the original calf blood extract Solkoseril, which is part of the preparation, produced by the German company Valeant.
In the instructions for use for both medicines, similar pharmacological properties are indicated, as well as indications and side effects. But comparative studies of generics were not carried out, therefore, their bioequivalence has not been officially recorded.
There are differences in products and concentrations of similar forms of the drug. So, in the Solcoseryl line "there is no cream for external application and 10% solution for injection, but an adhesive dental paste is presented.
The solution for injections "Solcoseryl" is produced in the content of 4.25%, and the gel for the skin in a concentration of 10%.
Characteristics of Solcoseryl
The drug, as already mentioned above, is produced in several dosage forms:
- Solution for intravenous and intramuscular injection. This liquid is from light yellow to yellow, colorless, which has a weak specific aroma of meat broth.
- The gel for external use has a homogeneous, almost transparent substance of dense consistency, which has a weak specific aroma of meat broth.
- Ointment for external use. This form of release has a uniform, greasy consistency from milky to white-yellowish, which has a weak specific aroma of petroleum jelly and meat broth.
- Eye gel is colorless or slightly yellowish, of a liquid mass without aroma or with a slight characteristic odor.
Instructions for use "Solcoseryl"
Solution for intramuscular and intravenous administration. Dilution of the solution, depending on the type of injection:
- Intravenous drip: 250 ml of 5% dextrose solution or 0.9% sodium chloride solution.
- Slowly intravenously: in a ratio of one to one using 5% dextrose solution or 0.9% sodium chloride solution. Intramuscularly used without dilution.
Recommended drug therapy regimen:
- In chronic venous insufficiency with trophic disorders, ten milliliters are used intravenously, three times a week. The duration of therapy is no more than one month, the duration is determined by the doctor, based on the clinical picture of the disease. At the same time, it is necessary to simultaneously treat concomitant local trophic tissue disorders using Solcoseryl (gel), and then ointments.
- With peripheral arterial occlusion diseases, 20 milliliters are used intravenously every day. The duration of treatment is up to 4 weeks, the duration is determined by the doctor based on the severity of the disease.
- For disorders of cerebral circulation and metabolism (hemorrhagic or ischemic stroke, traumatic brain injury), 10 to 20 ml are used intravenously for 10 days, then 2 milliliters intramuscularly or intravenously, for up to one month. When it is impossible to use the solution in a vein, it is necessary to administer the drug into the muscle, two milliliters per day.
Cortexin
The drug is produced in the form of a lyophysiate for the manufacture of a solution for injection into the muscle. The medication is available in bottles of five milliliters of ten pieces per pack. The content is a porous milky powdery consistency with a slight yellowish color.
The main active component of the Cortexin preparation is a complex of water-soluble polypeptide fractions; one bottle contains ten milligrams of the active substance. Glycine acts as additional components. The producer - "Geropharm" (Russia).
Under the influence of the drug, the functioning of the brain, as well as memory, improves the concentration of attention and perception of information. When using this drug, a person becomes more susceptible to stress and psycho-emotional overload.
The regular use of this drug has an antioxidant effect on the body, protects cells from the action of free radicals, increases the resistance of nerve cells under stress and oxygen starvation.
"Cerebrolysin"
The main active component of the solution for injection is a complex of peptides that belong to neurotransmitters. It is an analogue of the original ("Actovegin").
Manufacturer - Germany, the company "Ever Pharma" produces a medication. Due to the active component in the composition, the drug exerts several pharmacological actions, which include:
- Increased oxygen utilization by brain cells with improved energy metabolism.
- The drug has the ability to regulate the reproduction of cells of the nervous system, which is similar in effect to the natural factors of neuronal growth.
- The medication protects nerve cells from harmful effects, in particular, with the accumulation of lactic acid in neurons under conditions of oxygen deficiency. In addition, the drug inhibits the formation of free radicals.
- A positive effect on the functional activity of the structures of the central nervous system, thereby improving memory, attention, mental performance.
