Modern pharmaceuticals can provide a medicine to reduce the symptoms of any pathology. Quite often, memory problems, headaches appear due to impaired blood circulation in the brain. If you take special medications, then it is quite possible to significantly alleviate the patient's condition and improve his quality of life. “Combitropil” is a combined medicine that has antihypoxic, nootropic and vasodilating properties. The drug is easily absorbed by the body, helps to normalize blood flow and metabolic processes in the brain. Reviews about the “Combitropil” of doctors and patients are only positive, and all thanks to a properly selected composition.
Composition and form of release
The drug “Combitropil” is available in the form of gelatin-coated capsules. In pharmacies, you can buy medicine in cardboard packages of 30 or 60 pieces, as well as in jars of 20-60 capsules.
Each gelatin capsule contains two main components: piracetam 400 mg and cinnarizine 25 mg.
Also in the composition there are additional components: lactose, magnesium stearate, talc and MCC.
The gelatin shell is made of titanium dioxide, methyl parahydroxybenzoate, acetic acid and gelatin are present.
How does the drug work?
Both of the main components in the “ Combitropil” preparation, reviews of doctors confirm this fact, are ideally selected, because they mutually potentiate their own antihypoxic effect and contribute to vasodilation. Also, the drug helps to increase blood flow in the brain. The toxicity of this composition is the smallest when compared with drugs with one of the active ingredients. Piracetam is a nootropic substance that has a beneficial effect on metabolic processes in the brain:
- accelerates the production of RNA and phospholipids;
- normalizes glycolytic processes;
- helps utilize glucose;
- increases the concentration of ATP in the brain tissue.
Helps integrative brain activity, memory consolidation, facilitates learning processes.
It changes the rate of excitation in the brain, activates microcirculation, but it does not dilate blood vessels, reduces the aggregation of active platelets.
Includes protective function in case of brain damage caused by hypoxia, intoxication or electroshock. It also enhances α- and β-activity, significantly reduces δ-activity in the encephalogram, and reduces vestibular nystagmus.
It activates the transmission of impulses between neurons and synaptic conduction in the brain structures, increases intellectual performance, improves blood flow in the brain.
Piracetam as a part of the drug " Combitropil", the doctors' reviews confirm this fact, have a gradual effect on the body, has a minimal level of sedative and psychostimulating effect. The therapeutic effect occurs after 1-6 hours.
Cinnarizine is a calcium channel blocker, it helps to reduce the intake of calcium ions in the cells of the body, reduces the level of calcium in the plasma depot, reduces the smooth muscle tone of large arteries and their response to nutrients responsible for vasoconstriction.
It has a vasodilating effect, especially for vessels in the brain, thereby enhancing the antihypoxic effect of piracetam, but does not affect blood pressure.
It has a moderate antihistamine activity, reduces the excitability of the vestibular apparatus and the sympathetic department of the peripheral nervous system.
In patients who have a violation of peripheral circulation, blood flow in organs and tissues is significantly improved, post-ischemic vasodilation improves.
The elasticity of the walls of red blood cells improves, their ability to deform, and blood viscosity decreases.
Indications for use
According to doctors, “Combitropil ” is effective for patients who have:
- impaired blood circulation in the brain, this applies to cerebral arteriosclerosis, ischemic stroke, during recovery from hemorrhagic stroke and traumatic brain injury;
- encephalopathy of various origins;
- coma and subcomatose state after brain injury and intoxication;
- disturbances in the work of the nervous system, which are accompanied by a decrease in intellectual functions;
- labyrinthopathy of various genesis, in which dizziness, tinnitus, nausea and vomiting are observed;
- Depression
- psycho-organic syndrome, in which signs of adynamia and asthenia predominate;
- asthenia of a psychogenic nature;
- memory problems, impaired thinking and decreased concentration of attention;
- lag in intellectual development in children.
When is it not recommended to take the drug?
