One of the common endocrine pathologies is diabetes. Most patients with this diagnosis suffer from the second type of the disease. The disease requires constant treatment and medication. The drug "Gliclazide" is able to stimulate the production of insulin in the body. Analogues of the drug may have a similar mechanism of therapeutic action or an identical composition. The attending physician should select a substitute for the original medicine.
Description of the drug "Gliclazide"
The drug "Glycliazide" refers to sulfonylurea derivatives (second generation) and has a pronounced hypoglycemic effect. The drug can be used in the treatment of non-insulin-dependent diabetes. The main goal of Glycliazide therapy is to lower blood glucose. Also, carbohydrate and lipid metabolism are normalized . In a pharmacy, you can buy a medicine under the name "Glyclazide-Akos", "Glidiab-MV."
The active substance of the same name positively affects the state of blood vessels, restoring their permeability and preventing the development of atherosclerosis. Long-term medication for diabetic nephropathy provides a significant reduction in proteinuria (the presence of protein in the urine). Against the background of treatment with the agent, the risk of developing parietal thrombosis is significantly reduced.
The maximum concentration of the main active substance in the blood is recorded 6-12 hours after taking the "Gliclazide" tablets. The analogs of the drug have also proven themselves well, but the doctor must individually select them. As part of the original drug, the active ingredient is a modified-release gliclazide.
Indications for appointment
According to the annotation, "Gliclazide" is prescribed to persons with a history of type 2 diabetes (sugar). Pathology differs from the first type in that in the second case, the self-production of insulin by the body is completely stopped. The main reason for the development of the disease is considered to be aging. However, the presence of extra pounds and excessive consumption of carbohydrates in food can also trigger the development of diabetes.
Glyclazide tablets are recommended for use as part of complex therapy for microcirculatory disorders. For preventive purposes, the drug is prescribed to prevent the development of the severe consequences of diabetes: stroke, heart attack, nephropathy, retinopathy.
Contraindications
It is forbidden to take "Gliclazide" (including analogues of the drug) in the presence of the following diagnoses:
- intestinal obstruction;
- leukopenia;
- severe stage of renal, liver failure;
- diabetes mellitus (type 1);
- infectious diseases in which there is a violation of the process of absorption of food;
- paresis of the stomach;
- lactation period;
- age up to 18 years;
- ketoacidosis;
- pathological conditions in which the use of insulin is required;
- pregnancy.
How to take Glyclazide?
The dosage of a hypoglycemic agent is selected individually by a specialist. The daily dose may vary between 30-120 mg of the active substance, depending on the severity of the patient's condition and his age. Take tablets once a day before meals (preferably on an empty stomach).
If you skip taking the medication, increasing the dosage is not recommended. In some cases, the maximum dosage may reach 320 mg.
Features of the use of the drug "Gliclazide"
Analogues of a hypoglycemic agent, like the original drug itself, are used only in combination with a low-calorie diet, which implies the use of a minimum amount of carbohydrates. It is important to control the level of glucose in the blood serum before and after eating. Adjust the dosage of the drug after emotional stress or physical exertion.
The drug can be canceled with fever caused by extensive burns, surgical interventions. With the simultaneous use of Glyclazide and ethanol-containing medicines, non-steroidal anti-inflammatory drugs, there is a risk of hypoglycemia. Ethanol can cause abdominal pain, vomiting, and nausea.
Analogs
Sulfonylurea drugs are considered essential in the treatment of diabetes. Their significant disadvantages include the development of resistance. A similar situation is observed in 5% of patients, who are subsequently transferred to insulin therapy.
The drug "Gliclazide", the price of which ranges from 130-160 rubles per pack (30 tablets), can be replaced with a drug with a similar composition. On the basis of gliclazide, modified release drugs are also produced. The following analogues of the original drug are considered effective:
- Glidiab.
- "Diabeton MV".
- Vero-Glyclazide.
- "Diatics."
- Diabetalong.
- Diabinax.
- Glidiab MV.
- Diabefarm.
Glyclazide-based drugs have a positive effect on microcirculation, hematological parameters, hemostasis system. This is extremely important for patients with type 2 diabetes. The doctor should select medications to stimulate the production of insulin. It should be borne in mind that such a therapeutic effect entails an increase in body weight.
