In today's world, a person is surrounded by a huge number of microorganisms that can cause him infectious diseases of various organs. The blow may include: the stomach, intestines, kidneys, bladder, genitals, and many others. Each infection, if not cured in time, can lead to certain complications. It is worth noting that sometimes the infectious process is almost asymptomatic, and the diagnosis is made only by the results of laboratory tests. Despite the absence of symptoms or their mild manifestation, each infection must be treated. To do this, you should consult an infectious disease doctor who, if he considers it necessary, will prescribe the necessary treatment. Often in such situations, the doctor prescribes treatment with antiprotozoal drugs. One of them is the drug Gyro.
Gayro is an antiprotozoal (antiparasitic) drug manufactured by the Indian pharmaceutical company Panacea biotec Ltd. Active ingredient "Gayro" is ornidazole.
Description
Instructions for use "Gayro" describes the drug as follows: oblong tablets, coated with a green shell. On one side there is a risk for the convenience of dividing if you need to take a lower dosage. The tablet form is biconvex.
Release form
The drug is available in several versions. One blister can have 3 tablets, or maybe 10. In the first case, 1, 5, 10 blisters will be contained in a cardboard box, in the second case - 1 or 2 blisters. That is, these release forms differ only in the number of tablets in one package.
Composition and mechanism of action
Instructions for use "Gayro" claims that one tablet of the drug includes 500 mg of ornidazole. The remaining components are excipients.
The mechanism of action of the drug is that ornidazole in its chemical formula is a derivative of 5-nitroimidazole. In these substances, when interacting with anaerobic microorganisms, the 5-nitro group is reduced. It disrupts the synthesis of nucleic acids, destroying the DNA of microorganisms, thereby causing their death.
Ornidazole has bactericidal and bacteriostatic effects. Thanks to the first function, it kills microorganisms, and thanks to the second, it stops their reproduction in the human body. Violation of the respiratory processes in representatives of pathogenic microflora is another function of Gyro. The instruction for the drug contains information about this.
Indications for use
Gayro has a very diverse spectrum of action. It is active against many anaerobic microorganisms indicated in the instructions for use. Gyro (500 mg) has a large list of indications for use:
- Trichomoniasis
- Amoebiasis of all possible forms (intestinal and / or extraintestinal amoebiasis, amoebic dysentery. This also includes the asymptomatic form of amoebiasis).
- Giardiasis
- Gynecological infections, as well as infections of the gastrointestinal tract caused by anaerobic microorganisms, such as eubacteria, peptococci, bacterioids, clostridia, peptostreptococci and other anaerobic microorganisms that are sensitive to ornidazole.
- According to the instructions for Gairo, the drug is also used as part of complex therapy (together with antibiotics and bismuth preparations) for the treatment of peptic ulcer of the duodenum or stomach in order to destroy Helicobacter pylori.
- As a prophylaxis, the drug ornidazole is prescribed before surgery on the gastrointestinal tract or gynecological operations. This is done in order to prevent the occurrence of possible infectious complications after surgery.
Contraindications
Instructions for use "Gayro" indicates the following contraindications:
- Allergy to any of the components of the drug.
- Low white blood cell count (leukopenia).
- Diseases of the central nervous system (epilepsy and the like).
- Children's age from 0 to 3 years.
- 1st trimester of pregnancy and the period of breastfeeding.
- Galactose intolerance.
- Lack of an enzyme such as lactase in the body.
- Impaired absorption of glucose and galactose by the intestinal walls.
Use with caution
The Gyro pill instruction notes that when taking this drug, special care should be taken in patients with renal and / or liver failure. The same applies to the elderly, patients with suppressed bone marrow function, as well as with a violation of the central nervous system.
Use during pregnancy and breastfeeding
Instructions for the use of Gayro tablets indicate that the drug is forbidden to be taken by pregnant women whose gestation period has not reached 13 weeks. Treatment with this drug is also prohibited for those women who breastfeed.
Pregnant in the 2nd and 3rd trimesters, this drug should be taken with caution.
Adverse reactions
Like any other drug, Gyro has a number of side effects that can affect some body systems:
- Central nervous system: headache, dizziness, impaired coordination of movements, tremors, seizures, sleep disturbances, increased irritability and irritability, as well as short-term loss of consciousness are possible.
- Digestive system: epigastric pain, stool disorders, decreased or lack of appetite, the appearance of nausea and / or vomiting.
- Hematopoietic system: a decrease in the level of white blood cells in the blood.
- Musculoskeletal system: the occurrence of pain in the joints.
- It is also possible the appearance of allergies in the form of itching and a rash on the skin, urticaria.