Before you start taking the drug " Combitropil", in the reviews and instructions for use, this is noted, you need to know about contraindications:
- severe renal and hepatic insufficiency;
- Parkinson's disease;
- the period of bearing the baby;
- lactation;
- children under 5 years old;
- increased susceptibility to the components of the drug.
How to take the drug?
Capsules are taken orally:
- adults are recommended 1-2 capsules three times a day, you need to take from 1 to 3 months, depending on the severity of the disease;
- babies from 5 years old take 1-2 tablets once or twice a day for 1-3 months.
Therapy is recommended 2-3 times a year.
If the patient has chronic renal failure and can not do without the drug, then the doctor should select the dose, it usually decreases and the interval between doses increases.
“Combitropil” for children
"Combitropil" is recommended for children from only five years old. Reception is allowed from one year, but this is only with the permission of the doctor, under his close attention and only in the rarest cases.
The medicine helps children and adolescents normalize sleep, remove all nightmares from dreams, stop awakenings in the middle of the night, reduce fatigue, irritability, vulnerability and lability of mood, and increase mental performance.
In addition, the medicine helps to reduce the frequency of headaches, improves adaptation in preschool and school institutions, maintains a normal level of blood pressure, preventing its jumps. In general, the drug normalizes the neuropsychic status of the child, especially one that suffers from various disorders in the emotional and volitional sphere.
Today, doctors recommend parents to use the drug for insomnia in children, constant irritability, tearfulness, often changing moods, tantrums, poor concentration. A neurologist appoints him after a thorough examination of the child.
After completing the course of treatment, the child is much calmer, he studies better, becomes attentive and focused.
The drug is recommended to improve mental performance and proper development of the child.
Undesirable manifestations
If you increase the dose and take more tablets, then side effects may appear:
- from the central nervous system: insomnia, irritability, headaches, trembling in the limbs;
- from the digestive system: dry mouth, dyspepsia, epigastric pain syndrome;
- allergic reactions in the form of redness, itching and rash.
special instructions
While taking the drug “ Combitropil”, reviews of doctors emphasize this, it is necessary to control the liver and kidneys.
During therapy, alcohol-containing drinks should not be taken.
In view of the fact that cinnarizine is present in the preparation, it is worth remembering that in athletes during the doping control it can give a positive reaction.
The drug " Combitropil", instructions and reviews of doctors warn about this, it should be taken with caution in patients with high intraocular pressure.
During therapy, it is important to remember that when driving a vehicle you need to be as careful as possible, as well as engaging in activities that require an increased concentration of attention and speed of psychomotor reactions.
Interaction with other drugs
It is worth remembering that the combined use of Combitropil with drugs that inhibit the nervous system enhances their effect. It also acts on nootropic and antihypertensive drugs.
It helps to increase the tolerance of antipsychotics and tricyclic antidepressants, but vasodilating drugs, on the contrary, enhance the effect of "Combitropil".
Analogs and price
There are many analogues of “Combitropil”. He is considered the generic “Fezama”. Also, the list of drugs that can easily replace it, if for some reason the reception is prohibited, includes such means:
- Omaron
- Zinnotropil;
- "Fescetam";
- "Piracezin";
- Noocam.
In addition, there are drugs that contain one of the main components of Combitropil - cinnarizine: Stugeron.
And piracetam is present in such medicines:
- Lucetam
- Piracetam
- Nootropil;
- Memotropil.
As for the cost of the drug, it ranges from 90-110 rubles per pack of 30 capsules.
"Combitropil": reviews of patients and doctors
It is impossible to say that all reviews about the drug are only positive. There are also patients who are not very happy with its action, and all this is not because the drug is not always effective, but because it causes some undesirable manifestations. But each person has his own characteristics of the body and the course of the disease is different, there are concomitant ailments, so you can not focus on individual patients.
The doctors themselves say that the drug is effective and helps to easily cope with very serious diseases, the main thing is to fully comply with the dosage and all the recommendations of the doctor.
Instructions for the use of "Combitropil" and analogues, patient reviews confirm that the tool is very effective in combating many serious problems and gently relieves bad mood, insomnia and other manifestations of ailments.