With bacterial infectious pathologies, specialists are often forced to prescribe antibiotics. However, it is sometimes difficult to identify the type of microorganism, therefore, drugs with a wide spectrum of action are required. Among them, the drug “Azitrox 500” stands out with particular effectiveness, the instructions for which show that it quickly inhibits the synthesis and, accordingly, the multiplication of pathogenic bacteria, destroys pathogens inside and outside the cell. However, it is always necessary to remember that treatment with antibacterial agents is possible only after the appointment of a doctor, since self-medication for any disease can cause significant harm to health.
What is the drug
Azitrox is an antibiotic preparation of a variety of azalides. The number 500, in this case, means that each pill contains a given amount of the active substance azithromycin. There is also the drug "Azitrox 250".
The release form involves capsules, which are packed in cardboard packs containing from 2 to 10 pieces in a blister. A suspension for oral administration also exists. It comes in dark vials from 5 to 20 ml. "Azithromycin" in tablets is presented in the dihydrate format, if we consider the chemical composition of the main active ingredient.
Active and support staff
Capsules, in addition to the active substance azithromycin, contain auxiliary substances:
- mannitol;
- corn starch;
- magnesium stearate;
- sodium lauryl sulfate.
The capsules are enteric coated, which is made by adding titanium dioxide and medical gelatin.
Drug properties
A pronounced bactericidal property has Azitrox 500. The instruction informs the consumer that, using drugs in high concentrations, it is possible to promote rapid inhibition of protein synthesis, suppressing the reproduction and growth of bacteria. Clinical studies and laboratory tests have revealed that the drug actively destroys gram-positive cocci and gram-negative aerobic bacteria. Possible action on some strains of anaerobic pathogens, however, many gram-positive microorganisms show resistance to the effects of this antibiotic.
Drug absorption
Azitrox 500 mg capsules are productively and rapidly absorbed from the gastrointestinal tract into the bloodstream. Chemical analyzes have shown that in plasma the maximum concentration of the active substance is detected two hours after taking one pill. It is known that even after complete completion of the course, the concentration of antibiotic substances in the blood is maintained at a fairly high level for another week.
Metabolism occurs actively in the liver, all inactive substances are excreted by the kidneys, the main part within 14 hours, remaining for 40.
When is it prescribed?
"Azitrox 500" testimony has rigorous and justified laboratory tests. According to them, this medication is recommended for infectious pathologies that were triggered by excessive activity of pathogenic bacteria that are sensitive to the effects of azithromycin.
The following pathologies are considered medical indications:
- inflammatory diseases of the respiratory system such as: bronchitis and pneumonia;
- infectious processes that occurred during sexual transmission;
- infections of ENT organs, which include: sinusitis, pharyngitis, otitis media and tonsillitis;
- diseases of the genitourinary system caused by pathogenic bacteria;
- soft tissue and skin diseases such as erysipelas, migratory erythema, dermatosis and impetigo;
- duodenal and gastric infections caused by Helicobacter pylori.
Despite the clearly indicated indications in the instructions for use, self-medication is prohibited. Only a doctor is able to accurately diagnose and accordingly prescribe treatment.
How to take an antibiotic
"Azitrox 500" instruction suggests drinking in courses that usually last no more than 7 days. It is important not to combine taking pills and food, as this significantly reduces the therapeutic effect and slows down the healing process.
It is recommended to take the capsules, either two hours after the meal, or one hour before meals. Patients especially like that the drug needs to be drunk only once a day. However, it is advisable to observe the principle of the same time, skipping the admission is strictly prohibited.
"Azitroks": instructions for use for children
In pediatrics, a suspension medicine is used. To prepare the dosage form, add 9.5 ml of water to the bottle with the finished powder. Next, the solution is heated and cooled. To get rid of the crystalline precipitate and achieve a homogeneous mass, carefully shake the bottle. A single dose of the drug is 20 ml, which must be washed down with plenty of water. The bottle must be shaken well before each use. "Azitroks" is a suspension for children, which is suitable for treatment, starting from six months and older.
Capsule instructions
Gelatin pills are not chewed, but swallowed whole, washed down with plenty of water. Azitrox 500 mg tablets can be prescribed for serious diseases that occur with complications. A single dosage can be reduced by half. Only a doctor can calculate the required amount of active substance, depending on the age of the patient, the nature of the disease and the characteristics of its course. For a day, it is possible to use no more than 1,000 mg of azithromycin in tablets.
Notes from the annotation
An antibiotic of the macrolide type is unable to inhibit psychomotor reactions and does not inhibit the nervous system, therefore, with this drug, it is not forbidden to work with mechanisms and drive a vehicle.
If the patient has missed taking the next dose of the medicine, it is necessary to take it as soon as possible. And the next pill is drunk after 24 hours.
Use during pregnancy
"Azitrox 500", instructions to confirm this, can be used in the treatment of expectant mothers, however, only a doctor can determine that such treatment will not harm a pregnant woman and will not adversely affect the development of the fetus. A single and daily dosage of the medication is selected only individually. Treatment is carried out under the strict supervision of a specialist. If you need to use pills during lactation, it is important to temporarily stop breastfeeding and use artificial mixtures.