Dosage and administration
Ornidazole preparations are not recommended for use on an empty stomach, therefore it is necessary to take Gyro immediately after a meal, with a glass of drinking water. The use of the drug after meals will help reduce the risk of unwanted adverse reactions from the digestive system.
Dosage and duration of the course depend on the diagnosis and the results of laboratory tests. In addition, the treatment regimen depends on the patient’s body weight. A single dosage for adults according to the instructions for Gyro is 500-2000 mg.
Dosage for children whose weight is less than 35 kg is calculated individually according to the following scheme: 20-40 mg / kg. The frequency of admission and the duration of the course is set by the attending physician, as indicated by the instructions for use of Gyro.
Overdose
The drug should be taken strictly according to the instructions, unless the doctor has prescribed otherwise. Otherwise, an overdose is possible, which manifests itself in the form of nausea and vomiting, dizziness and headaches. With a strong overdose of the drug, seizures, sensory disturbances of touch, depressive mood may occur.
If there are signs of an overdose, you should immediately seek help from a medical organization, where symptomatic treatment will be carried out.
Interaction with other drugs
- Gayro enhances the effect of coumarin anticoagulants (Warfarin and the like).
- The drug prolongs the action of the muscle relaxant vecuronium bromide.
- The active ingredient of the drug, ornidazole, is compatible with ethyl alcohol, so there is no need to give up alcohol during the treatment with Gayro.
special instructions
With a slowdown in metabolism, the concentration of ornidazole in blood plasma increases, so the administration of the drug to patients with liver failure should be carried out very carefully.
Patients with renal insufficiency need to be prescribed dosages half the standard, as in such people the process of eliminating the drug is slowed down. If a patient with renal insufficiency is prescribed a standard dose of the drug, this can lead to an overdose.
If any neurological impairment occurs, the use of Gyro should be stopped urgently.
It is very important to monitor the dynamics of the treatment process using medical tests.
If a long course of treatment is required (longer than 10 days), it makes sense to take a blood test for white blood cells and liver tests. In case of a decrease in the level of leukocytes in the blood, the possibility of treatment with this drug depends on the diagnosis and is decided jointly with the attending physician.
Patients of both sexes who are undergoing trichomoniasis treatment should refrain from sexual activity. In this case, the simultaneous treatment of both partners is a prerequisite for successful therapy. After completing the Gyro course in women, it is imperative that appropriate tests be performed for three cycles before and after menstruation.
Patients who have undergone treatment of giardiasis with the help of Gyro, but still observing the symptoms of the disease, must pass 3 stool tests with an interval of 7 days. The fact is that there are cases when the symptoms of lactose intolerance, which cause Giardia, persist for a long time, although the person was successfully treated.
Storage and shelf life
Gayro tablets must be stored in a dry place, the air temperature in which should not exceed 30 ° C, away from sunlight.
Like any other drug, Gyro should be kept out of the reach of children.
Shelf life is 3 years from the date of production. An expired drug should never be used.
Holiday Terms
"Gayro" is a prescription drug, therefore, for its purchase in a pharmacy organization, it is necessary to have a prescription written by a doctor. So indicated in the instructions for use "Gayro".
Analogs
Gayro is not the only drug on the pharmaceutical market containing ornidazole. For example, the Russian drug Ornidazol-Vero, which is manufactured by Vero-Farm OJSC, can become an excellent substitute for Guyro. Another Russian analogue of Gayro is Ornidazole from the Vertex pharmaceutical company.
There is also a drug called Dazolik. He, like Gyro, is a drug made in India, but another pharmaceutical company is Sun Pharmaceutical Industries Ltd.
Gairo has many analogues, they all contain 500 mg of ornidazole, which means they have the same spectrum of action, a list of indications, contraindications, and so on.
Reviews
This drug is prescribed quite often, because it has a diverse spectrum of action, indicated in the instructions for use of "Gyro". Reviews of people who have been treated for certain infections with the drug "Gyro" are mostly positive. Many note a rapid improvement in well-being and normalization of the results of laboratory tests during treatment with this drug. Others did not have or were very mild side effects. Others noted that the combination with alcohol is a positive point in the treatment with Gyro.
A large list of unwanted adverse reactions contains the instruction "Gyro". Reviews that are negative are mainly associated with the manifestation of these effects in patients. For example, someone had to completely stop taking the medicine because of the occurrence of severe adverse reactions.
Gayro is an inexpensive and effective antiprotozoal drug with a wide spectrum of action. Treatment with this drug must be carried out after an accurate diagnosis is established and only as directed by the doctor, observing the dosage and frequency of administration.