Since the medication contains a complex of peptides, there is no reliable information on the absorption, distribution through the tissues, metabolism, and excretion of the Cerebrolysin injection solution from the body today.
"Diavitol"
Generic local forms of Actovegin also include the Belarusian drug Diavitol, which is produced by Dialek UE. Its structure includes a deproteinized concentrate from the blood of cow embryos and the blood of young calves.
The drug must be used as a wound healing drug for inflammatory lesions of the skin, as well as mucous cavities, and for trophic ulcers.
The medication is used for the following pathologies:
- Diseases of the organs of vision, which are accompanied by tissue hypoxia.
- Diabetic retinopathy (one of the types of microangiopathy that develops against the background of long-term diabetes mellitus and affects the blood vessels of the retina).
- Long-term non-healing wounds of the skin and mucous membranes, including ulcers of the mucous organ of vision.
- Trophic ulcers of various origins.
- Pressure ulcers (for prevention and treatment).
- Radiation lesions of the skin and mucous membranes.
- The need for a skin transplant.
The drug is contraindicated in case of individual intolerance to any substance.
Side effect:
- Redness of the skin around the site of application.
- Itching
- Hyperthermic reaction (violation of thermoregulation, which appears due to the influence of environmental factors, or violation of the internal mechanisms of heat production, as well as heat transfer).
- Allergic reactions that require intensive treatment.
- Pain in the gastrointestinal tract.
- Nausea.
- Vomiting.
- Loose stool.
- Shortness of breath (one of the adaptive functions of the body, which is characterized by a change in frequency, as well as rhythm and depth of breathing, usually accompanied by sensations of air deficiency).
- Tachycardia (a sharp increase in heart rate, a symptom of serious illness).
- Hypotension (a prolonged pathological condition of the body, which is characterized by a decrease in blood pressure and various autonomic disorders, for example, a decrease in body temperature, as well as sweating of the feet and hands, pallor of the skin).
- Headache.
- Dizziness.
- Impaired consciousness.
- Tremor (fast, rhythmic movements of the limbs, which are provoked by muscle contractions and are associated with a time delay of correcting afferent signals).
- Paresthesia (a disorder of sensitivity, which is characterized by a sharply appearing burning sensation, as well as tingling and crawling creeps).
There is no doubt that in the event of any unpleasant sensations, the administration of the drug should be stopped and symptomatic treatment should begin.
Gel "Diavitol" is applied to the wound surface with a glass rod, which is pre-treated with 40% ethanol or boiling water. First, the wound surface is treated with a 3% hydrogen peroxide solution or a 0.1% aqueous solution of chlorhexidine bigluconate. The course of gel treatment is fourteen days. The drug is advisable to apply before the appearance of granulations.
With the threat of pressure sores, the gel is rubbed into the skin in places of increased danger. It can also be used on the skin between sessions of radiation therapy for prophylactic purposes.
Intramuscularly, the injection solution is administered no more than five milligrams per day very slowly.In order to introduce the drug into the venous bed, it should be diluted in physiological saline or glucose. The recommended concentration is from 20 to 50 milliliters of the product per 250 ml of solution.
Dosage depends on the severity of the disease. As a rule, five or ten milliliters of medication is initially administered intravenously, and then daily intramuscular or intravenous injections of Diavitol are performed. It can be used several times a week.
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Conclusion
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On the Internet there are many reviews of the drug "Actovegin" in which people tell about the effectiveness in the treatment of various diseases. There are different opinions. In some situations, marked improvement in health with neurological ailments.
Certain allergic reactions sometimes appeared. Doctors note in their reviews of Actovegin: the manufacturers of this medicine use raw materials of different quality, hence the difference in price.
But some adults who used this medication to treat children, including newborns, noted that it was difficult for small patients to tolerate injections intramuscularly, since they are quite painful.
There are also many positive reviews about the tablet form of Actovegin. The reviews of medical specialists and people confirm the increased effectiveness of the drug, it eliminates all the negative symptoms of the disease.
Global is the manufacturer of Actovegin, the country that produced the drug before is Germany.