Pediatric Use
Admitted in pediatric practice, "Azitroks". Instructions for use for children involves the use of both capsules and suspensions. However, according to the annotation, tablets are not recommended for patients under 12 years of age. Further, the doctor may prescribe "Azitrox 250", while the daily dose is calculated based on the weight of the patient. For one kilogram once a day, you need to drink 10 mg of azithromycin. The treatment regimen involves therapy for three days.
For smaller patients, a suspension that has a pleasant fruity taste, but requires the special preparation conditions described above, should be chosen.
Combination with other medicines
"Azitrox 500 mg" is often prescribed as part of complex therapy. The instructions spell out recommendations for interaction with other drugs:
- "Azitrox" is not recommended to be taken together with cycloserine, because its toxicity increases;
- ethanol, food and antacids slow the absorption of the antibiotic into the bloodstream;
- "Azithromycin" increases the concentration of digoxin in the blood;
- the anticoagulant effect of "Warfarin" is enhanced;
- “Azithromycin” has no effect on theophyllines, carbamazepines, and triazolams.
It is strictly contraindicated to combine azitrox and alcoholic beverages, otherwise persistent signs of severe intoxication of the body occur. It is also forbidden to combine this antibiotic with the use of Heparin.
Related problems
It is known that the antibiotic is well tolerated by many patients, but the instructions for use indicate possible side effects, which are also described in patient reviews. In case of unpleasant phenomena, it is necessary to stop taking the pills and immediately seek advice. The side effects that occur most often and are described in the annotation include:
- signs of dyspepsia;
- nausea;
- pain behind the sternum;
- arrhythmia;
- dizziness;
- weakness;
- headache;
- skin rash itching, manifestations of urticaria;
- conjunctivitis.
In connection with an individual increased reaction to the components of the drug, Quincke's edema may occur. Also, vaginal candidiasis may appear on the part of the reproductive system, however, such a phenomenon is recorded very rarely.
Contraindications
Not all patients can take Azitrox 500. The instructions list both absolute and relative contraindications. It is strictly forbidden to prescribe the drug for severe renal or liver failure, intolerance to sucrose and fructose, as well as for increased individual sensitivity to any component of the drug.
There are also temporary restrictions on the use of this antibiotic. Such symptoms are considered relative indications and only the doctor must decide on the appointment for the following pathologies:
- diabetes;
- arrhythmia;
- pregnancy and lactation;
- myasthenia gravis;
- heart failure;
- moderate malfunctioning of the liver.
These diseases are the reason for special monitoring of the patient during treatment.
Possible replacement
Azitrox 500, has analogues, but they must be considered if the patient is worried about side effects or the drug is not suitable. In the presence of concomitant diseases, the following drugs may be a possible replacement for the medication:
- "Zitrocin" is a medication from the macrolide group that has an antimicrobial effect. Available in the form of tablets and a solution for intravenous administration.
- Azivoc is also supplied in the form of gelatin capsules, the main component of which is azithromycin. Assign to patients over 12 years old, one per day. The course of treatment lasts from two to five days.
- "Azitral" is a capsule having a different concentration of azithromycin. The treatment is usually complex, the dosage is adjusted depending on the nature of the disease.
- "Sumamed" - a drug that is presented in the form of tablets, capsules and suspensions. The dosage and recommended form of release depends on the severity of the disease, the type of pathology and age of the patient.
Antibiotic cost
A wide range of applications has Azitrox 500. The price, in addition to instructions for use and possible effectiveness, is also of interest to almost every patient. The average cost of the drug in question is 250 - 300 rubles. and depends on the place of sale. Buy "Azitrox 500", like any antibiotic can be in a pharmacy upon presentation of a valid prescription from a doctor.
Drug feedback
Azitrox 500, reviews are positive. The antibiotic is good for pathologies of ENT organs and respiratory tract. Patients like that the course of administration does not take more than five days, and it is necessary to take only one capsule per day. The medicine helps quickly, and side effects rarely occur. According to experts and patients, the drug is very effective. Sold in almost all pharmacies, has a relatively low cost.
Among the advantages, many distinguish its rapid action, effectiveness in many bacterial pathologies and a single daily intake. If we consider the shortcomings in the first place is the resulting diarrhea, a rash on the skin and the body’s addiction to azithromycin.
Conclusion
The medicine is a broad-spectrum antibiotic. It is released from pharmacies only by prescription, quickly helps to remove the symptoms of bacterial infection, to get rid of unpleasant consequences. Side effects rarely occur, so doctors often prescribe this drug. An analogue is selected only in case of individual incompatibility or the detection of unpleasant symptoms during treatment.
Keep the drug in a cool place, inaccessible to children's hands. It is not necessary to place the capsules in the refrigerator, but it is important to protect them from direct sunlight. Before taking, you should pay attention to the expiration date and do not use capsules after it has expired.
If it is necessary to use "Azitroks" in the treatment of children, then only suspension is used. Capsules are allowed to be offered by a teenager from 12 years old. Analogs, for the most part, are also intended for patients older than 10-12 years. in any case, it is necessary to consult a doctor before use.