"Diabefarm": instructions for use
The hypoglycemic agent is available in tablet form. One tablet contains 80 mg of the main active ingredient of gliclazide. As auxiliary components, milk sugar, magnesium stearate, povidone are used. The manufacturer - a Russian pharmaceutical company - produces the drug “Diabefarm MV” with a modified release. In these tablets, the dosage of the active substance is reduced to 30 mg. Release occurs within 24 hours.
The dose of the drug is individually selected. The doctor takes into account the level of glucose in the blood serum, the patient's age and the symptoms of the disease. The initial daily dose should not exceed 80 mg. In the future, it is increased to 160-320 mg of gliclazide.
"Diabefarm" application instruction recommends that it is prescribed to adult patients for whom diet therapy and physical activity are not effective. Modified-release (MV) tablets should be taken 1 time per day. Your doctor may increase your dosage after a blood sugar test.
Side effects and overdose
Experts note that side effects associated with taking the medication develop mainly with non-compliance with the dosage and general recommendations regarding complex treatment. Hypoglycemia - one of the common side effects - is accompanied by symptoms such as increased appetite, arrhythmia, heart palpitations, rapid fatigue, drowsiness.
From the digestive tract, the following disorders may occur:
- constipation
- vomiting
- nausea;
- hepatitis;
- diarrhea;
- holistic jaundice.
In rare cases, allergic reactions occur in the form of itching, urticaria, and redness of the skin. Some signs of side effects of the drug require its withdrawal.
Overdose often leads to the development of hypoglycemia, hypoglycemic coma, impaired consciousness. You can restore glucose concentration by intravenous dextrose solution (if the patient is unconscious). In the event that there are obvious signs of hypoglycemia, but the patient remains conscious, he needs to take a small amount of sugar.
The drug "Glidiab"
Another hypoglycemic agent with a pronounced therapeutic effect is Glidiab. Instructions for use indicate that in one tablet contains 80 mg of the active substance of gliclazide. One package contains 60 tablets. The cost of the drug is 110-140 rubles. Glidiab MV, the price of which is 140-170 rubles, is prescribed to patients more often.
The action of the drug is based on the activation of cells in the pancreas that produce insulin. Glidiab is able to restore the first peak of insulin secretion, which distinguishes it from some other agents from the group of sulfonylurea derivatives.
4 hours after taking the medication, the maximum concentration of gliclazide in the blood serum is observed. The drug is absorbed into the gastrointestinal tract almost completely.
Interaction with other medicines
"Glidiab" instructions for use recommends taking caution with simultaneous therapy with glucocorticoids, calcium antagonists, barbiturates, lithium salts. This will cause a decrease in the therapeutic effectiveness of the hypoglycemic agent.
An increase in the activity of the active substance will be observed in the case of a combination of Glidiab with antifungal oral medications, fibrates, indirect anticoagulants, other hypoglycemic agents, and anabolic steroids. Before starting therapy, the doctor should inform the patient about the features of taking the drug.
Diabeton MV
The drug "Diabeton" with a modified release of the active substance belongs to the group of sulfonylurea derivatives of the 2nd generation. A distinctive feature is the presence of a heterocyclic N-containing ring, which has an endocyclic bond. Experts note that when taking the medicine for 2 years, resistance does not develop.
The tool is intended exclusively for the treatment of adult patients, like the original drug "Gliclazide." The price of the French medication is 320-370 rubles per package (30 pieces).
The maximum concentration of gliclazide in the blood is observed 6-12 hours after taking the pill. This allows you to reduce the number of medications per day. Usually, doctors recommend taking 1-2 tablets per day. Specialists and patients leave exclusively positive reviews about the treatment with this drug.
Patients should be aware that lactose is part of the medication. Therefore, it is not recommended to take it with congenital intolerance to this substance or galactosemia.
According to reviews, Diabeton MV is considered one of the most effective agents from the category of sulfonylurea derivatives. A significant advantage is the rare occurrence of side effects while taking the medicine. Only a specialist can determine the dosage and treatment regimen. The patient must first be examined. It is extremely undesirable to take medications on your own to lower glucose.